Protein : Qrob_P0075440.2 Q. robur
Protein Identifier  ? Qrob_P0075440.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) 1.2.1.27 - Methylmalonate-semialdehyde dehydrogenase (acylating). Code Enzyme  EC:1.2.1.27
Gene Prediction Quality  validated Protein length 

Sequence

Length: 710  
Kegg Orthology  K00140
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.

48 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103335833 1 697 + 697 none 99.86 698 86.66 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|rcu:RCOM_0818840 1 709 + 709 none 100.00 709 83.22 0.0 methylmalonate-semialdehyde dehydrogenase putative (EC:1.2.1.27)
blastp_kegg lcl|pper:PRUPE_ppa002231mg 1 696 + 696 none 99.71 698 86.49 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_046720 1 709 + 709 Gaps:1 99.86 709 83.47 0.0 Aldehyde dehydrogenase 6B2
blastp_kegg lcl|vvi:100261145 1 708 + 708 Gaps:2 99.44 712 82.91 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|pop:POPTR_0009s08230g 14 709 + 696 none 97.62 713 84.05 0.0 POPTRDRAFT_1087520 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10030282mg 1 699 + 699 none 100.00 699 82.69 0.0 hypothetical protein
blastp_kegg lcl|cit:102627595 1 699 + 699 Gaps:49 95.77 781 76.87 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|fve:101305026 1 697 + 697 Gaps:1 99.86 697 80.75 0.0 methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial-like
blastp_kegg lcl|vvi:100254417 1 707 + 707 Gaps:6 67.40 1040 73.04 0.0 uncharacterized LOC100254417
blastp_pdb 4e4g_H 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_G 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_F 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_E 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_D 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_C 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_B 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 4e4g_A 205 693 + 489 Gaps:2 94.24 521 44.81 1e-138 mol:protein length:521 Methylmalonate-semialdehyde dehydrogenase
blastp_pdb 1t90_D 216 693 + 478 Gaps:6 97.94 486 42.65 1e-130 mol:protein length:486 Probable methylmalonate-semialdehyde dehydrog
blastp_pdb 1t90_C 216 693 + 478 Gaps:6 97.94 486 42.65 1e-130 mol:protein length:486 Probable methylmalonate-semialdehyde dehydrog
blastp_uniprot_sprot sp|Q0WM29|MMSA_ARATH 186 709 + 524 Gaps:3 86.16 607 74.95 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Arabidopsis thaliana GN ALDH6B2 PE 2 SV 2
blastp_uniprot_sprot sp|Q02252|MMSA_HUMAN 205 708 + 504 Gaps:6 95.33 535 54.71 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Homo sapiens GN ALDH6A1 PE 1 SV 2
blastp_uniprot_sprot sp|Q02253|MMSA_RAT 215 708 + 494 Gaps:1 92.52 535 55.56 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Rattus norvegicus GN Aldh6a1 PE 1 SV 1
blastp_uniprot_sprot sp|Q07536|MMSA_BOVIN 215 708 + 494 Gaps:1 92.18 537 55.15 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Bos taurus GN ALDH6A1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9EQ20|MMSA_MOUSE 215 708 + 494 Gaps:1 92.52 535 54.75 0.0 Methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Mus musculus GN Aldh6a1 PE 1 SV 1
blastp_uniprot_sprot sp|P52713|MMSA_CAEEL 215 695 + 481 none 91.97 523 58.42 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Caenorhabditis elegans GN alh-8 PE 1 SV 1
blastp_uniprot_sprot sp|Q54I10|MMSA_DICDI 220 706 + 487 Gaps:1 92.42 528 55.53 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Dictyostelium discoideum GN mmsdh PE 3 SV 1
blastp_uniprot_sprot sp|Q17M80|MMSA_AEDAE 208 708 + 501 Gaps:1 96.35 521 56.18 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Aedes aegypti GN AAEL001134 PE 3 SV 1
blastp_uniprot_sprot sp|Q7QC84|MMSA_ANOGA 190 708 + 519 Gaps:5 99.04 521 54.07 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Anopheles gambiae GN AGAP002499 PE 3 SV 2
blastp_uniprot_sprot sp|Q7KW39|MMSA_DROME 215 708 + 494 Gaps:1 95.19 520 55.76 0.0 Probable methylmalonate-semialdehyde dehydrogenase [acylating] mitochondrial OS Drosophila melanogaster GN CG17896 PE 2 SV 1

8 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 184 695 512 PTHR11699:SF27 "KEGG:00280+1.2.1.27","KEGG:00410+1.2.1.18","KEGG:00562+1.2.1.18","KEGG:00640+1.2.1.18+1.2.1.27","MetaCyc:PWY-5642","MetaCyc:PWY-6373";signature_desc=METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE none IPR010061
SUPERFAMILY 209 695 487 SSF53720 none none IPR016161
Pfam 225 689 465 PF00171 none Aldehyde dehydrogenase family IPR015590
PANTHER 184 695 512 PTHR11699 none none none
TIGRFAM 219 693 475 TIGR01722 "KEGG:00280+1.2.1.27","KEGG:00410+1.2.1.18","KEGG:00562+1.2.1.18","KEGG:00640+1.2.1.18+1.2.1.27","MetaCyc:PWY-5642","MetaCyc:PWY-6373" MMSDH: methylmalonate-semialdehyde dehydrogenase (acylating) IPR010061
Gene3D 474 653 180 G3DSA:3.40.309.10 none none IPR016163
Gene3D 216 473 258 G3DSA:3.40.605.10 none none IPR016162
ProSitePatterns 487 498 12 PS00070 none Aldehyde dehydrogenases cysteine active site. IPR016160

0 Localization

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2002_QTL16_peak_Bud_burst_A4 Qrob_Chr11 11 s_A9OIA_166 s_1C6WBF_114 21,23 2,83 42,83 lod 5,1 7,2
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Champenoux_2015_nSecLBD_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 25,78 25,47 27,72 lod 6.3 16.6
Bourran2_2014_nP_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 7,9 0,09 30,09 lod 2,3636 5

0 Targeting