Blast Analysis : gnl|CDD|119392

Analysis  rpsblast_cdd Start  107
End  525 Strand  +
Length  419 Note  Gaps:19
Hit Coverage  98.30 Hit Length  352
Hit Pident  26.88 E Val  3e-16
Hit Description  cd06174 MFS The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters symporters and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions sugar phosphates drugs neurotransmitters nucleosides amino acids and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate while symporters and antiporters transport two substrates in the same or in opposite directions respectively across membranes. MFS proteins are typically 400 to 600 amino acids in length and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members GlpT (glycerol-3-phosphate transporter) LacY (lactose permease) and EmrD (multidrug transporter) MFS proteins are thought to function through a single substrate binding site alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4 which is impaired in type II diabetes and glucose-6-phosphate transporter (G6PT) which causes glycogen storage disease when mutated.. Hit Pcons  16.18
Name  Qrob_P0029990.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0029990.2 Quercus robur 99.0 egn (M=2) KOG0252//KOG0253//KOG0254//KOG0255//KOG0569//KOG2533 - Inorganic phosphate transporter [Inorganic ion transport and metabolism]. // Synaptic vesicle transporter SV2 (major facilitator superfamily) [General function prediction only]. // Predicted transporter (major facilitator superfamily) [General function prediction only]. // Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) [General function prediction only]. // Permease of the major facilitator superfamily [Carbohydrate transport and metabolism]. // Permease of the major facilitator superfamily [Carbohydrate transport and metabolism].     validated