Protein : Qrob_P0311250.2 Q. robur
Protein Identifier  ? Qrob_P0311250.2 Organism . Name  Quercus robur
Score  3.1 Score Type  egn
Protein Description  (M=11) KOG1052//KOG1053//KOG1054//KOG1055//KOG1056//KOG4440 - Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated NMDA-type ion channel receptor subunit GRIN2A and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated AMPA-type ion channel receptor subunit GluR2 and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // GABA-B ion channel receptor subunit GABABR1 and related subunits G-protein coupled receptor superfamily [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits G-protein coupled receptor superfamily [Inorganic ion transport and metabolism Signal transduction mechanisms]. // NMDA selective glutamate-gated ion channel receptor subunit GRIN1 [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. Gene Prediction Quality  validated
Protein length 

Sequence

Length: 956  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0004970 ionotropic glutamate receptor activity Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.

40 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_029764 6 930 + 925 Gaps:49 80.47 1111 60.40 0.0 Glutamate-gated kainate-type ion channel receptor subunit GluR5 putative
blastp_kegg lcl|pmum:103324853 1 916 + 916 Gaps:55 95.74 916 58.04 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|pop:POPTR_0004s05180g 16 948 + 933 Gaps:69 95.17 931 57.00 0.0 POPTRDRAFT_817827 hypothetical protein
blastp_kegg lcl|gmx:100818619 12 955 + 944 Gaps:67 95.74 939 55.17 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|pvu:PHAVU_006G179300g 16 909 + 894 Gaps:53 91.61 942 55.04 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_029763 3 930 + 928 Gaps:62 97.50 919 56.36 0.0 Glutamate-gated kainate-type ion channel receptor subunit GluR5 putative
blastp_kegg lcl|cam:101492454 13 914 + 902 Gaps:50 95.91 905 55.65 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|rcu:RCOM_1012900 62 882 + 821 Gaps:48 93.12 843 59.36 0.0 glutamate receptor 2 plant putative
blastp_kegg lcl|mtr:MTR_2g015270 9 913 + 905 Gaps:93 96.68 1083 53.01 0.0 Glutamate receptor 2.7
blastp_kegg lcl|gmx:100780320 1 925 + 925 Gaps:61 98.33 899 53.62 0.0 glutamate receptor 2.7-like
blastp_pdb 3kg2_D 468 883 + 416 Gaps:112 51.03 823 24.76 2e-15 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_C 468 883 + 416 Gaps:112 51.03 823 24.76 2e-15 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_B 468 883 + 416 Gaps:112 51.03 823 24.76 2e-15 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_A 468 883 + 416 Gaps:112 51.03 823 24.76 2e-15 mol:protein length:823 Glutamate receptor 2
blastp_uniprot_sprot sp|Q8LGN0|GLR27_ARATH 28 931 + 904 Gaps:101 92.96 952 33.56 2e-135 Glutamate receptor 2.7 OS Arabidopsis thaliana GN GLR2.7 PE 2 SV 3
blastp_uniprot_sprot sp|Q9LFN8|GLR26_ARATH 14 888 + 875 Gaps:109 88.93 967 33.37 5e-133 Glutamate receptor 2.6 OS Arabidopsis thaliana GN GLR2.6 PE 2 SV 2
blastp_uniprot_sprot sp|Q9LFN5|GLR25_ARATH 66 878 + 813 Gaps:105 86.71 918 34.92 2e-131 Glutamate receptor 2.5 OS Arabidopsis thaliana GN GLR2.5 PE 2 SV 2
blastp_uniprot_sprot sp|O81776|GLR24_ARATH 14 848 + 835 Gaps:110 89.40 896 36.83 6e-131 Glutamate receptor 2.4 OS Arabidopsis thaliana GN GLR2.4 PE 2 SV 2
blastp_uniprot_sprot sp|Q93YT1|GLR32_ARATH 19 889 + 871 Gaps:112 94.85 912 33.76 1e-129 Glutamate receptor 3.2 OS Arabidopsis thaliana GN GLR3.2 PE 1 SV 2
blastp_uniprot_sprot sp|Q84W41|GLR36_ARATH 16 874 + 859 Gaps:109 93.24 903 32.19 9e-127 Glutamate receptor 3.6 OS Arabidopsis thaliana GN GLR3.6 PE 2 SV 1
blastp_uniprot_sprot sp|O81078|GLR29_ARATH 32 910 + 879 Gaps:102 89.89 940 34.79 1e-126 Glutamate receptor 2.9 OS Arabidopsis thaliana GN GLR2.9 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SW97|GLR35_ARATH 43 897 + 855 Gaps:109 90.03 953 33.92 4e-126 Glutamate receptor 3.5 OS Arabidopsis thaliana GN GLR3.5 PE 2 SV 2
blastp_uniprot_sprot sp|O04660|GLR21_ARATH 14 872 + 859 Gaps:113 93.23 901 33.21 5e-125 Glutamate receptor 2.1 OS Arabidopsis thaliana GN GLR2.1 PE 2 SV 2
blastp_uniprot_sprot sp|Q9C5V5|GLR28_ARATH 14 917 + 904 Gaps:108 91.45 947 33.14 1e-121 Glutamate receptor 2.8 OS Arabidopsis thaliana GN GLR2.8 PE 2 SV 2
rpsblast_cdd gnl|CDD|107361 43 416 + 374 Gaps:45 99.14 350 38.90 1e-76 cd06366 PBP1_GABAb_receptor Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and like glutamate and other transmitters acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha_i proteins and activation causes a decrease in calcium an increase in potassium membrane conductance and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release for example.
rpsblast_cdd gnl|CDD|189368 611 857 + 247 Gaps:20 98.88 268 30.19 1e-42 pfam00060 Lig_chan Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
rpsblast_cdd gnl|CDD|201592 61 399 + 339 Gaps:24 98.83 343 26.55 4e-34 pfam01094 ANF_receptor Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
rpsblast_cdd gnl|CDD|153138 42 318 + 277 Gaps:36 81.90 348 22.81 4e-30 cd06350 PBP1_GPCR_family_C_like Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further devided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP which is a bacterial periplasmic protein (PBP) as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA AMPA and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
rpsblast_cdd gnl|CDD|153137 43 302 + 260 Gaps:26 85.23 298 25.20 6e-28 cd06269 PBP1_glutamate_receptors_like Family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors. This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors all of which are structurally similar and related to the periplasmic-binding fold type I family. The family C GPCRs consist of metabotropic glutamate receptor (mGluR) receptors a calcium-sensing receptor (CaSR) gamma-aminobutyric receptors (GABAb) the promiscuous L-alpha-amino acid receptor GPR6A families of taste and pheromone receptors and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids ions and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors AMPA receptors and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B) the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E GC-F) and olfactory receptors (GC-D and GC-G).
rpsblast_cdd gnl|CDD|107261 43 345 + 303 Gaps:24 96.66 299 23.18 1e-21 cd04509 PBP1_ABC_transporter_GCPR_C_like Family C of G-protein coupled receptors and their close homologs the type I periplasmic-binding proteins of ATP-binding cassette transporter-like systems. This CD includes members of the family C of G-protein coupled receptors and their close homologs the type I periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor G-protein-coupled receptors metabotropic glutamate GABA-B calcium sensing phermone receptors and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels iGluR can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate) AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4- isoxazolepropionic acid) and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine-binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem a LIVBP-like domain that constitutes the N terminus - which is included in this CD - followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type II periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.

