Protein : Qrob_P0505040.2 Q. robur
Protein Identifier  ? Qrob_P0505040.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) 1.13.11.5 - Homogentisate 1,2-dioxygenase. Code Enzyme  EC:1.13.11.5
Gene Prediction Quality  validated Protein length 

Sequence

Length: 457  
Kegg Orthology  K00451
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
GO:0004411 homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
GO:0006570 tyrosine metabolic process The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

28 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cit:102613255 1 451 + 451 Gaps:1 94.14 478 84.00 0.0 homogentisate 1 2-dioxygenase-like
blastp_kegg lcl|sot:102579798 11 456 + 446 Gaps:1 90.45 492 84.72 0.0 homogentisate 1 2-dioxygenase-like
blastp_kegg lcl|sly:543605 11 456 + 446 Gaps:1 92.71 480 84.04 0.0 HGO homogentisate 1 2-dioxygenase
blastp_kegg lcl|pper:PRUPE_ppa005219mg 11 456 + 446 Gaps:1 94.28 472 83.82 0.0 hypothetical protein
blastp_kegg lcl|pxb:103928802 11 456 + 446 Gaps:1 94.28 472 82.92 0.0 homogentisate 1 2-dioxygenase
blastp_kegg lcl|tcc:TCM_031685 10 443 + 434 Gaps:1 96.01 451 86.37 0.0 Homogentisate 1 2-dioxygenase isoform 1
blastp_kegg lcl|pmum:103326022 11 456 + 446 Gaps:1 94.28 472 83.15 0.0 homogentisate 1 2-dioxygenase
blastp_kegg lcl|cam:101499118 1 456 + 456 Gaps:3 99.56 455 82.78 0.0 homogentisate 1 2-dioxygenase-like
blastp_kegg lcl|rcu:RCOM_1743950 2 454 + 453 Gaps:1 98.91 457 81.42 0.0 homogentisate 1 2-dioxygenase putative (EC:1.13.11.5)
blastp_kegg lcl|vvi:100264043 2 456 + 455 Gaps:1 98.06 463 81.50 0.0 homogentisate 1 2-dioxygenase-like
blastp_pdb 1eyb_A 2 443 + 442 Gaps:16 93.84 471 57.01 1e-174 mol:protein length:471 HOMOGENTISATE 1 2-DIOXYGENASE
blastp_pdb 1ey2_A 2 443 + 442 Gaps:16 93.84 471 57.01 1e-174 mol:protein length:471 HOMOGENTISATE 1 2-DIOXYGENASE
blastp_uniprot_sprot sp|Q9ZRA2|HGD_ARATH 14 453 + 440 Gaps:1 95.23 461 79.04 0.0 Homogentisate 1 2-dioxygenase OS Arabidopsis thaliana GN HGO PE 2 SV 2
blastp_uniprot_sprot sp|Q5VRH4|HGD_ORYSJ 2 443 + 442 Gaps:4 94.89 470 74.66 0.0 Homogentisate 1 2-dioxygenase OS Oryza sativa subsp. japonica GN HGO PE 2 SV 1
blastp_uniprot_sprot sp|Q54QI4|HGD_DICDI 6 441 + 436 Gaps:12 99.07 432 61.68 1e-180 Homogentisate 1 2-dioxygenase OS Dictyostelium discoideum GN hgd PE 2 SV 1
blastp_uniprot_sprot sp|O09173|HGD_MOUSE 11 443 + 433 Gaps:16 97.30 445 58.66 2e-176 Homogentisate 1 2-dioxygenase OS Mus musculus GN Hgd PE 1 SV 2
blastp_uniprot_sprot sp|Q39J54|HGD_BURS3 14 445 + 432 Gaps:4 96.85 444 57.44 4e-176 Homogentisate 1 2-dioxygenase OS Burkholderia sp. (strain 383) GN hmgA PE 3 SV 1
blastp_uniprot_sprot sp|A0K4Z6|HGD_BURCH 14 445 + 432 Gaps:4 96.85 444 57.91 1e-175 Homogentisate 1 2-dioxygenase OS Burkholderia cenocepacia (strain HI2424) GN hmgA PE 3 SV 1
blastp_uniprot_sprot sp|Q1BYQ6|HGD_BURCA 14 445 + 432 Gaps:4 96.85 444 57.91 1e-175 Homogentisate 1 2-dioxygenase OS Burkholderia cenocepacia (strain AU 1054) GN hmgA PE 3 SV 1
blastp_uniprot_sprot sp|B1YTZ1|HGD_BURA4 14 445 + 432 Gaps:4 96.85 444 57.67 9e-175 Homogentisate 1 2-dioxygenase OS Burkholderia ambifaria (strain MC40-6) GN hmgA PE 3 SV 1
blastp_uniprot_sprot sp|A9AFM6|HGD_BURM1 14 445 + 432 Gaps:4 96.85 444 57.67 1e-174 Homogentisate 1 2-dioxygenase OS Burkholderia multivorans (strain ATCC 17616 / 249) GN hmgA PE 3 SV 1
blastp_uniprot_sprot sp|B1JWJ3|HGD_BURCC 14 445 + 432 Gaps:4 96.85 444 57.67 4e-174 Homogentisate 1 2-dioxygenase OS Burkholderia cenocepacia (strain MC0-3) GN hmgA PE 3 SV 1
rpsblast_cdd gnl|CDD|178264 14 448 + 435 none 100.00 435 80.23 0.0 PLN02658 PLN02658 homogentisate 1 2-dioxygenase.
rpsblast_cdd gnl|CDD|180028 1 445 + 445 Gaps:9 99.54 438 60.55 0.0 PRK05341 PRK05341 homogentisate 1 2-dioxygenase Provisional.
rpsblast_cdd gnl|CDD|202933 13 442 + 430 Gaps:10 100.00 422 64.69 0.0 pfam04209 HgmA homogentisate 1 2-dioxygenase. Homogentisate dioxygenase cleaves the aromatic ring during the metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria. The structure of homogentisate dioxygenase shows that the enzyme forms a hexamer arrangement comprised of a dimer of trimers. The active site iron ion is coordinated near the interface between the trimers.
rpsblast_cdd gnl|CDD|200065 11 442 + 432 Gaps:9 100.00 429 61.54 0.0 TIGR01015 hmgA homogentisate 1 2-dioxygenase. Missing in human disease alkaptonuria.
rpsblast_cdd gnl|CDD|33311 10 438 + 429 Gaps:8 98.59 427 57.01 1e-135 COG3508 HmgA Homogentisate 1 2-dioxygenase [Secondary metabolites biosynthesis transport and catabolism].
rpsblast_kog gnl|CDD|36631 7 443 + 437 Gaps:8 97.53 446 68.74 0.0 KOG1417 KOG1417 KOG1417 Homogentisate 1 2-dioxygenase [Amino acid transport and metabolism].

