Protein : Qrob_P0058420.2 Q. robur

Protein Identifier  ? Qrob_P0058420.2 Organism . Name  Quercus robur
Score  10.1 Score Type  egn
Protein Description  (M=5) 5.1.3.15 - Glucose-6-phosphate 1-epimerase. Code Enzyme  EC:5.1.3.15
Gene Prediction Quality  validated Protein length 

Sequence

Length: 320  
Kegg Orthology  K01792

Sequence Feature Displayer

Protein Sequence Displayer

J Browse Displayer

0 Synonyms

4 GO Terms

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
GO:0030246 carbohydrate binding Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
GO:0016853 isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

32 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_029282 7 319 + 313 none 99.68 314 85.62 0.0 Glucose-6-phosphate 1-epimerase putative
blastp_kegg lcl|pmum:103328247 1 319 + 319 none 100.00 319 84.95 0.0 putative glucose-6-phosphate 1-epimerase
blastp_kegg lcl|pper:PRUPE_ppa008778mg 1 319 + 319 none 100.00 319 84.95 0.0 hypothetical protein
blastp_kegg lcl|mdm:103432216 1 319 + 319 none 99.69 320 84.01 0.0 putative glucose-6-phosphate 1-epimerase
blastp_kegg lcl|vvi:100259893 7 317 + 311 none 99.04 314 84.89 0.0 putative glucose-6-phosphate 1-epimerase-like
blastp_kegg lcl|pxb:103960247 1 319 + 319 none 99.69 320 83.39 0.0 putative glucose-6-phosphate 1-epimerase
blastp_kegg lcl|pop:POPTR_0001s07480g 7 318 + 312 none 97.81 319 86.86 0.0 POPTRDRAFT_178246 hypothetical protein
blastp_kegg lcl|pxb:103945403 1 319 + 319 none 99.69 320 83.39 0.0 putative glucose-6-phosphate 1-epimerase
blastp_kegg lcl|pop:POPTR_0003s18620g 7 318 + 312 none 97.81 319 85.26 0.0 POPTRDRAFT_831004 hypothetical protein
blastp_kegg lcl|cit:102620138 2 318 + 317 Gaps:1 86.65 367 82.08 0.0 putative glucose-6-phosphate 1-epimerase-like
blastp_pdb 2cis_A 33 309 + 277 Gaps:25 93.60 297 35.61 3e-39 mol:protein length:297 GLUCOSE-6-PHOSPHATE 1-EPIMERASE
blastp_pdb 2cir_A 33 309 + 277 Gaps:25 93.60 297 35.61 3e-39 mol:protein length:297 HEXOSE-6-PHOSPHATE MUTAROTASE
blastp_pdb 2ciq_A 33 309 + 277 Gaps:25 93.60 297 35.61 3e-39 mol:protein length:297 HEXOSE-6-PHOSPHATE MUTAROTASE
blastp_pdb 2htb_D 35 283 + 249 Gaps:16 76.70 309 33.33 2e-28 mol:protein length:309 Putative enzyme related to aldose 1-epimerase
blastp_pdb 2htb_C 35 283 + 249 Gaps:16 76.70 309 33.33 2e-28 mol:protein length:309 Putative enzyme related to aldose 1-epimerase
blastp_pdb 2htb_B 35 283 + 249 Gaps:16 76.70 309 33.33 2e-28 mol:protein length:309 Putative enzyme related to aldose 1-epimerase
blastp_pdb 2htb_A 35 283 + 249 Gaps:16 76.70 309 33.33 2e-28 mol:protein length:309 Putative enzyme related to aldose 1-epimerase
blastp_pdb 2hta_B 35 283 + 249 Gaps:16 76.70 309 33.33 2e-28 mol:protein length:309 Putative enzyme related to aldose 1-epimerase
blastp_pdb 2hta_A 35 283 + 249 Gaps:16 76.70 309 33.33 2e-28 mol:protein length:309 Putative enzyme related to aldose 1-epimerase
blastp_pdb 1jov_A 34 278 + 245 Gaps:50 81.11 270 36.07 3e-23 mol:protein length:270 HI1317
blastp_uniprot_sprot sp|Q40784|AAPC_CENCI 12 317 + 306 none 93.01 329 75.49 2e-175 Putative glucose-6-phosphate 1-epimerase OS Cenchrus ciliaris PE 2 SV 1
blastp_uniprot_sprot sp|Q03161|YMY9_YEAST 33 309 + 277 Gaps:25 93.60 297 35.61 1e-38 Glucose-6-phosphate 1-epimerase OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN YMR099C PE 1 SV 1
