Blast Analysis : gnl|CDD|190619

Analysis  rpsblast_cdd Start  316
End  371 Strand  +
Length  56 Note  none
Hit Coverage  12.87 Hit Length  435
Hit Pident  51.79 E Val  4e-18
Hit Description  pfam03378 CAS_CSE1 CAS/CSE protein C-terminus. Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1 it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase) and has been shown to be associated with the microtubule network and the mitotic spindle as is the protein MEK which is thought to regulate the intracellular localisation (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors) it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins. Hit Pcons  23.21
Name  Qrob_P0009880.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0009880.2 Quercus robur 28.0 egn (M=1) KOG0044//KOG1992//KOG4223 - Ca2+ sensor (EF-Hand superfamily) [Signal transduction mechanisms]. // Nuclear export receptor CSE1/CAS (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Reticulocalbin calumenin DNA supercoiling factor and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport].     validated