Protein : Qrob_P0253480.2 Q. robur
Protein Identifier  ? Qrob_P0253480.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=9) PF01612 - 3'-5' exonuclease Gene Prediction Quality  validated
Protein length 

Sequence

Length: 199  
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

13 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cic:CICLE_v10003144mg 1 198 + 198 Gaps:18 98.96 192 45.79 8e-39 hypothetical protein
blastp_kegg lcl|pxb:103962352 1 198 + 198 Gaps:33 100.00 205 43.41 1e-30 uncharacterized LOC103962352
blastp_kegg lcl|cit:102608989 1 178 + 178 Gaps:18 76.92 221 44.12 2e-28 uncharacterized LOC102608989
blastp_kegg lcl|fve:101313333 4 198 + 195 Gaps:25 93.14 204 39.47 8e-24 uncharacterized protein LOC101313333
blastp_kegg lcl|pxb:103962349 87 198 + 112 Gaps:2 32.54 338 40.00 2e-18 transcription factor bHLH149-like
blastp_kegg lcl|bdi:100845179 15 195 + 181 Gaps:11 87.56 201 35.23 3e-17 Werner Syndrome-like exonuclease-like
blastp_kegg lcl|dosa:Os01t0660800-01 16 195 + 180 Gaps:8 90.45 199 30.56 3e-16 Os01g0660800 3'-5' exonuclease domain containing protein.
blastp_kegg lcl|osa:4327176 16 195 + 180 Gaps:8 90.45 199 30.56 3e-16 Os01g0660800
blastp_kegg lcl|zma:100283715 16 195 + 180 Gaps:9 89.50 200 30.73 2e-14 cl912_1 LOC100283715
blastp_kegg lcl|sita:101773693 2 198 + 197 Gaps:19 66.61 575 29.24 2e-14 uncharacterized LOC101773693
rpsblast_cdd gnl|CDD|176653 27 195 + 169 Gaps:18 97.06 170 28.48 2e-17 cd06141 WRN_exo DEDDy 3'-5' exonuclease domain of WRN and similar proteins. WRN is a unique RecQ DNA helicase exhibiting an exonuclease activity. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Mutations in the WRN gene cause Werner syndrome an autosomal recessive disorder associated with premature aging and increased susceptibility to cancer and type II diabetes. WRN interacts with key proteins involved in DNA replication recombination and repair. It is believed to maintain genomic stability and life span by participating in DNA processes. WRN is stimulated by Ku70/80 an important regulator of genomic stability.
rpsblast_cdd gnl|CDD|197748 42 198 + 157 Gaps:9 87.21 172 25.33 5e-10 smart00474 35EXOc 3'-5' exonuclease. 3\' -5' exonuclease proofreading domain present in DNA polymerase I Werner syndrome helicase RNase D and other enzymes.
rpsblast_cdd gnl|CDD|201888 42 198 + 157 Gaps:10 87.79 172 27.81 6e-08 pfam01612 DNA_pol_A_exo1 3'-5' exonuclease. This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes it catalyzes the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN) focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.

3 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 11 195 185 G3DSA:3.30.420.10 none none IPR012337
SUPERFAMILY 41 195 155 SSF53098 none none IPR012337
Pfam 42 198 157 PF01612 none 3'-5' exonuclease IPR002562

0 Localization

0 Qtllist

0 Targeting