Protein : Qrob_P0638240.2 Q. robur
Protein Identifier  ? Qrob_P0638240.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=2) 3.1.13.5 - Ribonuclease D. Code Enzyme  EC:3.1.13.5
Gene Prediction Quality  validated Protein length 

Sequence

Length: 337  
Kegg Orthology  K18740
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0003723 RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

31 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100263418 1 336 + 336 none 100.00 336 82.44 0.0 uncharacterized LOC100263418
blastp_kegg lcl|vvi:100259526 1 336 + 336 Gaps:1 98.83 341 79.82 0.0 uncharacterized LOC100259526
blastp_kegg lcl|rcu:RCOM_0798510 2 336 + 335 Gaps:1 98.25 342 77.68 0.0 3'-5' exonuclease putative
blastp_kegg lcl|pper:PRUPE_ppa008192mg 2 336 + 335 none 97.95 342 76.72 0.0 hypothetical protein
blastp_kegg lcl|pmum:103320522 2 336 + 335 Gaps:1 97.96 343 76.79 0.0 exosome component 10
blastp_kegg lcl|cic:CICLE_v10008867mg 1 336 + 336 Gaps:5 98.81 335 76.44 0.0 hypothetical protein
blastp_kegg lcl|cit:102615602 1 336 + 336 Gaps:5 98.81 335 76.44 0.0 hypothetical protein
blastp_kegg lcl|csv:101223734 1 336 + 336 Gaps:1 99.12 340 75.07 0.0 uncharacterized LOC101223734
blastp_kegg lcl|csv:101214970 1 336 + 336 Gaps:1 99.12 340 75.07 0.0 uncharacterized LOC101214970
blastp_kegg lcl|pxb:103929643 6 336 + 331 none 96.50 343 76.13 0.0 uncharacterized LOC103929643
blastp_pdb 3sah_B 70 224 + 155 Gaps:20 31.54 428 33.33 6e-08 mol:protein length:428 Exosome component 10
blastp_pdb 3sah_A 70 224 + 155 Gaps:20 31.54 428 33.33 6e-08 mol:protein length:428 Exosome component 10
blastp_pdb 3sag_B 70 224 + 155 Gaps:20 31.54 428 32.59 4e-07 mol:protein length:428 Exosome component 10
blastp_pdb 3sag_A 70 224 + 155 Gaps:20 31.54 428 32.59 4e-07 mol:protein length:428 Exosome component 10
blastp_pdb 3saf_B 70 224 + 155 Gaps:20 31.54 428 32.59 4e-07 mol:protein length:428 Exosome component 10
blastp_pdb 3saf_A 70 224 + 155 Gaps:20 31.54 428 32.59 4e-07 mol:protein length:428 Exosome component 10
blastp_uniprot_sprot sp|Q8CDF7|EXD1_MOUSE 52 201 + 150 Gaps:10 26.67 570 34.21 2e-16 Exonuclease 3'-5' domain-containing protein 1 OS Mus musculus GN Exd1 PE 2 SV 1
blastp_uniprot_sprot sp|Q8NHP7|EXD1_HUMAN 52 201 + 150 Gaps:10 29.57 514 34.87 4e-16 Exonuclease 3'-5' domain-containing protein 1 OS Homo sapiens GN EXD1 PE 2 SV 4
blastp_uniprot_sprot sp|Q6NRD5|EXD1_XENLA 52 221 + 170 Gaps:14 38.74 444 30.23 8e-13 Exonuclease 3'-5' domain-containing protein 1 OS Xenopus laevis GN exd1 PE 2 SV 1
blastp_uniprot_sprot sp|P56960|EXOSX_MOUSE 70 228 + 159 Gaps:20 15.67 887 31.65 4e-07 Exosome component 10 OS Mus musculus GN Exosc10 PE 1 SV 2
blastp_uniprot_sprot sp|Q01780|EXOSX_HUMAN 70 224 + 155 Gaps:20 15.25 885 32.59 3e-06 Exosome component 10 OS Homo sapiens GN EXOSC10 PE 1 SV 2
blastp_uniprot_sprot sp|Q0P3U3|EXD1_DANRE 72 163 + 92 Gaps:1 24.60 378 33.33 8e-06 Exonuclease 3'-5' domain-containing protein 1 OS Danio rerio GN exd1 PE 2 SV 1
rpsblast_cdd gnl|CDD|99851 46 241 + 196 Gaps:4 99.49 197 43.88 2e-62 cd06148 Egl_like_exo DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins. The Egalitarian (Egl) protein subfamily is composed of Drosophila Egl and similar proteins. Egl is a component of an mRNA-binding complex which is required for oocyte specification. Egl contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. The motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The conservation of this subfamily throughout eukaryotes suggests that its members may be part of ancient RNA processing complexes that are likely to participate in the regulated processing of specific mRNAs. Some members of this subfamily do not have a completely conserved YX(3)D pattern at the ExoIII motif.
