Protein : Qrob_P0183300.2 Q. robur
Protein Identifier  ? Qrob_P0183300.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=3) PTHR30231 - DNA POLYMERASE III SUBUNIT EPSILON Code Enzyme  EC:2.7.7.7
Gene Prediction Quality  validated Protein length 

Sequence

Length: 289  
Paste the following link
Lists
This Protein isn't in any lists. Upload a list.

Sequence Feature Displayer

Protein Sequence Displayer

J Browse Displayer

0 Synonyms

2 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0004527 exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.

22 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cic:CICLE_v10026247mg 10 288 + 279 Gaps:14 96.39 277 81.27 1e-157 hypothetical protein
blastp_kegg lcl|cit:102629602 10 288 + 279 Gaps:14 96.39 277 81.27 1e-157 uncharacterized LOC102629602
blastp_kegg lcl|pop:POPTR_0005s08090g 13 288 + 276 Gaps:13 96.34 273 77.95 3e-152 POPTRDRAFT_860490 hypothetical protein
blastp_kegg lcl|tcc:TCM_001169 1 288 + 288 Gaps:34 100.00 296 73.31 3e-151 DNA polymerase III polC-type isoform 1
blastp_kegg lcl|fve:101298332 13 288 + 276 Gaps:12 94.33 282 77.44 7e-151 DNA polymerase III PolC-type-like
blastp_kegg lcl|pper:PRUPE_ppa024531mg 5 288 + 284 Gaps:13 98.20 278 77.29 1e-150 hypothetical protein
blastp_kegg lcl|pxb:103959278 5 288 + 284 Gaps:12 98.21 279 74.82 4e-149 uncharacterized LOC103959278
blastp_kegg lcl|mdm:103422255 5 288 + 284 Gaps:12 98.21 279 74.82 8e-149 uncharacterized LOC103422255
blastp_kegg lcl|gmx:100791906 1 288 + 288 Gaps:14 100.00 276 78.26 9e-149 uncharacterized LOC100791906
blastp_kegg lcl|cam:101498761 13 288 + 276 Gaps:15 97.79 271 78.49 1e-148 uncharacterized LOC101498761
blastp_uniprot_sprot sp|Q8RA32|DPO3_THETN 12 178 + 167 Gaps:11 11.28 1401 27.85 6e-07 DNA polymerase III PolC-type OS Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) GN polC PE 3 SV 1
blastp_uniprot_sprot sp|Q8XJR3|DPO3_CLOPE 13 179 + 167 Gaps:11 10.90 1449 27.85 5e-06 DNA polymerase III PolC-type OS Clostridium perfringens (strain 13 / Type A) GN polC PE 3 SV 1
rpsblast_cdd gnl|CDD|197752 13 186 + 174 Gaps:11 100.00 169 26.04 2e-23 smart00479 EXOIII exonuclease domain in DNA-polymerase alpha and epsilon chain ribonuclease T and other exonucleases.
rpsblast_cdd gnl|CDD|176648 15 179 + 165 Gaps:8 100.00 159 30.82 1e-21 cd06127 DEDDh DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases part of the DnaQ-like (or DEDD) exonuclease superfamily catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III the main replicating enzyme in bacteria which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T Oligoribonuclease and RNA exonuclease (REX) among others.
rpsblast_cdd gnl|CDD|201510 15 178 + 164 Gaps:11 100.00 161 27.33 2e-19 pfam00929 RNase_T Exonuclease. This family includes a variety of exonuclease proteins such as ribonuclease T and the epsilon subunit of DNA polymerase III. .
rpsblast_cdd gnl|CDD|31188 11 224 + 214 Gaps:12 86.42 243 23.81 1e-16 COG0847 DnaQ DNA polymerase III epsilon subunit and related 3'-5' exonucleases [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|99836 14 181 + 168 Gaps:21 99.43 176 23.43 7e-13 cd06133 ERI-1_3'hExo_like DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1 human 3' exonuclease and similar proteins. This subfamily is composed of Caenorhabditis elegans ERI-1 human 3' exonuclease (3'hExo) Drosophila exonuclease snipper (snp) and similar proteins from eukaryotes and bacteria. These are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ERI-1 has been implicated in the degradation of small interfering RNAs (RNAi). 3'hExo participates in the degradation of histone mRNAs. Snp is a non-essential exonuclease that efficiently degrades structured RNA and DNA substrates as long as there is a minimum of 2 nucleotides in the 3' overhang to initiate degradation. Snp is not a functional homolog of either ERI-1 or 3'hExo.
rpsblast_cdd gnl|CDD|181157 15 178 + 164 Gaps:26 28.37 557 36.71 7e-13 PRK07883 PRK07883 hypothetical protein Validated.
rpsblast_cdd gnl|CDD|99834 14 172 + 159 Gaps:25 94.87 156 31.08 1e-10 cd06130 DNA_pol_III_epsilon_like an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III) a multisubunit polymerase which is the main DNA replicating enzyme in bacteria functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits three of which (alpha epsilon and theta) compose the catalytic core. The Pol III epsilon subunit encoded by the dnaQ gene is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.
rpsblast_cdd gnl|CDD|181223 15 127 + 113 Gaps:20 11.53 928 31.78 2e-10 PRK08074 PRK08074 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon Validated.
rpsblast_cdd gnl|CDD|179031 12 170 + 159 Gaps:22 10.51 1437 29.14 1e-09 PRK00448 polC DNA polymerase III PolC Validated.
rpsblast_cdd gnl|CDD|180377 50 179 + 130 Gaps:16 39.62 313 29.03 2e-09 PRK06063 PRK06063 DNA polymerase III subunit epsilon Provisional.

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 12 197 186 PTHR30231 none none none
Pfam 15 178 164 PF00929 none Exonuclease IPR013520
SMART 13 187 175 SM00479 none none IPR006055
Gene3D 12 182 171 G3DSA:3.30.420.10 none none IPR012337
SUPERFAMILY 13 184 172 SSF53098 none none IPR012337
PANTHER 12 197 186 PTHR30231:SF4 none none none

0 Localization

0 Qtllist

0 Targeting