Protein : Qrob_P0701920.2 Q. robur
Protein Identifier  ? Qrob_P0701920.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=4) 3.1.26.4 - Ribonuclease H. Code Enzyme  EC:3.1.26.4
Gene Prediction Quality  validated Protein length 

Sequence

Length: 204  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0004523 RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

14 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_030014 1 197 + 197 Gaps:2 68.42 285 75.38 5e-104 Polynucleotidyl transferase
blastp_kegg lcl|rcu:RCOM_1096450 1 203 + 203 Gaps:2 100.00 201 72.14 6e-104 nuclease putative
blastp_kegg lcl|pmum:103324703 1 201 + 201 Gaps:3 99.00 200 69.70 9e-98 putative ribonuclease H protein At1g65750
blastp_kegg lcl|gmx:100785665 1 201 + 201 Gaps:3 98.51 201 70.20 4e-96 putative ribonuclease H protein At1g65750-like
blastp_kegg lcl|pop:POPTR_0004s03265g 1 203 + 203 Gaps:1 100.00 202 68.32 2e-95 POPTRDRAFT_858463 hypothetical protein
blastp_kegg lcl|mdm:103446491 1 203 + 203 Gaps:1 100.00 204 67.16 1e-92 putative ribonuclease H protein At1g65750
blastp_kegg lcl|mdm:103412449 1 201 + 201 Gaps:2 98.51 202 67.34 2e-91 uncharacterized LOC103412449
blastp_kegg lcl|pper:PRUPE_ppa019260mg 35 201 + 167 none 98.82 169 74.25 5e-89 hypothetical protein
blastp_kegg lcl|cam:101508262 1 201 + 201 Gaps:4 98.53 204 64.68 6e-86 uncharacterized LOC101508262
blastp_kegg lcl|aly:ARALYDRAFT_329467 1 203 + 203 Gaps:2 100.00 201 57.21 1e-81 At4g21420
blastp_uniprot_sprot sp|P0C2F6|RNHX1_ARATH 36 198 + 163 Gaps:3 26.13 620 29.63 2e-14 Putative ribonuclease H protein At1g65750 OS Arabidopsis thaliana GN At1g65750 PE 3 SV 1
rpsblast_cdd gnl|CDD|187690 47 170 + 124 Gaps:1 100.00 123 34.15 2e-24 cd06222 RNase_H RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. Ribonuclease H (RNase H) enzymes are divided into two major families Type 1 and Type 2 based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms including bacteria archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology Type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.
rpsblast_cdd gnl|CDD|205634 86 171 + 86 Gaps:1 96.59 88 31.76 4e-15 pfam13456 RVT_3 Reverse transcriptase-like. This domain is found in plants and appears to be part of a retrotransposon.
rpsblast_cdd gnl|CDD|187703 45 169 + 125 Gaps:2 97.66 128 28.00 4e-13 cd09279 RNase_HI_archaeal_like RNAse HI family that includes Archaeal RNase HI. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families type 1 (prokaryotic RNase HI eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication repair and transcription. RNase H is widely present in various organisms including bacteria archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology Type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII) however a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif they lack other common features important for catalytic function such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.

4 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 42 167 126 SSF53098 none none IPR012337
ProSiteProfiles 40 171 132 PS50879 none RNase H domain profile. IPR002156
Pfam 87 171 85 PF13456 none Reverse transcriptase-like none
Gene3D 48 171 124 G3DSA:3.30.420.10 none none IPR012337

0 Localization

0 Qtllist

0 Targeting