Protein : Qrob_P0611080.2 Q. robur
Protein Identifier  ? Qrob_P0611080.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=4) 6.3.2.12 - Dihydrofolate synthase. Code Enzyme  EC:6.3.2.12
Gene Prediction Quality  validated Protein length 

Sequence

Length: 222  
Paste the following link
Lists
This Protein isn't in any lists. Upload a list.

Sequence Feature Displayer

Protein Sequence Displayer

J Browse Displayer

0 Synonyms

4 GO Terms

Identifier Name Description
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0009396 folic acid-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.
GO:0004326 tetrahydrofolylpolyglutamate synthase activity Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).

24 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|mdm:103439847 49 218 + 170 Gaps:21 34.41 555 69.63 9e-80 probable dihydrofolate synthetase
blastp_kegg lcl|pper:PRUPE_ppa020012mg 49 218 + 170 Gaps:21 38.28 499 69.63 2e-79 hypothetical protein
blastp_kegg lcl|vvi:100267405 49 218 + 170 Gaps:21 35.63 536 68.06 3e-79 folylpolyglutamate synthase-like
blastp_kegg lcl|pmum:103333670 49 218 + 170 Gaps:21 34.35 556 67.54 2e-76 dihydrofolate synthetase
blastp_kegg lcl|pxb:103948060 49 218 + 170 Gaps:21 34.41 555 67.02 4e-76 probable dihydrofolate synthetase
blastp_kegg lcl|pxb:103958166 49 218 + 170 Gaps:21 34.41 555 66.49 1e-74 probable dihydrofolate synthetase
blastp_kegg lcl|fve:101295861 49 218 + 170 Gaps:21 34.54 553 65.45 1e-72 folylpolyglutamate synthase-like
blastp_kegg lcl|pvu:PHAVU_001G060700g 49 220 + 172 Gaps:21 49.61 389 63.21 1e-71 hypothetical protein
blastp_kegg lcl|mtr:MTR_7g100940 51 218 + 168 Gaps:22 37.45 502 65.43 2e-69 Folylpolyglutamate synthase
blastp_kegg lcl|cam:101503731 49 220 + 172 Gaps:21 35.41 545 63.21 8e-69 folylpolyglutamate synthase-like
blastp_pdb 1o5z_A 50 158 + 109 Gaps:26 28.28 442 34.40 6e-09 mol:protein length:442 folylpolyglutamate synthase/dihydrofolate syn
blastp_uniprot_sprot sp|Q05865|FOLC_BACSU 48 186 + 139 Gaps:28 36.05 430 32.26 1e-10 Folylpolyglutamate synthase OS Bacillus subtilis (strain 168) GN folC PE 3 SV 2
blastp_uniprot_sprot sp|Q05932|FOLC_HUMAN 47 180 + 134 Gaps:35 25.72 587 29.80 3e-09 Folylpolyglutamate synthase mitochondrial OS Homo sapiens GN FPGS PE 1 SV 3
blastp_uniprot_sprot sp|A6H751|FOLC_BOVIN 47 180 + 134 Gaps:36 25.98 585 30.26 6e-09 Folylpolyglutamate synthase mitochondrial OS Bos taurus GN FPGS PE 2 SV 1
blastp_uniprot_sprot sp|Q924L9|FOLC_CRIGR 47 180 + 134 Gaps:35 25.72 587 29.14 5e-08 Folylpolyglutamate synthase mitochondrial OS Cricetulus griseus GN FPGS PE 2 SV 1
blastp_uniprot_sprot sp|O74742|FOLE_SCHPO 49 173 + 125 Gaps:26 27.92 505 26.95 6e-08 Probable folylpolyglutamate synthase OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN met7 PE 2 SV 1
blastp_uniprot_sprot sp|P43775|FOLC_HAEIN 49 164 + 116 Gaps:15 28.60 437 32.00 8e-08 Folylpolyglutamate synthase OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN folC PE 3 SV 1
blastp_uniprot_sprot sp|Q54CY5|FOLC_DICDI 47 180 + 134 Gaps:23 23.80 626 28.19 4e-06 Putative folylpolyglutamate synthase OS Dictyostelium discoideum GN folC PE 3 SV 1
blastp_uniprot_sprot sp|Q9UTD0|FOLD_SCHPO 49 159 + 111 Gaps:21 29.74 417 31.45 4e-06 Probable dihydrofolate synthetase OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN fol3 PE 3 SV 1
rpsblast_cdd gnl|CDD|178501 49 218 + 170 Gaps:21 37.45 510 63.35 3e-74 PLN02913 PLN02913 dihydrofolate synthetase.
rpsblast_cdd gnl|CDD|30633 49 180 + 132 Gaps:23 33.96 427 31.72 4e-17 COG0285 FolC Folylpolyglutamate synthase [Coenzyme metabolism].
rpsblast_cdd gnl|CDD|200112 49 180 + 132 Gaps:23 35.93 398 35.66 2e-16 TIGR01499 folC folylpolyglutamate synthase/dihydrofolate synthase. This model represents the FolC family of folate pathway proteins. Most examples are bifunctional active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically) the model is treated as subfamily not equivalog.
rpsblast_cdd gnl|CDD|182774 53 164 + 112 Gaps:16 23.08 416 39.58 9e-07 PRK10846 PRK10846 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase Provisional.
rpsblast_kog gnl|CDD|37736 47 179 + 133 Gaps:30 30.04 496 28.86 1e-18 KOG2525 KOG2525 KOG2525 Folylpolyglutamate synthase [Coenzyme transport and metabolism].

7 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 54 221 168 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 49 185 137 PTHR11136 "KEGG:00790+6.3.2.17","MetaCyc:PWY-2161","UniPathway:UPA00850";signature_desc=FOLYLPOLYGLUTAMATE SYNTHASE-RELATED none IPR001645
Gene3D 47 187 141 G3DSA:3.40.1190.10 "UniPathway:UPA00219" none IPR013221
SUPERFAMILY 49 183 135 SSF53623 "UniPathway:UPA00219" none IPR013221
Phobius 36 53 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 35 35 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 49 185 137 PTHR11136:SF0 none none none

1 Localization

Analysis Start End Length
TMHMM 36 55 19

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL4_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,45 0 27,45 lod 4,5 10,6
Bourran_2000_2002_QTL7_Delta.F Qrob_Chr09 9 v_5944_442 s_1BA1PC_866 23.51 10,96 35,74 lod 4.1466 0.041
Bourran2_2004_QTL14_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,83 10,33 22,33 lod 3,8 9
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nSecLBD_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 35,81 34,88 37,45 lod 4.4 10.4
Bourran_2000_2002_QTL4_Delta.F Qrob_Chr09 9 s_1C1GRV_1289 v_12080_1202 2.56 0 13,73 lod 7.4808 0.051

0 Targeting