Protein : Qrob_P0086780.2 Q. robur
Protein Identifier  ? Qrob_P0086780.2 Organism . Name  Quercus robur
Score  92.0 Score Type  egn
Protein Description  (M=2) PTHR10315//PTHR10315:SF24 - SEVEN IN ABSENTIA HOMOLOG // SUBFAMILY NOT NAMED Code Enzyme  EC:6.3.2.19
Gene Prediction Quality  validated Protein length 

Sequence

Length: 258  
Kegg Orthology  K04506
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0 Synonyms

7 GO Terms

Identifier Name Description
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0008270 zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
GO:0004842 ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
GO:0016567 protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

22 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa006254mg 21 250 + 230 Gaps:4 54.76 420 56.96 4e-87 hypothetical protein
blastp_kegg lcl|pmum:103328701 21 242 + 222 Gaps:2 52.13 422 58.64 5e-87 putative E3 ubiquitin-protein ligase SINA-like 6
blastp_kegg lcl|fve:101305776 21 243 + 223 Gaps:1 62.54 355 57.21 4e-85 E3 ubiquitin-protein ligase SINA-like 10-like
blastp_kegg lcl|rcu:RCOM_0326980 21 241 + 221 Gaps:1 59.36 374 58.56 9e-84 ubiquitin-protein ligase putative
blastp_kegg lcl|cmo:103499310 21 241 + 221 Gaps:1 62.86 350 57.27 1e-82 E3 ubiquitin-protein ligase SINA-like 7
blastp_kegg lcl|cic:CICLE_v10012174mg 21 238 + 218 Gaps:1 66.16 328 54.84 3e-80 hypothetical protein
blastp_kegg lcl|cit:102613468 21 238 + 218 Gaps:1 65.76 330 54.38 1e-79 E3 ubiquitin-protein ligase SINA-like 10-like
blastp_kegg lcl|mdm:103444341 21 236 + 216 Gaps:4 60.06 363 55.05 1e-77 E3 ubiquitin-protein ligase SINA-like 10
blastp_kegg lcl|pxb:103961031 21 236 + 216 Gaps:4 48.34 451 55.96 3e-77 putative E3 ubiquitin-protein ligase SINA-like 6
blastp_kegg lcl|tcc:TCM_019286 21 240 + 220 Gaps:3 60.88 363 53.85 6e-77 RING/U-box and TRAF-like domains putative isoform 1
blastp_uniprot_sprot sp|Q84K34|SIL10_ARATH 21 236 + 216 Gaps:1 62.18 349 37.79 5e-50 E3 ubiquitin-protein ligase SINA-like 10 OS Arabidopsis thaliana GN At5g37930 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FKD9|SINL6_ARATH 21 230 + 210 Gaps:7 75.80 281 38.50 1e-44 Putative E3 ubiquitin-protein ligase SINA-like 6 OS Arabidopsis thaliana GN At5g37870 PE 3 SV 1
blastp_uniprot_sprot sp|Q9FKD7|SINL7_ARATH 24 234 + 211 Gaps:5 75.52 286 37.50 4e-43 E3 ubiquitin-protein ligase SINA-like 7 OS Arabidopsis thaliana GN At5g37890 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FKD5|SINL9_ARATH 24 236 + 213 Gaps:7 78.99 276 35.78 7e-40 Putative E3 ubiquitin-protein ligase SINA-like 9 OS Arabidopsis thaliana GN At5g37910 PE 3 SV 1
blastp_uniprot_sprot sp|Q9C6H3|SINL2_ARATH 21 238 + 218 Gaps:6 70.93 313 36.49 1e-39 E3 ubiquitin-protein ligase SINA-like 2 OS Arabidopsis thaliana GN At1g66620 PE 2 SV 1
blastp_uniprot_sprot sp|Q9C6H2|SINL3_ARATH 21 240 + 220 Gaps:21 79.54 303 34.02 4e-36 E3 ubiquitin-protein ligase SINA-like 3 OS Arabidopsis thaliana GN At1g66630 PE 2 SV 1
blastp_uniprot_sprot sp|Q9C9M0|SINL4_ARATH 21 236 + 216 Gaps:10 68.09 329 35.71 3e-35 E3 ubiquitin-protein ligase SINA-like 4 OS Arabidopsis thaliana GN At1g66650 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FM14|SIL11_ARATH 24 220 + 197 Gaps:7 64.97 314 36.76 5e-32 E3 ubiquitin-protein ligase SINA-like 11 OS Arabidopsis thaliana GN At5g62800 PE 2 SV 2
blastp_uniprot_sprot sp|Q9FKD6|SINL8_ARATH 21 226 + 206 Gaps:16 76.81 263 31.68 2e-29 E3 ubiquitin-protein ligase SINA-like 8 OS Arabidopsis thaliana GN At5g37900 PE 1 SV 2
blastp_uniprot_sprot sp|Q7XA77|SINL5_ARATH 21 236 + 216 Gaps:11 67.99 328 34.98 2e-26 E3 ubiquitin-protein ligase SINA-like 5 OS Arabidopsis thaliana GN At1g66660 PE 2 SV 2
rpsblast_cdd gnl|CDD|190542 53 120 + 68 Gaps:2 35.35 198 31.43 1e-11 pfam03145 Sina Seven in absentia protein family. The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of functional Sina results in the transformation of the R7 precursor cell to a non- neuronal cell type. The Sina protein contains an N-terminal RING finger domain pfam00097. Through this domain Sina binds E2 ubiquitin-conjugating enzymes (UbcD1) Sina also interacts with Tramtrack (TTK88) via PHYL. Tramtrack is a transcriptional repressor that blocks photoreceptor determination while PHYL down-regulates the activity of TTK88. In turn the activity of PHYL requires the activation of the Sevenless receptor tyrosine kinase a process essential for R7 determination. It is thought that thus Sina targets TTK88 for degradation therefore promoting the R7 pathway. Murine and human homologues of Sina have also been identified. The human homologue Siah-1 also binds E2 enzymes (UbcH5) and through a series of physical interactions targets beta-catenin for ubiquitin degradation. Siah-1 expression is enhanced by p53 itself promoted by DNA damage. Thus this pathway links DNA damage to beta-catenin degradation. Sina proteins therefore physically interact with a variety of proteins. The N-terminal RING finger domain that binds ubiquitin conjugating enzymes is described in pfam00097 and does not form part of the alignment for this family. The remainder C-terminal part is involved in interactions with other proteins and is included in this alignment. In addition to the Drosophila protein and mammalian homologues whose similarity was noted previously this family also includes putative homologues from Caenorhabditis elegans Arabidopsis thaliana.
rpsblast_kog gnl|CDD|38212 24 239 + 216 Gaps:12 76.25 299 38.60 2e-36 KOG3002 KOG3002 KOG3002 Zn finger protein [General function prediction only].

