Protein : Qrob_P0615920.2 Q. robur
Protein Identifier  ? Qrob_P0615920.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K01824 - cholestenol delta-isomerase [EC:5.3.3.5] Gene Prediction Quality  validated
Protein length 

Sequence

Length: 225  
Kegg Orthology  K01824
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0016125 sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
GO:0047750 cholestenol delta-isomerase activity Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol.

21 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|fve:101305754 1 224 + 224 none 100.00 224 76.79 2e-124 probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase-like
blastp_kegg lcl|cit:102606772 9 224 + 216 none 99.54 217 79.17 4e-122 probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase-like
blastp_kegg lcl|mdm:103452509 1 224 + 224 Gaps:6 100.00 230 80.87 6e-120 probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase
blastp_kegg lcl|pxb:103944742 1 224 + 224 Gaps:6 100.00 230 80.00 6e-119 probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase
blastp_kegg lcl|rcu:RCOM_1438730 1 222 + 222 Gaps:4 99.09 220 76.61 2e-117 sterol isomerase putative (EC:5.3.3.5)
blastp_kegg lcl|pop:POPTR_0003s15880g 1 224 + 224 Gaps:4 100.00 220 77.73 2e-116 POPTRDRAFT_554665 3-beta-hydroxysteroid-delta(8) family protein
blastp_kegg lcl|vvi:100263963 1 224 + 224 Gaps:2 100.00 222 80.63 7e-116 probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase-like
blastp_kegg lcl|gmx:100783250 8 224 + 217 Gaps:3 99.54 219 75.69 6e-115 probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase-like
blastp_kegg lcl|tcc:TCM_003533 9 224 + 216 none 99.54 217 73.15 2e-113 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase isoform 2
blastp_kegg lcl|pmum:103322172 1 224 + 224 Gaps:2 100.00 226 81.86 3e-112 probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase
blastp_uniprot_sprot sp|Q9FTZ2|EBP_ORYSJ 8 222 + 215 Gaps:2 98.17 219 63.72 2e-96 Probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase OS Oryza sativa subsp. japonica GN Os01g0103600 PE 2 SV 1
blastp_uniprot_sprot sp|O48962|EBP_ARATH 10 222 + 213 Gaps:9 97.76 223 65.60 8e-89 Probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase OS Arabidopsis thaliana GN At1g20050 PE 2 SV 1
blastp_uniprot_sprot sp|Q9JJ46|EBP_RAT 10 224 + 215 Gaps:5 94.78 230 36.70 3e-40 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase OS Rattus norvegicus GN Ebp PE 2 SV 3
blastp_uniprot_sprot sp|P70245|EBP_MOUSE 10 224 + 215 Gaps:7 94.78 230 37.61 4e-40 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase OS Mus musculus GN Ebp PE 1 SV 3
blastp_uniprot_sprot sp|Q60490|EBP_CAVPO 1 223 + 223 Gaps:8 97.38 229 38.12 2e-36 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase OS Cavia porcellus GN EBP PE 1 SV 3
blastp_uniprot_sprot sp|Q15125|EBP_HUMAN 10 212 + 203 Gaps:11 89.57 230 36.89 3e-35 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase OS Homo sapiens GN EBP PE 1 SV 3
blastp_uniprot_sprot sp|Q9D0P0|EBPL_MOUSE 57 209 + 153 Gaps:3 75.73 206 33.97 3e-22 Emopamil-binding protein-like OS Mus musculus GN Ebpl PE 2 SV 1
blastp_uniprot_sprot sp|Q9BY08|EBPL_HUMAN 57 224 + 168 Gaps:3 83.01 206 30.41 2e-17 Emopamil-binding protein-like OS Homo sapiens GN EBPL PE 1 SV 1
blastp_uniprot_sprot sp|Q55E32|EBP_DICDI 37 213 + 177 Gaps:32 86.30 219 29.63 1e-13 Probable 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase OS Dictyostelium discoideum GN ebp PE 2 SV 1
rpsblast_cdd gnl|CDD|191242 32 214 + 183 Gaps:7 97.41 193 38.83 5e-51 pfam05241 EBP Emopamil binding protein. Emopamil binding protein (EBP) is as a gene that encodes a non-glycosylated type I integral membrane protein of endoplasmic reticulum and shows high level expression in epithelial tissues. The EBP protein has emopamil binding domains including the sterol acceptor site and the catalytic centre which show Delta8-Delta7 sterol isomerase activity. Human sterol isomerase a homologue of mouse EBP is suggested not only to play a role in cholesterol biosynthesis but also to affect lipoprotein internalisation. In humans mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.
rpsblast_kog gnl|CDD|40023 10 222 + 213 Gaps:5 94.32 229 44.44 1e-57 KOG4826 KOG4826 KOG4826 C-8 7 sterol isomerase [Lipid transport and metabolism].

14 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 85 115 31 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 63 84 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1 214 214 PTHR14207:SF0 none none none
Phobius 142 147 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 148 171 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 116 141 26 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 172 182 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 1 214 214 PTHR14207 none none IPR007905
Phobius 32 51 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 52 62 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 36 216 181 PF05241 none Emopamil binding protein IPR007905
Phobius 1 31 31 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 183 203 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 204 224 21 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none

5 Localization

Analysis Start End Length
TMHMM 147 169 22
TMHMM 32 54 22
TMHMM 184 206 22
TMHMM 118 140 22
TMHMM 63 85 22

4 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran_2000_2002_QTL6_Delta.F Qrob_Chr03 3 s_2HYXJ2_207 s_1AUAXK_317 29.12 6,3 45,37 lod 3.1666 0.026
Bourran2_2014_nLBD_3P Qrob_Chr03 3 s_1ET7H8_604 s_1BYNB5_834 23,73 0 46,72 lod 1,7573 3,8
PM_1999_QTL14_peak_Bud_burst_3P Qrob_Chr03 3 s_2F0SI1_756 v_6056_735 11,78 3,78 50,78 lod 2,5 4,5
Bourran2_2014_rEpiBC*_3P Qrob_Chr03 3 s_1A3B3X_1163 s_1DKGMO_450 23,04 4,92 41,12 lod 2,5668 7

0 Targeting