blastp_uniprot_sprot sp|P39173|YEAD_ECOLI 35 278 + 244 Gaps:28 78.91 294 37.07 2e-28 Putative glucose-6-phosphate 1-epimerase OS Escherichia coli (strain K12) GN yeaD PE 1 SV 2
blastp_uniprot_sprot sp|P44160|Y1317_HAEIN 53 278 + 226 Gaps:49 73.43 271 35.68 2e-18 Putative glucose-6-phosphate 1-epimerase OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN HI_1317 PE 3 SV 1
rpsblast_cdd gnl|CDD|185697 32 299 + 268 Gaps:12 97.40 269 48.85 1e-101 cd09020 D-hex-6-P-epi_like D-hexose-6-phosphate epimerase-like. D-Hexose-6-phosphate epimerase Ymr099c from Saccharomyces cerevisiae belongs to the large superfamily of aldose-1-epimerases. Its active site is very similar to the catalytic site of galactose mutarotase the best studied member of the superfamily. It also contains the conserved glutamate and histidine residues that have been shown in galactose mutarotase to be critical for catalysis the glutamate serving as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen. In addition Ymr099c contains 2 conserved arginine residues which are involved in phosphate binding and exhibits hexose-6-phosphate mutarotase activity on glucose-6-P galactose-6-P and mannose-6-P.
rpsblast_cdd gnl|CDD|201693 24 299 + 276 Gaps:48 99.67 301 29.33 2e-58 pfam01263 Aldose_epim Aldose 1-epimerase.
rpsblast_cdd gnl|CDD|31020 33 302 + 270 Gaps:21 88.15 287 37.94 2e-53 COG0676 COG0676 Uncharacterized enzymes related to aldose 1-epimerase [Carbohydrate transport and metabolism].
rpsblast_cdd gnl|CDD|185702 41 276 + 236 Gaps:41 80.81 271 30.14 1e-24 cd09025 Aldose_epim_Slr1438 Aldose 1-epimerase similar to Synechocystis Slr1438. Proteins similar to Synechocystis Slr1438 are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family galactose mutarotase have shown a glutamate and a histidine residue to be critical for catalysis the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.
rpsblast_cdd gnl|CDD|185695 35 276 + 242 Gaps:55 88.38 284 21.51 9e-15 cd01081 Aldose_epim aldose 1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism they catalyze the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family galactose mutarotase have shown a glutamate and a histidine residue to be critical for catalysis the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.
rpsblast_cdd gnl|CDD|185701 41 243 + 203 Gaps:55 63.19 288 26.92 2e-08 cd09024 Aldose_epim_lacX Aldose 1-epimerase similar to Lactococcus lactis lacX. Proteins similar to Lactococcus lactis lacX are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family galactose mutarotase have shown a glutamate and a histidine residue to be critical for catalysis the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 13 306 294 PTHR11122 none none none
PANTHER 13 306 294 PTHR11122:SF11 none none none
Pfam 27 298 272 PF01263 none Aldose 1-epimerase IPR008183
PIRSF 3 305 303 PIRSF016020 "KEGG:00010+5.1.3.15","MetaCyc:PWY-2723","MetaCyc:PWY-5384","MetaCyc:PWY-5940","MetaCyc:PWY-621","MetaCyc:PWY-622","MetaCyc:PWY-6731","MetaCyc:PWY-6737","MetaCyc:PWY-6981","MetaCyc:PWY-7238","MetaCyc:PWY-7343" none IPR025532
Gene3D 7 299 293 G3DSA:2.70.98.10 none none IPR014718
SUPERFAMILY 31 298 268 SSF74650 none none IPR011013

0 Localization

0 Qtllist

0 Targeting