Protein : Qrob_P0539130.2 Q. robur
Protein Identifier  ? Qrob_P0539130.2 Organism . Name  Quercus robur
Score  45.1 Score Type  egn
Protein Description  (M=1) 2.1.1.45 - Thymidylate synthase. Code Enzyme  EC:1.5.1.3, EC:2.1.1.45
Gene Prediction Quality  validated Protein length 

Sequence

Length: 506  
Kegg Orthology  K13998
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0 Synonyms

7 GO Terms

Identifier Name Description
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
GO:0004146 dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid.
GO:0004799 thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.
GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).

42 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100255872 1 505 + 505 Gaps:22 90.86 580 77.99 0.0 bifunctional dihydrofolate reductase-thymidylate synthase-like
blastp_kegg lcl|pxb:103967122 1 505 + 505 Gaps:23 94.27 558 76.81 0.0 bifunctional dihydrofolate reductase-thymidylate synthase-like
blastp_kegg lcl|mdm:103440375 1 505 + 505 Gaps:23 100.00 526 76.81 0.0 bifunctional dihydrofolate reductase-thymidylate synthase-like
blastp_kegg lcl|pmum:103335682 1 505 + 505 Gaps:23 99.25 530 77.00 0.0 bifunctional dihydrofolate reductase-thymidylate synthase-like
blastp_kegg lcl|vvi:100267529 1 505 + 505 Gaps:19 100.00 524 76.15 0.0 bifunctional dihydrofolate reductase-thymidylate synthase-like
blastp_kegg lcl|pper:PRUPE_ppa004093mg 1 505 + 505 Gaps:23 99.25 530 76.43 0.0 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10028191mg 1 505 + 505 Gaps:22 100.00 527 74.00 0.0 hypothetical protein
blastp_kegg lcl|mdm:103448418 1 505 + 505 Gaps:23 99.25 530 74.90 0.0 bifunctional dihydrofolate reductase-thymidylate synthase-like
blastp_kegg lcl|tcc:TCM_006844 1 505 + 505 Gaps:24 100.00 529 74.48 0.0 Thymidylate synthase 1 isoform 1
blastp_kegg lcl|cit:102610005 1 505 + 505 Gaps:22 100.00 527 73.81 0.0 bifunctional dihydrofolate reductase-thymidylate synthase-like
blastp_pdb 3iro_D 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3iro_C 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3iro_B 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3iro_A 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3irn_D 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3irn_C 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3irn_B 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3irn_A 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3irm_D 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_pdb 3irm_C 22 505 + 484 Gaps:53 96.16 521 46.71 1e-148 mol:protein length:521 Bifunctional dihydrofolate reductase-thymidyl
blastp_uniprot_sprot sp|O81395|DRTS_MAIZE 9 505 + 497 Gaps:24 99.23 521 73.31 0.0 Bifunctional dihydrofolate reductase-thymidylate synthase OS Zea mays GN DRTS PE 2 SV 1
blastp_uniprot_sprot sp|P51820|DRTS_SOYBN 10 505 + 496 Gaps:22 97.74 530 73.36 0.0 Bifunctional dihydrofolate reductase-thymidylate synthase OS Glycine max PE 1 SV 1
blastp_uniprot_sprot sp|Q05763|DRTS2_ARATH 11 505 + 495 Gaps:18 90.80 565 72.32 0.0 Bifunctional dihydrofolate reductase-thymidylate synthase 2 OS Arabidopsis thaliana GN THY-2 PE 2 SV 2
blastp_uniprot_sprot sp|P45350|DRTS_DAUCA 1 505 + 505 Gaps:23 100.00 528 71.59 0.0 Bifunctional dihydrofolate reductase-thymidylate synthase OS Daucus carota PE 2 SV 1
blastp_uniprot_sprot sp|Q05762|DRTS1_ARATH 16 505 + 490 Gaps:16 97.50 519 71.54 0.0 Bifunctional dihydrofolate reductase-thymidylate synthase 1 OS Arabidopsis thaliana GN THY-1 PE 2 SV 2
blastp_uniprot_sprot sp|Q2QRX6|DRTS_ORYSJ 34 505 + 472 Gaps:22 100.00 494 72.06 0.0 Putative bifunctional dihydrofolate reductase-thymidylate synthase OS Oryza sativa subsp. japonica GN Os12g0446900 PE 3 SV 2
blastp_uniprot_sprot sp|Q27828|DRTS_PARTE 22 505 + 484 Gaps:56 99.13 462 49.78 9e-155 Bifunctional dihydrofolate reductase-thymidylate synthase OS Paramecium tetraurelia GN GSPATT00019973001 PE 3 SV 1
blastp_uniprot_sprot sp|Q27793|DRTS_TRYCR 22 505 + 484 Gaps:53 96.16 521 46.71 4e-148 Bifunctional dihydrofolate reductase-thymidylate synthase OS Trypanosoma cruzi PE 1 SV 2
blastp_uniprot_sprot sp|Q27783|DRTS_TRYBB 22 505 + 484 Gaps:63 95.07 527 46.51 4e-147 Bifunctional dihydrofolate reductase-thymidylate synthase OS Trypanosoma brucei brucei PE 1 SV 1
blastp_uniprot_sprot sp|P16126|DRTS_LEIAM 5 505 + 501 Gaps:68 98.27 520 44.81 4e-144 Bifunctional dihydrofolate reductase-thymidylate synthase OS Leishmania amazonensis PE 3 SV 1