36 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SMART 455 827 373 SM00079 none Eukaryotic homologues of bacterial periplasmic substrate binding proteins. IPR001320
Pfam 555 823 269 PF00497 none Bacterial extracellular solute-binding proteins, family 3 none
Phobius 611 629 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 27 31 5 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
Gene3D 450 521 72 G3DSA:3.40.190.10 none none none
Gene3D 784 823 40 G3DSA:3.40.190.10 none none none
Gene3D 559 584 26 G3DSA:3.40.190.10 none none none
SUPERFAMILY 40 445 406 SSF53822 none none IPR028082
Gene3D 42 159 118 G3DSA:3.40.50.2300 none none none
Gene3D 321 384 64 G3DSA:3.40.50.2300 none none none
Phobius 554 571 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 608 856 249 PF00060 none Ligand-gated ion channel IPR001320
PANTHER 86 415 330 PTHR18966:SF6 none none none
Gene3D 160 316 157 G3DSA:3.40.50.2300 none none none
Phobius 1 13 13 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
Gene3D 599 735 137 G3DSA:1.10.287.70 none none none
Phobius 1 31 31 SIGNAL_PEPTIDE none Signal peptide region none
Phobius 660 670 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 14 26 13 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
Phobius 872 955 84 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 559 882 324 PTHR18966 none none none
PANTHER 86 415 330 PTHR18966 none none none
SUPERFAMILY 451 521 71 SSF53850 none none none
SUPERFAMILY 700 823 124 SSF53850 none none none
SUPERFAMILY 559 595 37 SSF53850 none none none
Phobius 630 640 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 690 848 159 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 572 610 39 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 671 689 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 32 553 522 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none

5 Localization

Analysis Start End Length
TMHMM 849 871 22
TMHMM 612 629 17
SignalP_EUK 1 31 30
TMHMM 5 27 22
TMHMM 672 694 22

1 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_rEpiBC_3P Qrob_Chr05 5 s_2GDU0O_517 s_1BT8O3_239 25,81 0 55,45 lod 2,2101 5,5

0 Targeting