Protein : Qrob_P0706060.2 Q. robur
Protein Identifier  ? Qrob_P0706060.2 Organism . Name  Quercus robur
Score  95.1 Score Type  egn
Protein Description  (M=1) K02178 - checkpoint serine/threonine-protein kinase [EC:2.7.11.1] Code Enzyme  EC:2.7.11.1
Gene Prediction Quality  validated Protein length 

Sequence

Length: 554  
Kegg Orthology  K02178
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0004672 protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
GO:0006468 protein phosphorylation The process of introducing a phosphate group on to a protein.
GO:0007094 mitotic spindle assembly checkpoint A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.

45 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|mdm:103426133 10 553 + 544 Gaps:48 99.44 531 73.30 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1-like
blastp_kegg lcl|mdm:103405647 10 553 + 544 Gaps:48 99.44 531 73.30 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1
blastp_kegg lcl|vvi:100260743 1 553 + 553 Gaps:32 100.00 529 71.83 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1-like
blastp_kegg lcl|pxb:103928858 10 553 + 544 Gaps:48 99.44 531 72.16 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1
blastp_kegg lcl|pmum:103329086 1 552 + 552 Gaps:46 100.00 536 71.46 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1-like
blastp_kegg lcl|pper:PRUPE_ppa018571mg 1 552 + 552 Gaps:64 100.00 554 69.31 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_008143 1 553 + 553 Gaps:33 100.00 528 70.45 0.0 ATP binding protein kinases protein serine/threonine kinases isoform 1
blastp_kegg lcl|cmo:103495479 5 553 + 549 Gaps:32 98.68 532 68.00 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1
blastp_kegg lcl|csv:101211883 1 553 + 553 Gaps:35 100.00 532 67.29 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1-like
blastp_kegg lcl|gmx:100783171 16 553 + 538 Gaps:29 96.23 531 70.06 0.0 mitotic checkpoint serine/threonine-protein kinase BUB1-like
blastp_pdb 3e7e_A 167 544 + 378 Gaps:63 91.78 365 37.91 6e-52 mol:protein length:365 Mitotic checkpoint serine/threonine-protein k
blastp_pdb 4a1g_D 14 144 + 131 none 86.18 152 29.77 3e-11 mol:protein length:152 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN K
blastp_pdb 4a1g_C 14 144 + 131 none 86.18 152 29.77 3e-11 mol:protein length:152 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN K
blastp_pdb 4a1g_B 14 144 + 131 none 86.18 152 29.77 3e-11 mol:protein length:152 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN K
blastp_pdb 4a1g_A 14 144 + 131 none 86.18 152 29.77 3e-11 mol:protein length:152 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN K
blastp_pdb 2lah_A 14 144 + 131 none 81.88 160 29.77 3e-11 mol:protein length:160 Mitotic checkpoint serine/threonine-protein k
blastp_pdb 4aez_I 9 143 + 135 Gaps:7 61.88 223 28.99 4e-08 mol:protein length:223 MITOTIC SPINDLE CHECKPOINT COMPONENT MAD3
blastp_pdb 4aez_F 9 143 + 135 Gaps:7 61.88 223 28.99 4e-08 mol:protein length:223 MITOTIC SPINDLE CHECKPOINT COMPONENT MAD3
blastp_pdb 4aez_C 9 143 + 135 Gaps:7 61.88 223 28.99 4e-08 mol:protein length:223 MITOTIC SPINDLE CHECKPOINT COMPONENT MAD3
blastp_uniprot_sprot sp|F4IVI0|BUB1_ARATH 12 553 + 542 Gaps:33 98.86 525 62.43 0.0 Mitotic checkpoint serine/threonine-protein kinase BUB1 OS Arabidopsis thaliana GN BUB1 PE 1 SV 1
blastp_uniprot_sprot sp|O43683|BUB1_HUMAN 14 544 + 531 Gaps:63 42.95 1085 35.41 6e-49 Mitotic checkpoint serine/threonine-protein kinase BUB1 OS Homo sapiens GN BUB1 PE 1 SV 1
blastp_uniprot_sprot sp|O08901|BUB1_MOUSE 13 544 + 532 Gaps:58 43.86 1058 34.27 8e-48 Mitotic checkpoint serine/threonine-protein kinase BUB1 OS Mus musculus GN Bub1 PE 2 SV 1
blastp_uniprot_sprot sp|P41695|BUB1_YEAST 167 524 + 358 Gaps:53 33.79 1021 35.07 1e-44 Checkpoint serine/threonine-protein kinase BUB1 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN BUB1 PE 1 SV 2
blastp_uniprot_sprot sp|O94751|BUB1_SCHPO 230 507 + 278 Gaps:49 25.96 1044 35.42 5e-35 Checkpoint serine/threonine-protein kinase bub1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN bub1 PE 1 SV 1
blastp_uniprot_sprot sp|Q54CV5|BUB1_DICDI 16 550 + 535 Gaps:52 33.00 1306 29.70 2e-20 Probable inactive serine/threonine-protein kinase bub1 OS Dictyostelium discoideum GN bub1 PE 3 SV 1
blastp_uniprot_sprot sp|O22806|BUBR1_ARATH 10 148 + 139 Gaps:4 35.70 395 32.62 3e-13 Mitotic spindle checkpoint protein BUBR1 OS Arabidopsis thaliana GN BUBR1 PE 1 SV 2
blastp_uniprot_sprot sp|O60566|BUB1B_HUMAN 214 509 + 296 Gaps:66 23.62 1050 30.24 4e-11 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS Homo sapiens GN BUB1B PE 1 SV 3
blastp_uniprot_sprot sp|Q9Z1S0|BUB1B_MOUSE 248 509 + 262 Gaps:62 20.53 1052 28.70 3e-07 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS Mus musculus GN Bub1b PE 1 SV 2
blastp_uniprot_sprot sp|O59767|MAD3_SCHPO 9 143 + 135 Gaps:7 44.52 310 28.99 4e-07 Mitotic spindle checkpoint component mad3 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN mad3 PE 1 SV 2
rpsblast_cdd gnl|CDD|173623 230 464 + 235 Gaps:51 86.51 215 26.34 6e-15 cd00180 PKc Catalytic domain of Protein Kinases. Protein Kinases (PKs) catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases aminoglycoside phosphotransferase choline kinase phosphoinositide 3-kinase (PI3K) and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases protein tyrosine kinases (PTKs) and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation about 95% occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins such as enzymes and membrane channels are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase which in turn may act on other kinases this sequential action transmits a signal from the cell surface to target proteins which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate tissue distribution and cellular localization. PKs regulate many cellular processes including proliferation division differentiation motility survival metabolism cell-cycle progression cytoskeletal rearrangement immunity and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer.

