Protein : Qrob_P0041470.2 Q. robur
Protein Identifier  ? Qrob_P0041470.2 Organism . Name  Quercus robur
Score  84.0 Score Type  egn
Protein Description  (M=2) PTHR13620//PTHR13620:SF3 - 3-5 EXONUCLEASE // SUBFAMILY NOT NAMED Code Enzyme  EC:3.6.4.12
Gene Prediction Quality  validated Protein length 

Sequence

Length: 133  
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa023705mg 23 125 + 103 none 42.21 244 72.82 2e-44 hypothetical protein
blastp_kegg lcl|pmum:103322662 23 125 + 103 none 32.19 320 72.82 3e-44 Werner Syndrome-like exonuclease
blastp_kegg lcl|gmx:100801291 23 124 + 102 Gaps:1 34.59 292 69.31 2e-43 Werner Syndrome-like exonuclease-like
blastp_kegg lcl|pxb:103962556 27 125 + 99 none 30.65 323 74.75 1e-42 Werner Syndrome-like exonuclease
blastp_kegg lcl|mdm:103443411 27 125 + 99 none 30.65 323 74.75 1e-42 Werner Syndrome-like exonuclease
blastp_kegg lcl|vvi:100264183 5 125 + 121 Gaps:3 37.46 331 61.29 2e-42 Werner Syndrome-like exonuclease-like
blastp_kegg lcl|mtr:MTR_3g084280 23 124 + 102 none 32.80 311 66.67 2e-40 Werner syndrome ATP-dependent helicase
blastp_kegg lcl|cic:CICLE_v10005507mg 1 127 + 127 none 48.47 262 55.12 3e-40 hypothetical protein
blastp_kegg lcl|pvu:PHAVU_001G266900g 27 124 + 98 Gaps:1 33.11 293 69.07 7e-40 hypothetical protein
blastp_kegg lcl|cit:102616461 23 124 + 102 none 33.55 304 65.69 8e-40 Werner Syndrome-like exonuclease-like
blastp_pdb 2fc0_A 30 125 + 96 Gaps:2 46.83 205 34.38 5e-13 mol:protein length:205 Werner syndrome helicase
blastp_pdb 2fby_A 30 125 + 96 Gaps:2 46.83 205 34.38 5e-13 mol:protein length:205 Werner syndrome helicase
blastp_pdb 2fbx_A 30 125 + 96 Gaps:2 46.83 205 34.38 5e-13 mol:protein length:205 Werner syndrome helicase
blastp_pdb 2fbv_A 30 125 + 96 Gaps:2 46.83 205 34.38 5e-13 mol:protein length:205 Werner syndrome helicase
blastp_pdb 2fbt_A 30 125 + 96 Gaps:2 46.83 205 34.38 5e-13 mol:protein length:205 Werner syndrome helicase
blastp_pdb 2e6m_A 29 125 + 97 Gaps:5 48.08 208 34.00 2e-12 mol:protein length:208 Werner syndrome ATP-dependent helicase homolo
blastp_pdb 2e6l_A 29 125 + 97 Gaps:5 48.08 208 34.00 2e-12 mol:protein length:208 Werner syndrome ATP-dependent helicase homolo
blastp_uniprot_sprot sp|Q84LH3|WEX_ARATH 23 125 + 103 Gaps:1 35.42 288 61.76 2e-35 Werner Syndrome-like exonuclease OS Arabidopsis thaliana GN WEX PE 1 SV 1
blastp_uniprot_sprot sp|O93530|WRN_XENLA 30 126 + 97 Gaps:3 6.69 1436 40.62 4e-12 Werner syndrome ATP-dependent helicase homolog OS Xenopus laevis GN wrn PE 2 SV 1
blastp_uniprot_sprot sp|Q14191|WRN_HUMAN 30 125 + 96 Gaps:2 6.70 1432 33.33 3e-11 Werner syndrome ATP-dependent helicase OS Homo sapiens GN WRN PE 1 SV 2
blastp_uniprot_sprot sp|O09053|WRN_MOUSE 29 125 + 97 Gaps:5 7.14 1401 34.00 1e-10 Werner syndrome ATP-dependent helicase homolog OS Mus musculus GN Wrn PE 1 SV 3
