Protein : Qrob_P0075450.2 Q. robur
Protein Identifier  ? Qrob_P0075450.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) 1.2.1.27 - Methylmalonate-semialdehyde dehydrogenase (acylating). Code Enzyme  EC:1.2.1.27
Gene Prediction Quality  validated Protein length 

Sequence

Length: 542  
Kegg Orthology  K00140
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.

48 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa003960mg 1 540 + 540 Gaps:4 99.63 538 89.55 0.0 hypothetical protein
blastp_kegg lcl|pmum:103335834 1 540 + 540 Gaps:4 99.63 538 89.55 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|rcu:RCOM_0818850 1 540 + 540 Gaps:4 99.45 541 88.48 0.0 methylmalonate-semialdehyde dehydrogenase putative (EC:1.2.1.27)
blastp_kegg lcl|vvi:100266351 1 540 + 540 Gaps:4 99.44 539 87.69 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|gmx:100811544 1 540 + 540 Gaps:4 99.08 541 86.38 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|cmo:103495370 1 539 + 539 Gaps:5 99.44 537 87.27 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial
blastp_kegg lcl|gmx:100791508 1 540 + 540 Gaps:4 99.81 537 85.63 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|pop:POPTR_0009s08220g 2 540 + 539 Gaps:6 99.08 542 86.22 0.0 POPTRDRAFT_202375 methylmalonate-semialdehyde dehydrogenase family protein
blastp_kegg lcl|pxb:103955126 1 540 + 540 Gaps:5 99.63 539 87.52 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial
blastp_kegg lcl|tcc:TCM_007348 1 540 + 540 Gaps:4 99.44 539 86.94 0.0 Aldehyde dehydrogenase 6B2
blastp_pdb 4e4g_H 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_G 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_F 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_E 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_D 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_C 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_B 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_A 53 540 + 488 Gaps:12 94.82 521 48.38 5e-153 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 1t90_D 46 523 + 478 Gaps:4 97.94 486 44.54 7e-141 mol:protein length:486 Probable methylmalonate-semialdehyde dehydrog
blastp_pdb 1t90_C 46 523 + 478 Gaps:4 97.94 486 44.54 7e-141 mol:protein length:486 Probable methylmalonate-semialdehyde dehydrog
blastp_uniprot_sprot sp|Q0WM29|MMSA_ARATH 8 540 + 533 Gaps:4 87.15 607 82.42 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Arabidopsis thaliana GN ALDH6B2 PE 2 SV 2
blastp_uniprot_sprot sp|Q17M80|MMSA_AEDAE 31 540 + 510 Gaps:9 96.55 521 62.03 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Aedes aegypti GN AAEL001134 PE 3 SV 1
blastp_uniprot_sprot sp|P52713|MMSA_CAEEL 30 540 + 511 Gaps:4 96.94 523 59.96 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Caenorhabditis elegans GN alh-8 PE 1 SV 1
blastp_uniprot_sprot sp|Q54I10|MMSA_DICDI 12 537 + 526 Gaps:10 98.86 528 57.66 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Dictyostelium discoideum GN mmsdh PE 3 SV 1
blastp_uniprot_sprot sp|Q7QC84|MMSA_ANOGA 31 540 + 510 Gaps:9 96.55 521 61.03 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Anopheles gambiae GN AGAP002499 PE 3 SV 2
blastp_uniprot_sprot sp|Q02252|MMSA_HUMAN 50 525 + 476 none 88.97 535 61.13 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Homo sapiens GN ALDH6A1 PE 1 SV 2
blastp_uniprot_sprot sp|Q07536|MMSA_BOVIN 50 525 + 476 none 88.64 537 60.50 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Bos taurus GN ALDH6A1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9EQ20|MMSA_MOUSE 50 525 + 476 none 88.97 535 60.71 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Mus musculus GN Aldh6a1 PE 1 SV 1
blastp_uniprot_sprot sp|Q02253|MMSA_RAT 50 525 + 476 none 88.97 535 60.71 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Rattus norvegicus GN Aldh6a1 PE 1 SV 1
blastp_uniprot_sprot sp|Q7KW39|MMSA_DROME 50 540 + 491 Gaps:1 94.62 520 61.99 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Drosophila melanogaster GN CG17896 PE 2 SV 1

8 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 45 303 259 G3DSA:3.40.605.10 none none IPR016162
SUPERFAMILY 41 525 485 SSF53720 none none IPR016161
PANTHER 13 525 513 PTHR11699:SF27 "KEGG:00280+1.2.1.27","KEGG:00410+1.2.1.18","KEGG:00562+1.2.1.18","KEGG:00640+1.2.1.18+1.2.1.27","MetaCyc:PWY-5642","MetaCyc:PWY-6373";signature_desc=METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE none IPR010061
Gene3D 304 484 181 G3DSA:3.40.309.10 none none IPR016163
TIGRFAM 49 523 475 TIGR01722 "KEGG:00280+1.2.1.27","KEGG:00410+1.2.1.18","KEGG:00562+1.2.1.18","KEGG:00640+1.2.1.18+1.2.1.27","MetaCyc:PWY-5642","MetaCyc:PWY-6373" MMSDH: methylmalonate-semialdehyde dehydrogenase (acylating) IPR010061
ProSitePatterns 317 328 12 PS00070 none Aldehyde dehydrogenases cysteine active site. IPR016160
PANTHER 13 525 513 PTHR11699 none none none
Pfam 55 519 465 PF00171 none Aldehyde dehydrogenase family IPR015590

0 Localization

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2002_QTL16_peak_Bud_burst_A4 Qrob_Chr11 11 s_A9OIA_166 s_1C6WBF_114 21,23 2,83 42,83 lod 5,1 7,2
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Champenoux_2015_nSecLBD_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 25,78 25,47 27,72 lod 6.3 16.6
Bourran2_2014_nP_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 7,9 0,09 30,09 lod 2,3636 5

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 28   Mitochondrion 1 0.018 0.934 NON-PLANT 28