16 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SMART 223 525 303 SM00220 none Serine/Threonine protein kinases, catalytic domain IPR002290
ProSitePatterns 372 384 13 PS00108 none Serine/Threonine protein kinases active-site signature. IPR008271
Gene3D 221 330 110 G3DSA:3.30.200.20 none none none
Phobius 278 301 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 305 553 249 PTHR14030 "Reactome:REACT_152","Reactome:REACT_383";signature_desc=MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 none IPR015661
PANTHER 161 276 116 PTHR14030 "Reactome:REACT_152","Reactome:REACT_383";signature_desc=MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 none IPR015661
Gene3D 331 467 137 G3DSA:1.10.510.10 none none none
Phobius 302 553 252 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 1 277 277 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
SUPERFAMILY 220 289 70 SSF56112 none none IPR011009
SUPERFAMILY 320 511 192 SSF56112 none none IPR011009
ProSiteProfiles 223 553 331 PS50011 none Protein kinase domain profile. IPR000719
SMART 1 120 120 SM00777 "Reactome:REACT_152","Reactome:REACT_383" Mad3/BUB1 hoMad3/BUB1 homology region 1 IPR013212
Pfam 11 120 110 PF08311 "Reactome:REACT_152","Reactome:REACT_383" Mad3/BUB1 homology region 1 IPR013212
Pfam 223 471 249 PF00069 none Protein kinase domain IPR000719
ProSiteProfiles 1 159 159 PS51489 "Reactome:REACT_152","Reactome:REACT_383" BUB1 N-terminal domain profile. IPR013212

0 Localization

16 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran_2000_2002_QTL3_Delta.F Qrob_Chr08 8 s_1A3EF7_1406 s_1AIWYC_607 30.17 21,01 40,21 lod 6.8553 0.055
Bourran2_2014_aSeqBC_A4 Qrob_Chr08 8 v_15999_278 v_AP13YL15_395 32,52 4,22 57,22 lod 2,7561 6,7
Bourran2_2014_nFork*_A4 Qrob_Chr08 8 PIE175 s_1CD7GJ_1398 31,22 5,24 57,24 lod 2,6724 6,8
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Bourran2_2014_nPriLBD_A4 Qrob_Chr08 8 PIE175 v_9164_159 31,85 15,39 48,29 lod 2,8308 6,8
Bourran2_2015_rEpiBC_3P Qrob_Chr08 8 s_A9TNV_543 v_11837_70 9,93 9,83 11,15 lod 3.3 7.3
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL3_d13Cf Qrob_Chr08 8 v_5216_549 v_11625_20 37.08 12,26 54,9 lod 6.5888 0.04
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting