Protein : Qrob_P0736170.2 Q. robur
Protein Identifier  ? Qrob_P0736170.2 Organism . Name  Quercus robur
Score  85.2 Score Type  egn
Protein Description  (M=1) K11126 - telomerase reverse transcriptase [EC:2.7.7.49] Code Enzyme  EC:2.7.7.49
Gene Prediction Quality  validated Protein length 

Sequence

Length: 880  
Kegg Orthology  K11126
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003964 RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
GO:0003721 telomeric template RNA reverse transcriptase activity Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pxb:103945875 71 879 + 809 Gaps:58 66.26 1236 59.71 0.0 telomerase reverse transcriptase
blastp_kegg lcl|mdm:103438500 14 879 + 866 Gaps:73 71.88 1209 57.54 0.0 telomerase reverse transcriptase
blastp_kegg lcl|pper:PRUPE_ppa015223mg 180 879 + 700 Gaps:56 84.94 883 61.47 0.0 hypothetical protein
blastp_kegg lcl|pmum:103330484 145 879 + 735 Gaps:63 61.68 1284 58.59 0.0 telomerase reverse transcriptase
blastp_kegg lcl|cic:CICLE_v10030541mg 14 879 + 866 Gaps:66 74.27 1205 55.20 0.0 hypothetical protein
blastp_kegg lcl|cit:102625932 14 879 + 866 Gaps:67 72.08 1275 54.41 0.0 telomerase reverse transcriptase-like
blastp_kegg lcl|pvu:PHAVU_005G021500g 155 879 + 725 Gaps:61 62.16 1242 54.27 0.0 hypothetical protein
blastp_kegg lcl|gmx:100790649 106 879 + 774 Gaps:77 64.68 1257 54.24 0.0 telomerase reverse transcriptase-like
blastp_kegg lcl|pop:POPTR_0003s01700g 175 879 + 705 Gaps:66 63.91 1172 57.94 0.0 hypothetical protein
blastp_kegg lcl|gmx:100776816 167 879 + 713 Gaps:58 67.96 1108 54.98 0.0 telomerase reverse transcriptase-like
blastp_pdb 2r4g_A 190 334 + 145 Gaps:28 46.07 267 31.71 5e-09 mol:protein length:267 Telomerase reverse transcriptase
blastp_uniprot_sprot sp|Q9SPU7|TERT_ARATH 123 879 + 757 Gaps:114 65.81 1123 43.44 1e-173 Telomerase reverse transcriptase OS Arabidopsis thaliana GN TERT PE 1 SV 1
blastp_uniprot_sprot sp|Q8LKW0|TERT_ORYSJ 163 879 + 717 Gaps:137 55.44 1259 40.83 2e-136 Telomerase reverse transcriptase OS Oryza sativa subsp. japonica GN TERT PE 2 SV 2
blastp_uniprot_sprot sp|O14746|TERT_HUMAN 190 814 + 625 Gaps:93 49.65 1132 32.74 2e-57 Telomerase reverse transcriptase OS Homo sapiens GN TERT PE 1 SV 1
blastp_uniprot_sprot sp|Q6A548|TERT_CANFA 190 827 + 638 Gaps:95 51.56 1123 32.30 1e-56 Telomerase reverse transcriptase OS Canis familiaris GN TERT PE 2 SV 1
blastp_uniprot_sprot sp|Q27ID4|TERT_BOVIN 190 827 + 638 Gaps:109 51.29 1125 31.54 2e-56 Telomerase reverse transcriptase OS Bos taurus GN TERT PE 3 SV 2
blastp_uniprot_sprot sp|Q673L6|TERT_RAT 190 827 + 638 Gaps:96 51.56 1125 33.79 2e-56 Telomerase reverse transcriptase OS Rattus norvegicus GN Tert PE 2 SV 1
blastp_uniprot_sprot sp|O70372|TERT_MOUSE 190 827 + 638 Gaps:92 51.69 1122 32.76 3e-54 Telomerase reverse transcriptase OS Mus musculus GN Tert PE 1 SV 1
blastp_uniprot_sprot sp|O13339|TERT_SCHPO 180 699 + 520 Gaps:94 45.75 988 29.20 1e-34 Telomerase reverse transcriptase OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN trt1 PE 1 SV 1
blastp_uniprot_sprot sp|O77448|TERT_TETTH 190 812 + 623 Gaps:131 52.82 1117 28.14 2e-33 Telomerase reverse transcriptase OS Tetrahymena thermophila GN TERT PE 1 SV 1
blastp_uniprot_sprot sp|O76332|TERT_OXYTR 188 805 + 618 Gaps:100 50.71 1132 25.61 1e-31 Telomerase reverse transcriptase OS Oxytricha trifallax GN TERT PE 3 SV 1
rpsblast_cdd gnl|CDD|192913 189 346 + 158 Gaps:22 100.00 136 41.18 2e-34 pfam12009 Telomerase_RBD Telomerase ribonucleoprotein complex - RNA binding domain. Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.
rpsblast_cdd gnl|CDD|198043 190 346 + 157 Gaps:21 100.00 136 36.03 8e-30 smart00975 Telomerase_RBD Telomerase ribonucleoprotein complex - RNA binding domain. Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.
rpsblast_cdd gnl|CDD|73155 586 729 + 144 Gaps:37 91.60 119 43.12 2e-20 cd01648 TERT TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase reverse transcriptase (TERT). The reverse transcriptase (RT) domain is located in the C-terminal region of the TERT polypeptide. Single amino acid substitutions in this region lead to telomere shortening and senescence. Telomerase is an enzyme that in certain cells maintains the physical ends of chromosomes (telomeres) during replication. In somatic cells replication of the lagging strand requires the continual presence of an RNA primer approximately 200 nucleotides upstream which is complementary to the template strand. Since there is a region of DNA less than 200 base pairs from the end of the chromosome where this is not possible the chromosome is continually shortened. However a surplus of repetitive DNA at the chromosome ends protects against the erosion of gene-encoding DNA. Telomerase is not normally expressed in somatic cells. It has been suggested that exogenous TERT may extend the lifespan of or even immortalize the cell. However recent studies have shown that telomerase activity can be induced by a number of oncogenes. Conversely the oncogene c-myc can be activated in human TERT immortalized cells. Sequence comparisons place the telomerase proteins in the RT family but reveal hallmarks that distinguish them from retroviral and retrotransposon relatives..
rpsblast_kog gnl|CDD|36223 127 846 + 720 Gaps:104 71.62 888 29.56 2e-96 KOG1005 KOG1005 KOG1005 Telomerase catalytic subunit/reverse transcriptase TERT [Replication recombination and repair Chromatin structure and dynamics].

17 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 471 511 41 SSF56672 none none none
SUPERFAMILY 571 724 154 SSF56672 none none none
PANTHER 655 809 155 PTHR12066 none none none
PANTHER 284 631 348 PTHR12066:SF0 none none none
PANTHER 655 809 155 PTHR12066:SF0 none none none
Pfam 479 695 217 PF00078 none Reverse transcriptase (RNA-dependent DNA polymerase) IPR000477
Phobius 316 879 564 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 296 315 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 295 295 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
ProSiteProfiles 355 728 374 PS50878 none Reverse transcriptase (RT) catalytic domain profile. IPR000477
SMART 189 346 158 SM00975 none Telomerase ribonucleoprotein complex - RNA binding domain IPR021891
PANTHER 189 262 74 PTHR12066:SF0 none none none
Pfam 189 345 157 PF12009 none Telomerase ribonucleoprotein complex - RNA binding domain IPR021891
PANTHER 284 631 348 PTHR12066 none none none
PANTHER 189 262 74 PTHR12066 none none none
PRINTS 589 605 17 PR01365 none Telomere reverse transcriptase signature IPR003545
PRINTS 313 327 15 PR01365 none Telomere reverse transcriptase signature IPR003545

0 Localization

1 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_rEpiBC_3P Qrob_Chr05 5 s_2GDU0O_517 s_1BT8O3_239 25,81 0 55,45 lod 2,2101 5,5

0 Targeting