Protein : Qrob_P0611120.2 Q. robur
Protein Identifier  ? Qrob_P0611120.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=4) 6.3.2.12 - Dihydrofolate synthase. Code Enzyme  EC:6.3.2.12
Gene Prediction Quality  validated Protein length 

Sequence

Length: 508  
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0009396 folic acid-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.
GO:0016874 ligase activity Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0004326 tetrahydrofolylpolyglutamate synthase activity Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).

36 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100267405 1 507 + 507 none 94.59 536 73.96 0.0 folylpolyglutamate synthase-like
blastp_kegg lcl|pper:PRUPE_ppa020012mg 1 500 + 500 Gaps:1 100.00 499 75.55 0.0 hypothetical protein
blastp_kegg lcl|pxb:103948060 1 507 + 507 Gaps:1 91.17 555 74.11 0.0 probable dihydrofolate synthetase
blastp_kegg lcl|pxb:103958166 1 507 + 507 Gaps:1 91.17 555 74.31 0.0 probable dihydrofolate synthetase
blastp_kegg lcl|pmum:103333670 1 505 + 505 Gaps:1 90.65 556 74.40 0.0 dihydrofolate synthetase
blastp_kegg lcl|mdm:103439847 1 505 + 505 Gaps:1 90.81 555 75.60 0.0 probable dihydrofolate synthetase
blastp_kegg lcl|cit:102611256 1 505 + 505 Gaps:1 90.65 556 71.63 0.0 folylpolyglutamate synthase mitochondrial-like
blastp_kegg lcl|cic:CICLE_v10007115mg 1 505 + 505 Gaps:1 89.20 565 71.63 0.0 hypothetical protein
blastp_kegg lcl|fve:101295861 1 507 + 507 Gaps:1 91.50 553 73.72 0.0 folylpolyglutamate synthase-like
blastp_kegg lcl|pop:POPTR_0015s06150g 1 505 + 505 Gaps:10 96.12 515 72.12 0.0 hypothetical protein
blastp_pdb 1o5z_A 29 400 + 372 Gaps:38 76.92 442 39.71 1e-58 mol:protein length:442 folylpolyglutamate synthase/dihydrofolate syn
blastp_pdb 1jbw_A 28 470 + 443 Gaps:50 92.76 428 29.47 7e-39 mol:protein length:428 FOLYLPOLYGLUTAMATE SYNTHASE
blastp_pdb 1jbv_A 28 470 + 443 Gaps:50 92.76 428 29.47 7e-39 mol:protein length:428 FOLYLPOLYGLUTAMATE SYNTHASE
blastp_pdb 1fgs_A 28 470 + 443 Gaps:50 92.76 428 29.47 7e-39 mol:protein length:428 FOLYLPOLYGLUTAMATE SYNTHETASE
blastp_pdb 2gca_A 28 470 + 443 Gaps:50 92.76 428 29.22 3e-38 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 2gc6_A 28 470 + 443 Gaps:50 92.76 428 28.97 8e-38 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 2gc5_A 28 470 + 443 Gaps:50 92.76 428 28.97 2e-37 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 2gcb_A 28 470 + 443 Gaps:50 92.76 428 28.72 2e-37 mol:protein length:428 Folylpolyglutamate synthase
blastp_pdb 3qcz_A 29 383 + 355 Gaps:68 74.83 437 36.39 2e-28 mol:protein length:437 Dihydrofolate synthase / folylpolyglutamate s
blastp_pdb 3pyz_A 29 383 + 355 Gaps:68 74.83 437 36.39 2e-28 mol:protein length:437 Bifunctional folylpolyglutamate synthase/dihy
blastp_uniprot_sprot sp|Q05865|FOLC_BACSU 29 381 + 353 Gaps:37 76.28 430 37.20 3e-53 Folylpolyglutamate synthase OS Bacillus subtilis (strain 168) GN folC PE 3 SV 2
blastp_uniprot_sprot sp|P15925|FOLC_LACCA 28 470 + 443 Gaps:50 92.76 428 29.22 1e-37 Folylpolyglutamate synthase OS Lactobacillus casei GN fgs PE 1 SV 1
blastp_uniprot_sprot sp|Q05932|FOLC_HUMAN 1 420 + 420 Gaps:133 66.27 587 33.16 2e-35 Folylpolyglutamate synthase mitochondrial OS Homo sapiens GN FPGS PE 1 SV 3
blastp_uniprot_sprot sp|Q09509|FOLC_CAEEL 26 502 + 477 Gaps:90 86.08 510 30.52 7e-35 Putative folylpolyglutamate synthase OS Caenorhabditis elegans GN F25B5.6 PE 3 SV 1
blastp_uniprot_sprot sp|A6H751|FOLC_BOVIN 1 361 + 361 Gaps:103 60.17 585 34.09 1e-34 Folylpolyglutamate synthase mitochondrial OS Bos taurus GN FPGS PE 2 SV 1
blastp_uniprot_sprot sp|Q924L9|FOLC_CRIGR 45 358 + 314 Gaps:86 50.43 587 34.80 2e-33 Folylpolyglutamate synthase mitochondrial OS Cricetulus griseus GN FPGS PE 2 SV 1
blastp_uniprot_sprot sp|Q12676|FOLD_YEAST 29 447 + 419 Gaps:48 89.23 427 30.18 3e-33 Dihydrofolate synthetase OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN FOL3 PE 1 SV 1
blastp_uniprot_sprot sp|P48760|FOLC_MOUSE 49 364 + 316 Gaps:74 50.77 587 33.89 3e-32 Folylpolyglutamate synthase mitochondrial OS Mus musculus GN Fpgs PE 1 SV 3
blastp_uniprot_sprot sp|P43775|FOLC_HAEIN 29 383 + 355 Gaps:49 74.60 437 31.60 1e-31 Folylpolyglutamate synthase OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN folC PE 3 SV 1
blastp_uniprot_sprot sp|Q9UTD0|FOLD_SCHPO 29 393 + 365 Gaps:44 79.86 417 34.53 3e-31 Probable dihydrofolate synthetase OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN fol3 PE 3 SV 1

