Protein : Qrob_P0297350.2 Q. robur
Protein Identifier  ? Qrob_P0297350.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) KOG0747//KOG1429 - Putative NAD+-dependent epimerases [Carbohydrate transport and metabolism]. // dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase [Carbohydrate transport and metabolism Cell wall/membrane/envelope biogenesis]. Code Enzyme  EC:4.1.1.35
Gene Prediction Quality  validated Protein length 

Sequence

Length: 209  
Kegg Orthology  K08678
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0050662 coenzyme binding Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

41 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0001s24380g 1 169 + 169 Gaps:35 62.01 329 60.78 5e-68 POPTRDRAFT_706198 UDP-GLUCURONIC ACID DECARBOXYLASE family protein
blastp_kegg lcl|atr:s00092p00147500 15 182 + 168 Gaps:28 66.43 286 51.58 1e-48 AMTR_s00092p00147500 hypothetical protein
blastp_kegg lcl|pvu:PHAVU_011G065700g 1 169 + 169 none 34.50 342 95.76 5e-47 hypothetical protein
blastp_kegg lcl|vvi:100245048 1 169 + 169 none 34.10 346 98.31 5e-47 UDP-glucuronic acid decarboxylase 1-like
blastp_kegg lcl|gmx:100819843 1 169 + 169 none 34.50 342 96.61 5e-47 UDP-glucuronic acid decarboxylase 1-like
blastp_kegg lcl|gmx:100816443 1 169 + 169 none 34.50 342 96.61 6e-47 UDP-glucuronic acid decarboxylase 6-like
blastp_kegg lcl|tcc:TCM_041878 1 169 + 169 none 34.10 346 96.61 7e-47 UDP-XYL synthase 5 isoform 5
blastp_kegg lcl|mtr:MTR_2g096660 1 169 + 169 none 33.62 351 96.61 7e-47 UDP-glucuronic acid decarboxylase
blastp_kegg lcl|mus:103987002 1 169 + 169 none 34.10 346 95.76 7e-47 UDP-glucuronic acid decarboxylase 6-like
blastp_kegg lcl|tcc:TCM_042808 1 169 + 169 none 34.40 343 94.92 1e-46 UDP-XYL synthase 6
blastp_pdb 4ef7_B 89 167 + 79 none 23.44 337 64.56 6e-30 mol:protein length:337 UDP-glucuronic acid decarboxylase 1
blastp_pdb 4ef7_A 89 167 + 79 none 23.44 337 64.56 6e-30 mol:protein length:337 UDP-glucuronic acid decarboxylase 1
blastp_pdb 2b69_A 89 167 + 79 none 23.03 343 64.56 7e-30 mol:protein length:343 UDP-glucuronate decarboxylase 1
blastp_pdb 3slg_F 69 167 + 99 Gaps:18 28.76 372 33.64 2e-07 mol:protein length:372 PbgP3 protein
blastp_pdb 3slg_E 69 167 + 99 Gaps:18 28.76 372 33.64 2e-07 mol:protein length:372 PbgP3 protein
blastp_pdb 3slg_D 69 167 + 99 Gaps:18 28.76 372 33.64 2e-07 mol:protein length:372 PbgP3 protein
blastp_pdb 3slg_C 69 167 + 99 Gaps:18 28.76 372 33.64 2e-07 mol:protein length:372 PbgP3 protein
blastp_pdb 3slg_B 69 167 + 99 Gaps:18 28.76 372 33.64 2e-07 mol:protein length:372 PbgP3 protein
blastp_pdb 3slg_A 69 167 + 99 Gaps:18 28.76 372 33.64 2e-07 mol:protein length:372 PbgP3 protein
blastp_uniprot_sprot sp|Q9FIE8|UXS3_ARATH 1 169 + 169 none 34.50 342 94.07 9e-46 UDP-glucuronic acid decarboxylase 3 OS Arabidopsis thaliana GN UXS3 PE 1 SV 1
blastp_uniprot_sprot sp|Q9SN95|UXS5_ARATH 1 169 + 169 none 34.60 341 94.92 1e-45 UDP-glucuronic acid decarboxylase 5 OS Arabidopsis thaliana GN UXS5 PE 2 SV 1
blastp_uniprot_sprot sp|Q9ZV36|UXS6_ARATH 1 169 + 169 none 34.40 343 93.22 7e-45 UDP-glucuronic acid decarboxylase 6 OS Arabidopsis thaliana GN UXS6 PE 2 SV 1
blastp_uniprot_sprot sp|Q8S8T4|UXS4_ARATH 64 169 + 106 Gaps:2 24.38 443 59.26 2e-33 UDP-glucuronic acid decarboxylase 4 OS Arabidopsis thaliana GN UXS4 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LZI2|UXS2_ARATH 64 169 + 106 Gaps:2 24.27 445 59.26 3e-33 UDP-glucuronic acid decarboxylase 2 OS Arabidopsis thaliana GN UXS2 PE 1 SV 1
blastp_uniprot_sprot sp|Q8VZC0|UXS1_ARATH 6 169 + 164 none 25.52 435 66.67 2e-30 UDP-glucuronic acid decarboxylase 1 OS Arabidopsis thaliana GN UXS1 PE 2 SV 1
blastp_uniprot_sprot sp|Q8NBZ7|UXS1_HUMAN 89 167 + 79 none 18.81 420 64.56 3e-29 UDP-glucuronic acid decarboxylase 1 OS Homo sapiens GN UXS1 PE 1 SV 1
blastp_uniprot_sprot sp|Q5R885|UXS1_PONAB 89 167 + 79 none 18.81 420 64.56 3e-29 UDP-glucuronic acid decarboxylase 1 OS Pongo abelii GN UXS1 PE 2 SV 1
blastp_uniprot_sprot sp|Q91XL3|UXS1_MOUSE 89 167 + 79 none 18.81 420 64.56 3e-29 UDP-glucuronic acid decarboxylase 1 OS Mus musculus GN Uxs1 PE 2 SV 1
blastp_uniprot_sprot sp|Q5PQX0|UXS1_RAT 89 167 + 79 none 18.81 420 64.56 3e-29 UDP-glucuronic acid decarboxylase 1 OS Rattus norvegicus GN Uxs1 PE 1 SV 1
rpsblast_cdd gnl|CDD|187541 3 169 + 167 Gaps:1 38.36 305 66.67 3e-42 cd05230 UGD_SDR_e UDP-glucuronate decarboxylase (UGD) and related proteins extended (e) SDRs. UGD catalyzes the formation of UDP-xylose from UDP-glucuronate it is an extended-SDR and has the characteristic glycine-rich NAD-binding pattern TGXXGXXG and active site tetrad. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins and include isomerases epimerases oxidoreductases and lyases they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold an NAD(P)(H)-binding region and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range they catalyze a wide range of activities including the metabolism of steroids cofactors carbohydrates lipids aromatic compounds and amino acids and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151 human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys there is often an upstream Ser and/or an Asn contributing to the active site while substrate binding is in the C-terminal region which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys a water molecule stabilized by Asn and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 89 162 74 G3DSA:3.90.25.10 none none none
SUPERFAMILY 88 167 80 SSF51735 none none none
Gene3D 3 40 38 G3DSA:3.40.50.720 none none IPR016040
PANTHER 1 168 168 PTHR10366 none none none
Pfam 87 165 79 PF01370 none NAD dependent epimerase/dehydratase family IPR001509
PANTHER 1 168 168 PTHR10366:SF323 none none none

0 Localization

0 Qtllist

0 Targeting