rpsblast_cdd gnl|CDD|176654 56 230 + 175 Gaps:21 87.64 178 32.69 4e-23 cd06142 RNaseD_exo DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins. Ribonuclease (RNase) D is a bacterial enzyme involved in the maturation of small stable RNAs and the 3' maturation of tRNA. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. In vivo RNase D only becomes essential upon removal of other ribonucleases. Eukaryotic RNase D homologs include yeast Rrp6p human PM/Scl-100 and the Drosophila melanogaster egalitarian protein.
rpsblast_cdd gnl|CDD|28891 56 221 + 166 Gaps:14 99.35 155 30.52 1e-20 cd00007 35EXOc 3'-5' exonuclease. The 35EXOc domain is responsible for the 3'-5' exonuclease proofreading activity of prokaryotic DNA polymerase I (pol I) and other enzymes it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli pol I. 35EXOc is also found in the Werner syndrome helicase (WRN) focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D)..
rpsblast_cdd gnl|CDD|201888 33 221 + 189 Gaps:24 99.42 172 35.67 1e-19 pfam01612 DNA_pol_A_exo1 3'-5' exonuclease. This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes it catalyzes the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN) focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.
rpsblast_cdd gnl|CDD|197748 33 221 + 189 Gaps:22 99.42 172 29.82 7e-18 smart00474 35EXOc 3'-5' exonuclease. 3\' -5' exonuclease proofreading domain present in DNA polymerase I Werner syndrome helicase RNase D and other enzymes.
rpsblast_cdd gnl|CDD|30697 57 230 + 174 Gaps:20 43.21 361 28.21 4e-14 COG0349 Rnd Ribonuclease D [Translation ribosomal structure and biogenesis].
rpsblast_cdd gnl|CDD|176653 52 223 + 172 Gaps:41 91.18 170 29.03 7e-08 cd06141 WRN_exo DEDDy 3'-5' exonuclease domain of WRN and similar proteins. WRN is a unique RecQ DNA helicase exhibiting an exonuclease activity. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Mutations in the WRN gene cause Werner syndrome an autosomal recessive disorder associated with premature aging and increased susceptibility to cancer and type II diabetes. WRN interacts with key proteins involved in DNA replication recombination and repair. It is believed to maintain genomic stability and life span by participating in DNA processes. WRN is stimulated by Ku70/80 an important regulator of genomic stability.
rpsblast_cdd gnl|CDD|180237 52 144 + 93 Gaps:4 10.80 880 27.37 6e-07 PRK05755 PRK05755 DNA polymerase I Provisional.

10 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SMART 33 222 190 SM00474 none 3'-5' exonuclease IPR002562
Pfam 274 330 57 PF00013 none KH domain IPR004088
SUPERFAMILY 28 244 217 SSF53098 none none IPR012337
Gene3D 266 334 69 G3DSA:3.30.1370.10 none none IPR004088
SMART 269 333 65 SM00322 none K homology RNA-binding domain IPR004087
PANTHER 28 289 262 PTHR12124 none none none
ProSiteProfiles 270 332 63 PS50084 none Type-1 KH domain profile. IPR004088
SUPERFAMILY 265 334 70 SSF54791 none none IPR004088
Pfam 53 221 169 PF01612 none 3'-5' exonuclease IPR002562
Gene3D 51 229 179 G3DSA:3.30.420.10 none none IPR012337

0 Localization

0 Qtllist

0 Targeting