Protein : Qrob_P0170580.2 Q. robur
Protein Identifier  ? Qrob_P0170580.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) PTHR14379 - LIMKAIN B (LKAP) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 532  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0005777 peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
GO:0010468 regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

14 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_007077 1 530 + 530 Gaps:9 99.81 528 80.08 0.0 Endonuclease or glycosyl hydrolase
blastp_kegg lcl|pop:POPTR_0004s14770g 1 531 + 531 Gaps:2 100.00 531 77.21 0.0 hypothetical protein
blastp_kegg lcl|gmx:100818186 1 531 + 531 Gaps:1 100.00 532 77.26 0.0 uncharacterized LOC100818186
blastp_kegg lcl|pmum:103335364 1 531 + 531 Gaps:2 100.00 531 78.91 0.0 uncharacterized LOC103335364
blastp_kegg lcl|pvu:PHAVU_003G027700g 1 531 + 531 Gaps:1 100.00 532 76.32 0.0 hypothetical protein
blastp_kegg lcl|pper:PRUPE_ppa004084mg 1 531 + 531 Gaps:2 100.00 531 77.78 0.0 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10028188mg 1 531 + 531 Gaps:6 100.00 527 76.09 0.0 hypothetical protein
blastp_kegg lcl|rcu:RCOM_0813110 1 531 + 531 Gaps:2 100.00 531 76.84 0.0 hypothetical protein
blastp_kegg lcl|gmx:100807418 1 531 + 531 Gaps:3 100.00 534 76.97 0.0 uncharacterized LOC100807418
blastp_kegg lcl|pop:POPTR_0009s10350g 1 531 + 531 Gaps:2 100.00 531 74.95 0.0 POPTRDRAFT_804270 hypothetical protein
rpsblast_cdd gnl|CDD|199896 46 193 + 148 Gaps:3 100.00 145 51.03 3e-50 cd10910 limkain_b1_N_like N-terminal LabA-like domain of limkain b1 and similar proteins. This eukaryotic subfamily of LabA-like domains contains the N-terminal domain of human limkain b1 a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. Limkain b1 contains multiple copies of LOTUS domains and a conserved RNA recognition motif its - and similar - domain architectures are shared by several members of this family and a function of these architectures in RNA binding or RNA metabolism has been suggested. The function of the N-terminal domain is unknown. LabA_like domains exhibit some similarity to the NYN domain a distant relative of the PIN-domain nucleases.
rpsblast_cdd gnl|CDD|202054 46 190 + 145 Gaps:14 98.58 141 34.53 6e-25 pfam01936 NYN NYN domain. These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1 YacP nucleases NYN domains). The NYN domain shares a common protein fold with two other previously characterized groups of nucleases namely the PIN (PilT N-terminal) and FLAP/5' --> 3' exonuclease superfamilies. These proteins share a common set of 4 acidic conserved residues that are predicted to constitute their active site. Based on the conservation of the acidic residues and structural elements Aravind and colleagues suggest that PIN and NYN domains are likely to bind only a single metal ion unlike the FLAP/5' --> 3' exonuclease superfamily which binds two metal ions. Based on conserved gene neighborhoods Aravind and colleagues infer that the bacterial members are likely to be components of the processome/degradsome that process tRNAs or ribosomal RNAs.
rpsblast_cdd gnl|CDD|199895 47 189 + 143 Gaps:16 100.00 151 27.81 1e-10 cd06167 LabA_like LabA_like proteins. A well conserved group of domains found in all three kingdoms of life with no defined function. LabA a member from Synechococcus elongatus PCC 7942 has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback regulation of the autokinase/autophosphatase KaiC a central component of the circadian clock system. In particular LabA seems necessary for KaiC-dependent repression of gene expression. Another member is the N-terminal domain of limkain b1 a human autoantigen associated with cytoplasmic vesicles. Curiously a gene labeled NicB from Pseudomonas putida S16 which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls in the LabA_like family. LabA_like domains exhibit some similarity to the NYN domain a distant relative of the PIN-domain nucleases.
rpsblast_cdd gnl|CDD|193585 312 519 + 208 none 100.00 70 50.00 2e-10 cd08824 LOTUS LOTUS is an uncharacterized small globular domain found in Limkain b1 Oskar and Tudor-containing proteins 5 and 7. LOTUS is an uncharacterized small globular domain found in Limkain b1 Oskar and Tudor-containing proteins 5 and 7. The LOTUS containing proteins are germline-specific and are found in the nuage/polar granules of germ cells. Tudor-containing protein 5 and 7 belong to the evolutionary conserved Tudor domain-containing protein (TDRD) family involved in germ cell development. In mice TDRD5 and TDRD7 are components of the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs) which are cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. Oskar protein is a critical component of the pole plasm in the Drosophila oocyte which is required for germ cell formation. Limkain b1 is a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. Limkain b1 contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be characterized. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.

7 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 42 184 143 G3DSA:3.40.50.1010 none none IPR029060
Pfam 457 520 64 PF12872 none OST-HTH/LOTUS domain IPR025605
Pfam 311 379 69 PF12872 none OST-HTH/LOTUS domain IPR025605
ProSiteProfiles 311 383 73 PS51644 none OST-type HTH domain profile. IPR025605
Pfam 46 185 140 PF01936 none NYN domain IPR021139
PANTHER 41 526 486 PTHR14379 none none IPR024768
ProSiteProfiles 456 530 75 PS51644 none OST-type HTH domain profile. IPR025605

0 Localization

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2002_QTL16_peak_Bud_burst_A4 Qrob_Chr11 11 s_A9OIA_166 s_1C6WBF_114 21,23 2,83 42,83 lod 5,1 7,2
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Champenoux_2015_nSecLBD_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 25,78 25,47 27,72 lod 6.3 16.6

0 Targeting