18 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 269 431 163 PTHR11136:SF0 none none none
Phobius 506 507 2 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
TIGRFAM 29 503 475 TIGR01499 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850" folC: bifunctional protein FolC IPR001645
Gene3D 25 318 294 G3DSA:3.40.1190.10 "UniPathway:UPA00219" none IPR013221
Phobius 1 485 485 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 269 431 163 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
Pfam 51 296 246 PF08245 "UniPathway:UPA00219" Mur ligase middle domain IPR013221
PANTHER 8 250 243 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
PANTHER 455 505 51 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
Phobius 486 505 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 461 506 46 G3DSA:3.90.190.20 "UniPathway:UPA00219" none IPR004101
Gene3D 322 427 106 G3DSA:3.90.190.20 "UniPathway:UPA00219" none IPR004101
SUPERFAMILY 27 319 293 SSF53623 "UniPathway:UPA00219" none IPR013221
PANTHER 8 250 243 PTHR11136:SF0 none none none
PANTHER 455 505 51 PTHR11136:SF0 none none none
SUPERFAMILY 484 506 23 SSF53244 "UniPathway:UPA00219" none IPR004101
SUPERFAMILY 322 435 114 SSF53244 "UniPathway:UPA00219" none IPR004101
ProSitePatterns 149 164 16 PS01012 none Folylpolyglutamate synthase signature 2. IPR018109

0 Localization

7 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL4_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,45 0 27,45 lod 4,5 10,6
Bourran_2000_2002_QTL7_Delta.F Qrob_Chr09 9 v_5944_442 s_1BA1PC_866 23.51 10,96 35,74 lod 4.1466 0.041
Bourran2_2003_QTL11_peak_Bud_burst_3P Qrob_Chr09 9 s_1CGP2H_273 v_15801_330 27,16 4,16 48,16 lod 2,3 5,1
Bourran2_2004_QTL14_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,83 10,33 22,33 lod 3,8 9
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nSecLBD_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 35,81 34,88 37,45 lod 4.4 10.4
Bourran_2000_2002_QTL4_Delta.F Qrob_Chr09 9 s_1C1GRV_1289 v_12080_1202 2.56 0 13,73 lod 7.4808 0.051

0 Targeting