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 2 452 451 PTHR11056 "KEGG:00350+1.13.11.5","KEGG:00643+1.13.11.5","UniPathway:UPA00139";signature_desc=HOMOGENTISATE 1,2-DIOXYGENASE none IPR005708
Pfam 13 442 430 PF04209 "KEGG:00350+1.13.11.5","KEGG:00643+1.13.11.5","UniPathway:UPA00139" homogentisate 1,2-dioxygenase IPR005708
Gene3D 293 412 120 G3DSA:2.60.120.10 none none IPR014710
Gene3D 206 231 26 G3DSA:2.60.120.10 none none IPR014710
TIGRFAM 12 442 431 TIGR01015 "KEGG:00350+1.13.11.5","KEGG:00643+1.13.11.5","UniPathway:UPA00139" hmgA: homogentisate 1,2-dioxygenase IPR005708
SUPERFAMILY 12 444 433 SSF51182 none none IPR011051

0 Localization

16 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran_2000_2002_QTL3_Delta.F Qrob_Chr08 8 s_1A3EF7_1406 s_1AIWYC_607 30.17 21,01 40,21 lod 6.8553 0.055
Bourran2_2014_aSeqBC_A4 Qrob_Chr08 8 v_15999_278 v_AP13YL15_395 32,52 4,22 57,22 lod 2,7561 6,7
Bourran2_2014_nFork*_A4 Qrob_Chr08 8 PIE175 s_1CD7GJ_1398 31,22 5,24 57,24 lod 2,6724 6,8
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Bourran2_2014_nPriLBD_A4 Qrob_Chr08 8 PIE175 v_9164_159 31,85 15,39 48,29 lod 2,8308 6,8
Bourran2_2015_rEpiBC_3P Qrob_Chr08 8 s_A9TNV_543 v_11837_70 9,93 9,83 11,15 lod 3.3 7.3
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL3_d13Cf Qrob_Chr08 8 v_5216_549 v_11625_20 37.08 12,26 54,9 lod 6.5888 0.04
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting