Protein : Qrob_P0647940.2 Q. robur
Protein Identifier  ? Qrob_P0647940.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K04712 - sphingolipid delta-4 desaturase [EC:1.14.-.-] Gene Prediction Quality  validated
Protein length 

Sequence

Length: 295  
Kegg Orthology  K04712
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0030148 sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
GO:0042284 sphingolipid delta-4 desaturase activity Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa008431mg 23 294 + 272 none 81.93 332 89.34 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_029899 23 294 + 272 none 72.34 376 88.24 2e-180 Fatty acid desaturase family protein isoform 1
blastp_kegg lcl|fve:101307465 23 294 + 272 none 82.93 328 88.24 2e-179 sphingolipid delta(4)-desaturase DES1-like
blastp_kegg lcl|rcu:RCOM_0935980 23 294 + 272 Gaps:4 82.63 334 88.41 6e-179 sphingolipid delta 4 desaturase/C-4 hydroxylase protein des2 putative
blastp_kegg lcl|pmum:103324743 23 294 + 272 none 83.18 327 88.60 4e-178 sphingolipid delta(4)-desaturase DES1
blastp_kegg lcl|sot:102583804 23 291 + 269 none 81.02 332 88.85 1e-177 sphingolipid delta(4)-desaturase DES1-like
blastp_kegg lcl|sly:543709 23 291 + 269 none 81.02 332 88.48 2e-177 uncharacterized LOC543709
blastp_kegg lcl|mdm:103446428 23 294 + 272 none 82.93 328 87.50 6e-177 sphingolipid delta(4)-desaturase DES1
blastp_kegg lcl|csv:101224821 23 294 + 272 none 83.95 324 87.13 2e-176 sphingolipid delta(4)-desaturase DES1-like
blastp_kegg lcl|csv:101207762 23 294 + 272 none 83.95 324 87.13 2e-176 sphingolipid delta(4)-desaturase DES1-like
blastp_uniprot_sprot sp|Q3ZBY7|DEGS1_BOVIN 23 294 + 272 Gaps:2 84.83 323 54.38 5e-101 Sphingolipid delta(4)-desaturase DES1 OS Bos taurus GN DEGS1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6UQ04|DEGS1_MICFO 23 294 + 272 Gaps:2 84.83 323 53.28 4e-96 Sphingolipid delta(4)-desaturase DES1 OS Microtus fortis GN DEGS1 PE 2 SV 1
blastp_uniprot_sprot sp|Q5F3C1|DEGS1_CHICK 23 291 + 269 Gaps:2 83.90 323 51.66 4e-96 Sphingolipid delta(4)-desaturase DES1 OS Gallus gallus GN DEGS1 PE 2 SV 1
blastp_uniprot_sprot sp|O15121|DEGS1_HUMAN 23 291 + 269 Gaps:2 83.90 323 52.77 9e-96 Sphingolipid delta(4)-desaturase DES1 OS Homo sapiens GN DEGS1 PE 1 SV 1
blastp_uniprot_sprot sp|Q5XIF5|DEGS1_RAT 1 294 + 294 Gaps:10 89.16 323 51.04 2e-95 Sphingolipid delta(4)-desaturase DES1 OS Rattus norvegicus GN Degs1 PE 2 SV 1
blastp_uniprot_sprot sp|Q5RE51|DEGS1_PONAB 23 291 + 269 Gaps:2 83.90 323 52.77 7e-95 Sphingolipid delta(4)-desaturase DES1 OS Pongo abelii GN DEGS1 PE 2 SV 1
blastp_uniprot_sprot sp|O09005|DEGS1_MOUSE 23 294 + 272 Gaps:2 84.83 323 52.19 1e-94 Sphingolipid delta(4)-desaturase DES1 OS Mus musculus GN Degs1 PE 2 SV 1
blastp_uniprot_sprot sp|G5EC63|DEGS2_CAEEL 18 291 + 274 Gaps:2 76.24 362 49.64 7e-93 Putative sphingolipid delta(4)-desaturase/C4-hydroxylase OS Caenorhabditis elegans GN ttm-5 PE 3 SV 1
blastp_uniprot_sprot sp|Q68FB8|DEGS1_XENTR 23 293 + 271 Gaps:2 84.52 323 49.45 2e-92 Sphingolipid delta(4)-desaturase DES1 OS Xenopus tropicalis GN degs1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6QHC5|DEGS2_HUMAN 30 288 + 259 Gaps:2 80.80 323 48.28 5e-87 Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 OS Homo sapiens GN DEGS2 PE 2 SV 2
rpsblast_cdd gnl|CDD|178191 23 292 + 270 none 83.59 323 82.96 1e-156 PLN02579 PLN02579 sphingolipid delta-4 desaturase.
rpsblast_cdd gnl|CDD|58174 17 289 + 273 Gaps:1 94.81 289 61.68 1e-114 cd03508 Delta4-sphingolipid-FADS-like The Delta4-sphingolipid Fatty Acid Desaturase (Delta4-sphingolipid-FADS)-like CD includes the integral-membrane enzymes dihydroceramide Delta-4 desaturase involved in the synthesis of sphingosine and the human membrane fatty acid (lipid) desaturase (MLD) reported to modulate biosynthesis of the epidermal growth factor receptor and other related proteins. These proteins are found in various eukaryotes including vertebrates higher plants and fungi. Studies show that MLD is localized to the endoplasmic reticulum. As with other members of this superfamily this domain family has extensive hydrophobic regions that would be capable of spanning the membrane bilayer at least twice. Comparison of sequences also reveals the existence of three regions of conserved histidine cluster motifs that contain eight histidine residues: HXXXH HXXHH and HXXHH. These histidine residues are reported to be catalytically essential and proposed to be the ligands for the iron atoms contained within the homolog stearoyl CoA desaturase..
rpsblast_cdd gnl|CDD|201259 42 259 + 218 Gaps:24 95.62 251 19.17 9e-16 pfam00487 FA_desaturase Fatty acid desaturase.
rpsblast_cdd gnl|CDD|33051 22 278 + 257 Gaps:26 81.92 343 20.64 2e-14 COG3239 DesA Fatty acid desaturase [Lipid metabolism].
rpsblast_kog gnl|CDD|38198 23 294 + 272 Gaps:2 84.57 324 64.23 1e-118 KOG2987 KOG2987 KOG2987 Fatty acid desaturase [Lipid transport and metabolism].

19 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PIRSF 11 294 284 PIRSF017228 "Reactome:REACT_22258" none IPR011388
Phobius 99 125 27 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 126 146 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 205 294 90 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 7 15 9 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
Phobius 179 183 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 23 294 272 PTHR12879:SF7 none none none
Phobius 16 20 5 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
Pfam 46 259 214 PF00487 none Fatty acid desaturase IPR005804
Phobius 21 35 15 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 36 56 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 158 178 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 57 76 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 1 20 20 SIGNAL_PEPTIDE none Signal peptide region none
PANTHER 23 294 272 PTHR12879 none none none
Phobius 1 6 6 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
Phobius 147 157 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 77 98 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 184 204 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

5 Localization

Analysis Start End Length
TMHMM 172 194 22
TMHMM 134 151 17
TMHMM 42 64 22
TMHMM 77 99 22
TMHMM 7 29 22

2 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC_3P Qrob_Chr05 5 s_2GDU0O_517 s_1BT8O3_239 25,81 0 55,45 lod 2,2101 5,5

0 Targeting