7 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSiteProfiles 63 121 59 PS51081 "UniPathway:UPA00143" Zinc finger SIAH-type profile. IPR013010
Gene3D 77 116 40 G3DSA:3.90.890.10 none none IPR013323
Pfam 53 209 157 PF03145 "UniPathway:UPA00143" Seven in absentia protein family IPR018121
PANTHER 24 240 217 PTHR10315:SF24 none none none
PANTHER 24 240 217 PTHR10315 "UniPathway:UPA00143";signature_desc=SEVEN IN ABSENTIA HOMOLOG none IPR004162
SUPERFAMILY 63 236 174 SSF49599 none none IPR008974
Gene3D 21 76 56 G3DSA:3.30.40.10 none none IPR013083

0 Localization

12 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran2_2004_QTL9_peak_Bud_burst_3P Qrob_Chr02 2 s_1C34E9_788 v_12238_322 50 25 75 lod 4,4 10,1
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL2_d13Cf Qrob_Chr02 2 s_1AQA4Z_1644 s_1AK5QX_947 53.67 14,01 79,68 lod 5.6594 0.03
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran_2000_2002_QTL2_Delta.F Qrob_Chr02 2 s_1CSO13_1244 s_1AVEUF_1540 55.44 46,71 63,68 lod 7.3232 0.058
Bourran2_2002_QTL7_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 29 52 lod 8,1 16
Bourran2_2002_QTL9_peak_Bud_burst_A4 Qrob_Chr02 2 s_1BFNDA_375 s_1A3VA1_2139 32,5 17 62 lod 3,1 4,2
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nP_A4 Qrob_Chr02 2 s_1A0FUE_1868 s_1A1UAI_500 20,64 20,47 21,36 lod 5.8 10.9
Bourran2_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 24,87 24,63 26,18 lod 3.8 7
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL6_d13Cf Qrob_Chr02 2 s_1AEP21_172 v_6048_204 46.33 22,5 65,23 lod 4.972 0.03

0 Targeting