Protein : Qrob_P0600570.2 Q. robur
Protein Identifier  ? Qrob_P0600570.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K15305 - vacuole morphology and inheritance protein 14 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 670  
Kegg Orthology  K15305
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0043550 regulation of lipid kinase activity Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.
GO:0070772 PAS complex A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.

23 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa002039mg 1 667 + 667 Gaps:26 95.59 725 88.60 0.0 hypothetical protein
blastp_kegg lcl|pxb:103943077 1 664 + 664 Gaps:25 94.77 727 87.95 0.0 protein VAC14 homolog
blastp_kegg lcl|pmum:103321448 10 667 + 658 Gaps:26 95.00 720 88.60 0.0 protein VAC14 homolog
blastp_kegg lcl|gmx:100789602 1 667 + 667 Gaps:27 95.84 722 86.42 0.0 protein VAC14 homolog
blastp_kegg lcl|mdm:103444574 1 656 + 656 Gaps:25 93.67 727 87.67 0.0 protein VAC14 homolog
blastp_kegg lcl|cic:CICLE_v10014409mg 1 658 + 658 Gaps:26 94.34 725 87.28 0.0 hypothetical protein
blastp_kegg lcl|rcu:RCOM_0598020 1 668 + 668 Gaps:28 95.60 728 87.36 0.0 hypothetical protein
blastp_kegg lcl|cit:102628881 1 658 + 658 Gaps:27 94.35 726 87.15 0.0 protein VAC14 homolog
blastp_kegg lcl|mdm:103451543 1 664 + 664 Gaps:28 94.92 729 86.42 0.0 protein VAC14 homolog
blastp_kegg lcl|vvi:100243898 3 663 + 661 Gaps:28 94.50 727 86.17 0.0 protein VAC14 homolog-like
blastp_uniprot_sprot sp|Q9ZU97|VAC14_ARATH 1 654 + 654 Gaps:29 90.85 743 80.59 0.0 Protein VAC14 homolog OS Arabidopsis thaliana GN VAC14 PE 2 SV 2
blastp_uniprot_sprot sp|Q68F38|VAC14_XENLA 5 647 + 643 Gaps:155 96.68 782 39.81 6e-162 Protein VAC14 homolog OS Xenopus laevis GN vac14 PE 2 SV 1
blastp_uniprot_sprot sp|Q66L58|VAC14_DANRE 5 647 + 643 Gaps:145 96.76 771 39.28 9e-160 Protein VAC14 homolog OS Danio rerio GN vac14 PE 2 SV 1
blastp_uniprot_sprot sp|Q5ZIW5|VAC14_CHICK 5 647 + 643 Gaps:153 96.67 780 38.59 4e-159 Protein VAC14 homolog OS Gallus gallus GN VAC14 PE 2 SV 1
blastp_uniprot_sprot sp|Q08AM6|VAC14_HUMAN 11 647 + 637 Gaps:159 95.91 782 38.80 3e-156 Protein VAC14 homolog OS Homo sapiens GN VAC14 PE 1 SV 1
blastp_uniprot_sprot sp|A2VE70|VAC14_BOVIN 11 647 + 637 Gaps:160 95.91 783 39.55 2e-155 Protein VAC14 homolog OS Bos taurus GN VAC14 PE 2 SV 1
blastp_uniprot_sprot sp|Q80WQ2|VAC14_MOUSE 10 647 + 638 Gaps:163 96.04 782 39.15 9e-155 Protein VAC14 homolog OS Mus musculus GN Vac14 PE 1 SV 1
blastp_uniprot_sprot sp|Q80W92|VAC14_RAT 10 647 + 638 Gaps:164 96.04 783 38.96 6e-154 Protein VAC14 homolog OS Rattus norvegicus GN Vac14 PE 1 SV 1
blastp_uniprot_sprot sp|P87145|VAC14_SCHPO 12 604 + 593 Gaps:139 89.27 811 34.25 8e-123 Protein VAC14 homolog OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN SPBC25H2.03 PE 3 SV 1
blastp_uniprot_sprot sp|Q06708|VAC14_YEAST 11 601 + 591 Gaps:78 74.66 880 34.09 1e-58 Vacuole morphology and inheritance protein 14 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN VAC14 PE 1 SV 1
rpsblast_cdd gnl|CDD|204775 427 586 + 160 Gaps:23 100.00 181 54.14 2e-61 pfam11916 Vac14_Fig4_bd Vacuolar protein 14 C-terminal Fig4p binding. Vac14 is a scaffold for the Fab1 kinase complex a complex that allows for the dynamic interconversion of PI3P and PI(3 5)P2p (phosphoinositide phosphate (PIP) lipids that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p lipid phosphatase Fig4p the Fab1p activator Vac7p the Fab1p inhibitor Atg18p and Vac14p a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
rpsblast_cdd gnl|CDD|193231 65 161 + 97 none 100.00 97 64.95 2e-44 pfam12755 Vac14_Fab1_bd Vacuolar 14 Fab1-binding region. Vac14 is a scaffold for the Fab1 kinase complex a complex that allows for the dynamic interconversion of PI3P and PI(3 5)P2p (phosphoinositide phosphate (PIP) lipids that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p lipid phosphatase Fig4p the Fab1p activator Vac7p the Fab1p inhibitor Atg18p and Vac14p a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
rpsblast_kog gnl|CDD|35433 8 664 + 657 Gaps:50 98.52 675 49.77 0.0 KOG0212 KOG0212 KOG0212 Uncharacterized conserved protein [Function unknown].

8 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 1 659 659 PTHR16023 none none IPR026825
ProSiteProfiles 92 127 36 PS50077 none HEAT repeat profile. IPR021133
Pfam 65 161 97 PF12755 none Vacuolar 14 Fab1-binding region none
SUPERFAMILY 4 578 575 SSF48371 none none IPR016024
Gene3D 20 300 281 G3DSA:1.25.10.10 none none IPR011989
Gene3D 301 475 175 G3DSA:1.25.10.10 none none IPR011989
Pfam 427 570 144 PF11916 none Vacuolar protein 14 C-terminal Fig4p binding IPR021841
PANTHER 1 659 659 PTHR16023:SF0 none none none

0 Localization

5 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran_2000_2002_QTL6_Delta.F Qrob_Chr03 3 s_2HYXJ2_207 s_1AUAXK_317 29.12 6,3 45,37 lod 3.1666 0.026
Bourran2_2014_nLBD_3P Qrob_Chr03 3 s_1ET7H8_604 s_1BYNB5_834 23,73 0 46,72 lod 1,7573 3,8
PM_1999_QTL14_peak_Bud_burst_3P Qrob_Chr03 3 s_2F0SI1_756 v_6056_735 11,78 3,78 50,78 lod 2,5 4,5
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_rEpiBC*_3P Qrob_Chr03 3 s_1A3B3X_1163 s_1DKGMO_450 23,04 4,92 41,12 lod 2,5668 7

0 Targeting