Protein : Qrob_P0184010.2 Q. robur
Protein Identifier  ? Qrob_P0184010.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) K06171 - nicastrin Gene Prediction Quality  validated
Protein length 

Sequence

Length: 333  
Kegg Orthology  K06171
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0016485 protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

19 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa002463mg 1 332 + 332 Gaps:3 50.00 670 77.61 0.0 hypothetical protein
blastp_kegg lcl|fve:101308133 1 332 + 332 Gaps:1 38.72 860 75.98 7e-179 nicastrin-like
blastp_kegg lcl|cic:CICLE_v10000514mg 1 332 + 332 Gaps:1 50.92 654 72.97 1e-177 hypothetical protein
blastp_kegg lcl|tcc:TCM_043862 1 332 + 332 Gaps:3 49.70 666 75.53 1e-175 Zn-dependent exopeptidases superfamily protein isoform 1
blastp_kegg lcl|vvi:100241276 1 332 + 332 Gaps:1 49.63 671 73.57 2e-175 nicastrin-like
blastp_kegg lcl|gmx:100801506 1 332 + 332 Gaps:1 49.78 669 72.67 3e-174 nicastrin-like
blastp_kegg lcl|mdm:103432331 1 332 + 332 Gaps:2 66.27 504 76.05 4e-174 nicastrin-like
blastp_kegg lcl|pxb:103959888 1 332 + 332 Gaps:2 49.93 669 74.85 2e-172 nicastrin
blastp_kegg lcl|cit:102608581 1 332 + 332 Gaps:34 52.06 703 66.39 1e-170 nicastrin-like
blastp_kegg lcl|pop:POPTR_0004s08120g 1 332 + 332 Gaps:3 49.40 670 72.81 3e-168 POPTRDRAFT_1075823 nicastrin-related family protein
blastp_uniprot_sprot sp|Q8GUM5|NICA_ARATH 1 332 + 332 Gaps:2 49.41 676 66.47 1e-149 Nicastrin OS Arabidopsis thaliana GN At3g52640/At3g52650 PE 2 SV 1
blastp_uniprot_sprot sp|Q54JT7|NICA_DICDI 1 330 + 330 Gaps:57 48.41 659 25.71 5e-14 Nicastrin OS Dictyostelium discoideum GN ncstn PE 3 SV 2
blastp_uniprot_sprot sp|P57716|NICA_MOUSE 54 316 + 263 Gaps:58 37.99 708 30.11 1e-08 Nicastrin OS Mus musculus GN Ncstn PE 1 SV 3
blastp_uniprot_sprot sp|Q92542|NICA_HUMAN 47 316 + 270 Gaps:55 38.79 709 29.09 6e-08 Nicastrin OS Homo sapiens GN NCSTN PE 1 SV 2
blastp_uniprot_sprot sp|Q8CGU6|NICA_RAT 58 316 + 259 Gaps:62 37.43 708 29.06 9e-08 Nicastrin OS Rattus norvegicus GN Ncstn PE 1 SV 1
blastp_uniprot_sprot sp|Q9VC27|NICA_DROME 59 320 + 262 Gaps:67 37.27 695 26.25 5e-06 Nicastrin OS Drosophila melanogaster GN nct PE 1 SV 3
rpsblast_cdd gnl|CDD|114188 1 118 + 118 Gaps:17 56.83 227 45.74 4e-28 pfam05450 Nicastrin Nicastrin. Nicastrin and presenilin are two major components of the gamma-secretase complex which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch. Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin). A region featured in this family has a fold similar to human transferrin receptor (TfR) and a bacterial aminopeptidase. It is implicated in the pathogenesis of Alzheimer's disease.
rpsblast_cdd gnl|CDD|193502 2 115 + 114 Gaps:12 37.01 308 32.46 2e-13 cd03881 M28_Nicastrin M28 Zn-Peptidase Nicastrin a main component of gamma-secretase complex. Peptidase M28 family Nicastrin subfamily. Nicastrin is a main component of gamma-secretase complex. Its extracellular domain sequence resembles aminopeptidases but certain catalytic residues are not conserved. It is mainly localized to the endoplasmic reticulum and Golgi. It is highly glycosylated (Mr 120 kDa) and is essential for substrate recognition of the N-terminus of gamma-secretase substrates derived from APP and Notch. Nicastrin facilitates substrate cleavage by the catalytic presenilin subunit in the gamma-secretase complex. One conserved glutamate is especially important probably because this residue forms an ion pair with the amino terminus of the substrate. This substrate-binding domain is often called the DAP domain (named after DYIGS the amino acid stretch that modulates amyloid precursor protein (APP) processing and Peptidase homologous region). The sequence of the substrate N-terminus is apparently not critical for the interaction but a free amino group is. Thus nicastrin can be considered a kind of gatekeeper for the gamma-secretase complex: type I membrane proteins that have not shed their ectodomains cannot interact properly with nicastrin and do not gain access to the active site.
rpsblast_kog gnl|CDD|37868 1 332 + 332 Gaps:17 54.87 596 26.61 5e-69 KOG2657 KOG2657 KOG2657 Transmembrane glycoprotein nicastrin [Signal transduction mechanisms Posttranslational modification protein turnover chaperones].

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 2 327 326 PTHR21092:SF0 none none none
Phobius 326 332 7 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 302 325 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 1 118 118 PF05450 none Nicastrin IPR008710
Phobius 1 301 301 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 2 327 326 PTHR21092 none none IPR008710

1 Localization

Analysis Start End Length
TMHMM 303 325 22

0 Qtllist

0 Targeting