Protein : Qrob_P0612360.2 Q. robur
Protein Identifier  ? Qrob_P0612360.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=4) 1.14.13.132 - Squalene monooxygenase. Code Enzyme  EC:1.14.13.132
Gene Prediction Quality  validated Protein length 

Sequence

Length: 630  
Kegg Orthology  K00511
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0050660 flavin adenine dinucleotide binding Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0004506 squalene monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_000850 38 625 + 588 Gaps:21 99.01 607 77.04 0.0 Squalene monooxygenase isoform 1
blastp_kegg lcl|rcu:RCOM_0859900 104 626 + 523 Gaps:9 80.37 642 86.63 0.0 Squalene monooxygenase putative (EC:1.14.99.7)
blastp_kegg lcl|pop:POPTR_0007s14670g 19 625 + 607 Gaps:22 97.55 612 77.72 0.0 POPTRDRAFT_832433 hypothetical protein
blastp_kegg lcl|vvi:100262930 103 626 + 524 Gaps:8 99.23 522 82.63 0.0 squalene monooxygenase-like
blastp_kegg lcl|cit:102616721 82 626 + 545 Gaps:10 87.79 614 81.82 0.0 squalene epoxidase 3-like
blastp_kegg lcl|vvi:100854014 10 626 + 617 Gaps:22 98.84 606 74.79 0.0 squalene monooxygenase-like
blastp_kegg lcl|tcc:TCM_034641 101 626 + 526 Gaps:9 99.62 523 80.81 0.0 Squalene monooxygenase isoform 1
blastp_kegg lcl|pmum:103336172 97 626 + 530 Gaps:16 85.13 632 80.86 0.0 squalene epoxidase 3-like
blastp_kegg lcl|pper:PRUPE_ppa003900mg 97 626 + 530 Gaps:12 99.45 541 81.04 0.0 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10025367mg 100 626 + 527 Gaps:8 99.81 520 83.43 0.0 hypothetical protein
blastp_pdb 2x3n_A 158 466 + 309 Gaps:36 77.44 399 25.57 7e-11 mol:protein length:399 PROBABLE FAD-DEPENDENT MONOOXYGENASE
blastp_uniprot_sprot sp|O48651|ERG1_PANGI 130 625 + 496 Gaps:4 91.28 539 78.66 0.0 Squalene monooxygenase OS Panax ginseng PE 2 SV 1
blastp_uniprot_sprot sp|O81000|ERG15_ARATH 83 623 + 541 Gaps:15 89.91 585 75.67 0.0 Squalene epoxidase 2 mitochondrial OS Arabidopsis thaliana GN SQE2 PE 1 SV 1
blastp_uniprot_sprot sp|Q9SM02|ERG14_ARATH 159 625 + 467 Gaps:1 88.14 531 80.13 0.0 Squalene epoxidase 1 OS Arabidopsis thaliana GN SQE1 PE 1 SV 1
blastp_uniprot_sprot sp|Q8VYH2|ERG16_ARATH 98 622 + 525 Gaps:16 97.33 525 76.91 0.0 Squalene epoxidase 3 OS Arabidopsis thaliana GN SQE3 PE 1 SV 1
blastp_uniprot_sprot sp|O65404|ERG11_ARATH 105 622 + 518 Gaps:22 97.29 516 49.80 2e-172 Squalene epoxidase 5 OS Arabidopsis thaliana GN SQE5 PE 2 SV 2
blastp_uniprot_sprot sp|O65402|ERG12_ARATH 103 622 + 520 Gaps:24 97.87 517 48.42 6e-167 Squalene epoxidase 6 OS Arabidopsis thaliana GN SQE6 PE 2 SV 1
blastp_uniprot_sprot sp|O65727|ERG11_BRANA 103 622 + 520 Gaps:33 97.43 506 50.30 1e-162 Squalene monooxygenase 1 1 OS Brassica napus GN SQP1 1 PE 2 SV 1
blastp_uniprot_sprot sp|O65726|ERG12_BRANA 159 622 + 464 Gaps:2 89.96 518 48.50 2e-162 Squalene monooxygenase 1 2 OS Brassica napus GN SQP1 2 PE 2 SV 1
blastp_uniprot_sprot sp|O65403|ERG13_ARATH 105 621 + 517 Gaps:24 97.48 516 46.32 2e-154 Squalene epoxidase 4 OS Arabidopsis thaliana GN SQE4 PE 2 SV 1
blastp_uniprot_sprot sp|Q14534|ERG1_HUMAN 158 605 + 448 Gaps:13 78.22 574 47.66 2e-121 Squalene monooxygenase OS Homo sapiens GN SQLE PE 1 SV 3
rpsblast_cdd gnl|CDD|178566 105 622 + 518 Gaps:22 97.67 514 49.40 1e-158 PLN02985 PLN02985 squalene monooxygenase.
rpsblast_cdd gnl|CDD|192047 312 585 + 274 Gaps:4 100.00 276 60.14 1e-131 pfam08491 SE Squalene epoxidase. This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway. Putative transmembrane regions are found to the protein's C-terminus.
rpsblast_cdd gnl|CDD|185578 163 608 + 446 Gaps:78 87.48 567 38.91 1e-120 PTZ00367 PTZ00367 squalene epoxidase Provisional.
rpsblast_cdd gnl|CDD|30999 162 552 + 391 Gaps:18 98.97 387 24.54 4e-39 COG0654 UbiH 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].
rpsblast_cdd gnl|CDD|30989 163 517 + 355 Gaps:38 88.64 396 22.22 2e-19 COG0644 FixC Dehydrogenases (flavoproteins) [Energy production and conversion].
rpsblast_cdd gnl|CDD|136171 158 512 + 355 Gaps:32 90.98 388 25.21 4e-16 PRK07045 PRK07045 putative monooxygenase Reviewed.
rpsblast_cdd gnl|CDD|180451 162 329 + 168 Gaps:40 41.28 407 29.76 2e-15 PRK06185 PRK06185 hypothetical protein Provisional.
rpsblast_cdd gnl|CDD|200151 163 465 + 303 Gaps:41 96.27 295 26.76 3e-14 TIGR02032 GG-red-SF geranylgeranyl reductase family. This HMM represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates.
rpsblast_cdd gnl|CDD|201827 162 502 + 341 Gaps:50 97.71 349 23.75 4e-12 pfam01494 FAD_binding_3 FAD binding domain. This domain is involved in FAD binding in a number of enzymes.

20 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 438 471 34 G3DSA:3.50.50.60 none none none
Gene3D 161 336 176 G3DSA:3.50.50.60 none none none
Phobius 534 552 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 126 623 498 PTHR10835 none none none
Phobius 553 558 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 1 103 103 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PRINTS 440 455 16 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
PRINTS 455 471 17 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
PRINTS 163 185 23 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
PRINTS 312 327 16 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
SUPERFAMILY 427 537 111 SSF51905 none none none
SUPERFAMILY 162 333 172 SSF51905 none none none
Phobius 559 578 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 122 533 412 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 166 192 27 PF13450 none NAD(P)-binding Rossmann-like domain none
Phobius 603 629 27 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 313 585 273 PF08491 "KEGG:00100+1.14.13.132","KEGG:00909+1.14.13.132","MetaCyc:PWY-5670","MetaCyc:PWY-6098","UniPathway:UPA00767" Squalene epoxidase IPR013698
Phobius 104 121 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 579 583 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 584 602 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

4 Localization

Analysis Start End Length
TMHMM 559 578 19
TMHMM 530 549 19
TMHMM 585 602 17
TMHMM 99 121 22

0 Qtllist

0 Targeting