Protein : Qrob_P0612370.2 Q. robur

Protein Identifier  ? Qrob_P0612370.2 Organism . Name  Quercus robur
Score  20.2 Score Type  egn
Protein Description  (M=4) 1.14.13.132 - Squalene monooxygenase. Code Enzyme  EC:1.14.13.132
Gene Prediction Quality  validated Protein length 

Sequence

Length: 414  
Kegg Orthology  K00511

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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0050660 flavin adenine dinucleotide binding Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0004506 squalene monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|rcu:RCOM_0859900 14 410 + 397 Gaps:47 69.16 642 77.70 0.0 Squalene monooxygenase putative (EC:1.14.99.7)
blastp_kegg lcl|tcc:TCM_000850 14 409 + 396 Gaps:47 72.98 607 78.33 0.0 Squalene monooxygenase isoform 1
blastp_kegg lcl|cit:102616721 14 410 + 397 Gaps:47 72.31 614 77.03 0.0 squalene epoxidase 3-like
blastp_kegg lcl|mdm:103455855 14 407 + 394 Gaps:47 81.97 538 77.55 0.0 squalene monooxygenase
blastp_kegg lcl|pmum:103320605 14 407 + 394 Gaps:47 87.33 505 76.87 0.0 squalene monooxygenase-like
blastp_kegg lcl|pper:PRUPE_ppa003991mg 14 407 + 394 Gaps:47 82.28 536 77.10 0.0 hypothetical protein
blastp_kegg lcl|pxb:103951565 14 407 + 394 Gaps:47 81.97 538 77.32 0.0 squalene monooxygenase
blastp_kegg lcl|mdm:103443090 14 407 + 394 Gaps:47 82.12 537 77.10 0.0 squalene monooxygenase-like
blastp_kegg lcl|cic:CICLE_v10025367mg 14 410 + 397 Gaps:47 85.38 520 76.58 0.0 hypothetical protein
blastp_kegg lcl|fve:101297207 14 407 + 394 Gaps:47 81.52 541 76.87 0.0 squalene monooxygenase-like
blastp_uniprot_sprot sp|O48651|ERG1_PANGI 14 409 + 396 Gaps:47 82.19 539 70.43 0.0 Squalene monooxygenase OS Panax ginseng PE 2 SV 1
blastp_uniprot_sprot sp|Q8VYH2|ERG16_ARATH 14 406 + 393 Gaps:47 83.81 525 70.68 0.0 Squalene epoxidase 3 OS Arabidopsis thaliana GN SQE3 PE 1 SV 1
blastp_uniprot_sprot sp|Q9SM02|ERG14_ARATH 14 409 + 396 Gaps:48 83.62 531 68.69 0.0 Squalene epoxidase 1 OS Arabidopsis thaliana GN SQE1 PE 1 SV 1
blastp_uniprot_sprot sp|O81000|ERG15_ARATH 14 407 + 394 Gaps:47 75.38 585 68.93 0.0 Squalene epoxidase 2 mitochondrial OS Arabidopsis thaliana GN SQE2 PE 1 SV 1
blastp_uniprot_sprot sp|O65404|ERG11_ARATH 14 406 + 393 Gaps:50 85.85 516 44.24 6e-125 Squalene epoxidase 5 OS Arabidopsis thaliana GN SQE5 PE 2 SV 2
blastp_uniprot_sprot sp|O65402|ERG12_ARATH 14 406 + 393 Gaps:51 85.88 517 42.79 6e-124 Squalene epoxidase 6 OS Arabidopsis thaliana GN SQE6 PE 2 SV 1
blastp_uniprot_sprot sp|O65727|ERG11_BRANA 14 406 + 393 Gaps:60 85.18 506 44.55 7e-118 Squalene monooxygenase 1 1 OS Brassica napus GN SQP1 1 PE 2 SV 1
blastp_uniprot_sprot sp|O65726|ERG12_BRANA 14 406 + 393 Gaps:49 85.33 518 41.18 9e-117 Squalene monooxygenase 1 2 OS Brassica napus GN SQP1 2 PE 2 SV 1
blastp_uniprot_sprot sp|O65403|ERG13_ARATH 14 405 + 392 Gaps:52 86.05 516 40.54 2e-109 Squalene epoxidase 4 OS Arabidopsis thaliana GN SQE4 PE 2 SV 1
blastp_uniprot_sprot sp|Q14534|ERG1_HUMAN 14 389 + 376 Gaps:60 73.87 574 41.04 2e-86 Squalene monooxygenase OS Homo sapiens GN SQLE PE 1 SV 3
rpsblast_cdd gnl|CDD|178566 14 406 + 393 Gaps:50 86.19 514 43.57 1e-117 PLN02985 PLN02985 squalene monooxygenase.
rpsblast_cdd gnl|CDD|192047 143 369 + 227 Gaps:51 100.00 276 48.19 6e-92 pfam08491 SE Squalene epoxidase. This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway. Putative transmembrane regions are found to the protein's C-terminus.
rpsblast_cdd gnl|CDD|185578 15 392 + 378 Gaps:125 83.77 567 34.32 1e-88 PTZ00367 PTZ00367 squalene epoxidase Provisional.
rpsblast_cdd gnl|CDD|30999 15 307 + 293 Gaps:32 77.26 387 18.06 3e-13 COG0654 UbiH 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].
rpsblast_kog gnl|CDD|36512 14 407 + 394 Gaps:48 86.84 509 62.22 1e-172 KOG1298 KOG1298 KOG1298 Squalene monooxygenase [Lipid transport and metabolism].

14 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 148 283 136 PF08491 "KEGG:00100+1.14.13.132","KEGG:00909+1.14.13.132","MetaCyc:PWY-5670","MetaCyc:PWY-6098","UniPathway:UPA00767" Squalene epoxidase IPR013698
Pfam 285 369 85 PF08491 "KEGG:00100+1.14.13.132","KEGG:00909+1.14.13.132","MetaCyc:PWY-5670","MetaCyc:PWY-6098","UniPathway:UPA00767" Squalene epoxidase IPR013698
Phobius 368 387 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 363 367 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 315 336 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 388 413 26 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 1 314 314 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 14 407 394 PTHR10835 none none none
Phobius 343 362 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 337 342 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Gene3D 14 169 156 G3DSA:3.50.50.60 none none none
Gene3D 252 289 38 G3DSA:3.50.50.60 none none none
SUPERFAMILY 241 315 75 SSF51905 none none none
SUPERFAMILY 15 152 138 SSF51905 none none none

3 Localization

Analysis Start End Length
TMHMM 314 336 22
TMHMM 343 365 22
TMHMM 369 391 22

0 Qtllist

0 Targeting