Protein : Qrob_P0740770.2 Q. robur
Protein Identifier  ? Qrob_P0740770.2 Organism . Name  Quercus robur
Score  90.0 Score Type  egn
Protein Description  (M=2) K12385 - Niemann-Pick C1 protein Gene Prediction Quality  validated
Protein length 

Sequence

Length: 1131  
Kegg Orthology  K12385
Paste the following link
Lists
This Protein isn't in any lists. Upload a list.

Sequence Feature Displayer

Protein Sequence Displayer

J Browse Displayer

0 Synonyms

4 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0008158 hedgehog receptor activity Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.
GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

32 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100242789 29 1130 + 1102 Gaps:57 83.19 1309 84.66 0.0 niemann-Pick C1 protein-like
blastp_kegg lcl|pop:POPTR_0005s27320g 2 1130 + 1129 Gaps:59 85.76 1299 81.96 0.0 POPTRDRAFT_818865 hypothetical protein
blastp_kegg lcl|pxb:103955523 2 1130 + 1129 Gaps:61 86.27 1289 80.40 0.0 Niemann-Pick C1 protein-like
blastp_kegg lcl|tcc:TCM_034394 4 1130 + 1127 Gaps:70 85.64 1288 82.05 0.0 Hedgehog receptor putative isoform 1
blastp_kegg lcl|pmum:103336673 5 1130 + 1126 Gaps:62 86.02 1288 82.04 0.0 Niemann-Pick C1 protein-like
blastp_kegg lcl|rcu:RCOM_1601160 40 1130 + 1091 Gaps:64 86.72 1235 84.03 0.0 hedgehog receptor putative
blastp_kegg lcl|cic:CICLE_v10000039mg 4 1130 + 1127 Gaps:59 86.11 1296 80.38 0.0 hypothetical protein
blastp_kegg lcl|cit:102618032 4 1130 + 1127 Gaps:59 86.11 1296 80.38 0.0 niemann-Pick C1 protein-like
blastp_kegg lcl|pper:PRUPE_ppa000374mg 40 1130 + 1091 Gaps:57 87.57 1231 82.65 0.0 hypothetical protein
blastp_kegg lcl|gmx:100784611 2 1130 + 1129 Gaps:62 86.52 1291 78.33 0.0 niemann-Pick C1 protein-like
blastp_pdb 3gkj_A 38 243 + 206 Gaps:19 94.40 232 32.88 2e-25 mol:protein length:232 Niemann-Pick C1 protein
blastp_pdb 3gki_A 38 243 + 206 Gaps:19 94.40 232 32.88 2e-25 mol:protein length:232 Niemann-Pick C1 protein
blastp_pdb 3gkh_A 38 243 + 206 Gaps:19 94.40 232 32.88 2e-25 mol:protein length:232 Niemann-Pick C1 protein
blastp_pdb 3qnt_A 33 246 + 214 Gaps:25 88.68 265 32.77 1e-22 mol:protein length:265 Niemann-Pick C1-like protein 1
blastp_uniprot_sprot sp|P56941|NPC1_PIG 38 1130 + 1093 Gaps:161 84.73 1277 35.58 0.0 Niemann-Pick C1 protein OS Sus scrofa GN NPC1 PE 2 SV 1
blastp_uniprot_sprot sp|O15118|NPC1_HUMAN 38 1130 + 1093 Gaps:164 84.74 1278 35.18 4e-178 Niemann-Pick C1 protein OS Homo sapiens GN NPC1 PE 1 SV 2
blastp_uniprot_sprot sp|O35604|NPC1_MOUSE 38 1130 + 1093 Gaps:189 84.73 1277 34.94 4e-177 Niemann-Pick C1 protein OS Mus musculus GN Npc1 PE 1 SV 2
blastp_uniprot_sprot sp|Q6T3U3|NPCL1_RAT 32 1127 + 1096 Gaps:206 82.19 1331 34.64 1e-152 Niemann-Pick C1-like protein 1 OS Rattus norvegicus GN Npc1l1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9UHC9|NPCL1_HUMAN 33 1129 + 1097 Gaps:213 82.41 1359 34.02 2e-146 Niemann-Pick C1-like protein 1 OS Homo sapiens GN NPC1L1 PE 1 SV 2
blastp_uniprot_sprot sp|Q6T3U4|NPCL1_MOUSE 33 1127 + 1095 Gaps:192 82.00 1333 33.39 1e-136 Niemann-Pick C1-like protein 1 OS Mus musculus GN Npc1l1 PE 2 SV 1
blastp_uniprot_sprot sp|Q12200|NPC1_YEAST 38 1114 + 1077 Gaps:181 83.08 1170 32.20 4e-121 Niemann-Pick type C-related protein 1 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN NCR1 PE 1 SV 1
blastp_uniprot_sprot sp|Q19127|NPC1_CAEEL 32 1129 + 1098 Gaps:187 81.20 1383 25.82 1e-85 Niemann-Pick C1 protein homolog 1 OS Caenorhabditis elegans GN ncr-1 PE 1 SV 2
blastp_uniprot_sprot sp|P34389|NPC2_CAEEL 81 1117 + 1037 Gaps:203 78.18 1274 27.11 3e-74 Niemann-Pick C1 protein homolog 2 OS Caenorhabditis elegans GN ncr-2 PE 3 SV 2
blastp_uniprot_sprot sp|Q61115|PTC1_MOUSE 567 795 + 229 Gaps:13 15.76 1434 35.84 1e-29 Protein patched homolog 1 OS Mus musculus GN Ptch1 PE 1 SV 1
rpsblast_cdd gnl|CDD|162106 38 1130 + 1093 Gaps:130 87.96 1204 55.34 0.0 TIGR00917 2A060601 Niemann-Pick C type protein family. The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis.
rpsblast_cdd gnl|CDD|192997 647 798 + 152 none 99.35 153 55.92 1e-54 pfam12349 Sterol-sensing Sterol-sensing domain of SREBP cleavage-activation. Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1 which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
rpsblast_cdd gnl|CDD|111366 544 916 + 373 Gaps:27 43.95 801 25.28 6e-45 pfam02460 Patched Patched family. The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
rpsblast_cdd gnl|CDD|162107 575 795 + 221 Gaps:8 18.60 1145 38.50 8e-33 TIGR00918 2A060602 The Eukaryotic (Putative) Sterol Transporter (EST) Family.
rpsblast_cdd gnl|CDD|31236 577 780 + 204 Gaps:34 49.66 727 21.61 1e-07 COG1033 COG1033 Predicted exporters of the RND superfamily [General function prediction only].
rpsblast_kog gnl|CDD|37144 37 1130 + 1094 Gaps:149 85.68 1201 44.22 0.0 KOG1933 KOG1933 KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) [Lipid transport and metabolism].