rpsblast_cdd gnl|CDD|176653 29 123 + 95 Gaps:3 55.29 170 35.11 7e-19 cd06141 WRN_exo DEDDy 3'-5' exonuclease domain of WRN and similar proteins. WRN is a unique RecQ DNA helicase exhibiting an exonuclease activity. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Mutations in the WRN gene cause Werner syndrome an autosomal recessive disorder associated with premature aging and increased susceptibility to cancer and type II diabetes. WRN interacts with key proteins involved in DNA replication recombination and repair. It is believed to maintain genomic stability and life span by participating in DNA processes. WRN is stimulated by Ku70/80 an important regulator of genomic stability.
rpsblast_cdd gnl|CDD|176650 30 122 + 93 Gaps:3 57.14 161 29.35 3e-08 cd06129 RNaseD_like DEDDy 3'-5' exonuclease domain of RNase D WRN and similar proteins. The RNase D-like group is composed of RNase D WRN and similar proteins. They contain a DEDDy-type DnaQ-like 3'-5' exonuclease domain that contains three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. RNase D is involved in the 3'-end processing of tRNA precursors. RNase D-like proteins in eukaryotes include yeast Rrp6p human PM/Scl-100 and Drosophila melanogaster egalitarian (Egl) protein. WRN is a unique DNA helicase possessing exonuclease activity. Mutation in the WRN gene is implicated in Werner syndrome a disease associated with premature aging and increased predisposition to cancer. Yeast Rrp6p and the human Polymyositis/scleroderma autoantigen 100kDa (PM/Scl-100) are exosome-associated proteins involved in the degradation and processing of precursors to stable RNAs. Egl is a component of an mRNA-binding complex which is required for oocyte specification. The Egl subfamily does not possess a completely conserved YX(3)D pattern at the ExoIII motif.
rpsblast_cdd gnl|CDD|176656 30 125 + 96 Gaps:2 64.00 150 19.79 7e-07 cd09018 DEDDy_polA_RNaseD_like_exo DEDDy 3'-5' exonuclease domain of family-A DNA polymerases RNase D WRN and similar proteins. DEDDy exonucleases part of the DnaQ-like (or DEDD) exonuclease superfamily catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. They contain four invariant acidic residues in three conserved sequence motifs termed ExoI ExoII and ExoIII. DEDDy exonucleases are classified as such because of the presence of a specific YX(3)D pattern at ExoIII. The four conserved acidic residues serve as ligands for the two metal ions required for catalysis. This family of DEDDy exonucleases includes the proofreading domains of family A DNA polymerases as well as RNases such as RNase D and yeast Rrp6p. The Egalitarian (Egl) and Bacillus-like DNA Polymerase I subfamilies do not possess a completely conserved YX(3)D pattern at the ExoIII motif. In addition the Bacillus-like DNA polymerase I subfamily has inactive 3'-5' exonuclease domains which do not possess the metal-binding residues necessary for activity.
rpsblast_kog gnl|CDD|39574 26 124 + 99 Gaps:5 32.60 319 27.88 8e-15 KOG4373 KOG4373 KOG4373 Predicted 3'-5' exonuclease [General function prediction only].

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 30 123 94 PF01612 none 3'-5' exonuclease IPR002562
PANTHER 29 125 97 PTHR13620 none none none
Gene3D 28 122 95 G3DSA:3.30.420.10 none none IPR012337
PANTHER 29 125 97 PTHR13620:SF3 none none none
SUPERFAMILY 26 121 96 SSF53098 none none IPR012337

0 Localization

0 Qtllist

0 Targeting