Protein : Qrob_P0611090.2 Q. robur
Protein Identifier  ? Qrob_P0611090.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=4) 6.3.2.12 - Dihydrofolate synthase. Code Enzyme  EC:6.3.2.12
Gene Prediction Quality  validated Protein length 

Sequence

Length: 229  
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0009396 folic acid-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.
GO:0016874 ligase activity Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0004326 tetrahydrofolylpolyglutamate synthase activity Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).

16 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100267405 1 228 + 228 none 42.54 536 60.53 4e-83 folylpolyglutamate synthase-like
blastp_kegg lcl|pmum:103333670 1 226 + 226 Gaps:7 40.47 556 61.33 7e-80 dihydrofolate synthetase
blastp_kegg lcl|pper:PRUPE_ppa020012mg 1 221 + 221 Gaps:5 44.09 499 61.82 2e-79 hypothetical protein
blastp_kegg lcl|pxb:103958166 1 228 + 228 Gaps:5 40.90 555 59.47 3e-77 probable dihydrofolate synthetase
blastp_kegg lcl|pxb:103948060 1 228 + 228 Gaps:5 40.90 555 59.47 6e-77 probable dihydrofolate synthetase
blastp_kegg lcl|pop:POPTR_0015s06150g 1 226 + 226 Gaps:38 41.94 515 62.50 2e-74 hypothetical protein
blastp_kegg lcl|cit:102611256 1 226 + 226 Gaps:5 40.47 556 58.67 3e-73 folylpolyglutamate synthase mitochondrial-like
blastp_kegg lcl|cic:CICLE_v10007115mg 1 226 + 226 Gaps:5 39.82 565 58.67 5e-73 hypothetical protein
blastp_kegg lcl|gmx:100793607 1 228 + 228 Gaps:8 42.54 536 58.77 2e-71 probable dihydrofolate synthetase-like
blastp_kegg lcl|mtr:MTR_7g100940 1 227 + 227 Gaps:16 46.02 502 56.28 6e-71 Folylpolyglutamate synthase
blastp_pdb 1o5z_A 1 109 + 109 Gaps:11 22.17 442 37.76 2e-11 mol:protein length:442 folylpolyglutamate synthase/dihydrofolate syn
blastp_uniprot_sprot sp|Q05865|FOLC_BACSU 1 102 + 102 Gaps:12 21.86 430 35.11 4e-06 Folylpolyglutamate synthase OS Bacillus subtilis (strain 168) GN folC PE 3 SV 2
rpsblast_cdd gnl|CDD|178501 1 228 + 228 Gaps:38 39.61 510 61.88 6e-64 PLN02913 PLN02913 dihydrofolate synthetase.
rpsblast_cdd gnl|CDD|200112 1 101 + 101 Gaps:9 23.62 398 39.36 4e-16 TIGR01499 folC folylpolyglutamate synthase/dihydrofolate synthase. This model represents the FolC family of folate pathway proteins. Most examples are bifunctional active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically) the model is treated as subfamily not equivalog.
rpsblast_cdd gnl|CDD|30633 1 123 + 123 Gaps:17 27.17 427 40.52 5e-16 COG0285 FolC Folylpolyglutamate synthase [Coenzyme metabolism].
rpsblast_kog gnl|CDD|37736 1 226 + 226 Gaps:29 44.96 496 25.56 2e-15 KOG2525 KOG2525 KOG2525 Folylpolyglutamate synthase [Coenzyme transport and metabolism].

13 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 43 121 79 G3DSA:3.90.190.20 "UniPathway:UPA00219" none IPR004101
Gene3D 154 226 73 G3DSA:3.90.190.20 "UniPathway:UPA00219" none IPR004101
Phobius 1 207 207 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 176 226 51 PTHR11136:SF0 none none none
PANTHER 1 152 152 PTHR11136:SF0 none none none
SUPERFAMILY 154 173 20 SSF53244 "UniPathway:UPA00219" none IPR004101
SUPERFAMILY 205 227 23 SSF53244 "UniPathway:UPA00219" none IPR004101
SUPERFAMILY 43 120 78 SSF53244 "UniPathway:UPA00219" none IPR004101
Phobius 208 226 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 227 228 2 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 1 152 152 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
PANTHER 176 226 51 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
Gene3D 2 39 38 G3DSA:3.40.1190.10 "UniPathway:UPA00219" none IPR013221

0 Localization

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL4_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,45 0 27,45 lod 4,5 10,6
Bourran_2000_2002_QTL7_Delta.F Qrob_Chr09 9 v_5944_442 s_1BA1PC_866 23.51 10,96 35,74 lod 4.1466 0.041
Bourran2_2004_QTL14_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,83 10,33 22,33 lod 3,8 9
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nSecLBD_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 35,81 34,88 37,45 lod 4.4 10.4
Bourran_2000_2002_QTL4_Delta.F Qrob_Chr09 9 s_1C1GRV_1289 v_12080_1202 2.56 0 13,73 lod 7.4808 0.051

0 Targeting