30 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 277 296 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 580 789 210 G3DSA:1.20.1640.10 none none none
Phobius 1 16 16 SIGNAL_PEPTIDE none Signal peptide region none
PANTHER 38 262 225 PTHR10796 none none none
SUPERFAMILY 574 780 207 SSF82866 none none none
Phobius 651 675 25 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 707 725 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
ProSiteProfiles 617 780 164 PS50156 none Sterol-sensing domain (SSD) profile. IPR000731
Phobius 850 873 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 749 753 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 12 16 5 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
PANTHER 324 1130 807 PTHR10796 none none none
Pfam 435 916 482 PF02460 none Patched family IPR003392
Phobius 618 639 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 754 780 27 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 370 389 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 781 849 69 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
TIGRFAM 38 998 961 TIGR00917 none 2A060601: Niemann-Pick C type protein family IPR004765
PANTHER 324 1130 807 PTHR10796:SF35 none none none
Phobius 3 11 9 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
Phobius 640 650 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 874 1130 257 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 681 706 26 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 297 369 73 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 38 262 225 PTHR10796:SF35 none none none
Phobius 390 617 228 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 17 276 260 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 726 748 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 676 680 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 1 2 2 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none

8 Localization

Analysis Start End Length
TMHMM 275 297 22
TMHMM 681 703 22
TMHMM 615 637 22
TMHMM 758 780 22
TMHMM 726 748 22
TMHMM 644 666 22
TMHMM 369 391 22
TMHMM 849 871 22

15 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL2_d13Cf Qrob_Chr02 2 s_1AQA4Z_1644 s_1AK5QX_947 53.67 14,01 79,68 lod 5.6594 0.03
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran2_2002_QTL9_peak_Bud_burst_A4 Qrob_Chr02 2 s_1BFNDA_375 s_1A3VA1_2139 32,5 17 62 lod 3,1 4,2
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 24,87 24,63 26,18 lod 3.8 7
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran1_2003_QTL1_peak_Bud_burst_3P Qrob_Chr02 2 s_1AR8KI_1183 s_1B0QB1_473 22 6 41 lod 4,2 11,5
Bourran1_2004_QTL3_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 46 lod 2,9 6,4
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5
Champenoux_2015_nEpis_A4 Qrob_Chr02 2 s_1BAGIZ_823 s_1BN4CB_644 23,06 23,06 23,06 lod 4.9 11
Champenoux_2015_nP_A4 Qrob_Chr02 2 s_1BN4CB_644 v_508_128 23,76 23,06 24,51 lod 2.8 6.2
Champenoux_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 25,35 24,63 26,18 lod 4.0 8.7
Champenoux_2015_nSecLBD_A4 Qrob_Chr02 2 s_1AN4ZM_1665 v_8587_238 18,52 18,89 18,27 lod 3.2 7.4

0 Targeting