19 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSiteProfiles 23 200 178 PS51330 "KEGG:00670+1.5.1.3","KEGG:00790+1.5.1.3","MetaCyc:PWY-3841","MetaCyc:PWY-6614","UniPathway:UPA00077" Dihydrofolate reductase (DHFR) domain profile. IPR001796
SUPERFAMILY 217 505 289 SSF55831 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" none IPR023451
Pfam 237 505 269 PF00303 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase IPR000398
Pfam 25 200 176 PF00186 "KEGG:00670+1.5.1.3","KEGG:00790+1.5.1.3","MetaCyc:PWY-3841","MetaCyc:PWY-6614","UniPathway:UPA00077" Dihydrofolate reductase IPR001796
PRINTS 356 375 20 PR00108 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase family signature IPR000398
PRINTS 400 426 27 PR00108 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase family signature IPR000398
PRINTS 382 397 16 PR00108 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase family signature IPR000398
PRINTS 278 299 22 PR00108 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase family signature IPR000398
PRINTS 438 455 18 PR00108 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase family signature IPR000398
SUPERFAMILY 21 200 180 SSF53597 none none IPR024072
PIRSF 10 505 496 PIRSF000389 "KEGG:00240+2.1.1.45","KEGG:00670+1.5.1.3+2.1.1.45","KEGG:00790+1.5.1.3","MetaCyc:PWY-3841","MetaCyc:PWY-6614","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00077" none IPR012262
PANTHER 15 505 491 PTHR11549 none none none
ProSitePatterns 367 395 29 PS00091 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase active site. IPR020940
Gene3D 21 200 180 G3DSA:3.40.430.10 none none IPR024072
Hamap 237 505 269 MF_00008 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" Thymidylate synthase [thyA]. IPR000398
PANTHER 15 505 491 PTHR11549:SF2 none none none
TIGRFAM 318 505 188 TIGR03284 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" thym_sym: thymidylate synthase IPR000398
Gene3D 229 505 277 G3DSA:3.30.572.10 "KEGG:00240+2.1.1.45","KEGG:00670+2.1.1.45","MetaCyc:PWY-3841","MetaCyc:PWY-7184","MetaCyc:PWY-7187","MetaCyc:PWY-7198","MetaCyc:PWY-7199","MetaCyc:PWY-7210","UniPathway:UPA00575" none IPR023451
ProSitePatterns 35 57 23 PS00075 "KEGG:00670+1.5.1.3","KEGG:00790+1.5.1.3","MetaCyc:PWY-3841","MetaCyc:PWY-6614","UniPathway:UPA00077" Dihydrofolate reductase (DHFR) domain signature. IPR017925

0 Localization

12 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 24,87 24,63 26,18 lod 3.8 7
Bourran1_2003_QTL1_peak_Bud_burst_3P Qrob_Chr02 2 s_1AR8KI_1183 s_1B0QB1_473 22 6 41 lod 4,2 11,5
Bourran1_2004_QTL3_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 46 lod 2,9 6,4
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5
Champenoux_2015_nEpis_A4 Qrob_Chr02 2 s_1BAGIZ_823 s_1BN4CB_644 23,06 23,06 23,06 lod 4.9 11
Champenoux_2015_nP_A4 Qrob_Chr02 2 s_1BN4CB_644 v_508_128 23,76 23,06 24,51 lod 2.8 6.2
Champenoux_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 25,35 24,63 26,18 lod 4.0 8.7
Champenoux_2015_nSecLBD_A4 Qrob_Chr02 2 s_1AN4ZM_1665 v_8587_238 18,52 18,89 18,27 lod 3.2 7.4

0 Targeting