Protein : Qrob_P0010090.2 Q. robur
Protein Identifier  ? Qrob_P0010090.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) K03100 - signal peptidase I [EC:3.4.21.89] Code Enzyme  EC:3.4.21.89
Gene Prediction Quality  validated Protein length 

Sequence

Length: 302  
Kegg Orthology  K03100
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0006508 proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0008236 serine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

29 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103340969 1 301 + 301 Gaps:12 88.86 341 74.26 4e-150 chloroplast processing peptidase
blastp_kegg lcl|pper:PRUPE_ppa008221mg 1 300 + 300 Gaps:11 88.53 340 75.08 1e-149 hypothetical protein
blastp_kegg lcl|pxb:103960693 1 301 + 301 Gaps:11 90.48 336 72.70 8e-142 chloroplast processing peptidase-like
blastp_kegg lcl|pxb:103946436 1 301 + 301 Gaps:19 90.48 336 72.70 3e-141 chloroplast processing peptidase-like
blastp_kegg lcl|mdm:103418020 1 301 + 301 Gaps:11 93.83 324 72.04 2e-139 chloroplast processing peptidase-like
blastp_kegg lcl|mdm:103448872 1 301 + 301 Gaps:11 93.83 324 72.04 2e-139 chloroplast processing peptidase-like
blastp_kegg lcl|pxb:103962974 1 301 + 301 Gaps:11 93.83 324 70.72 3e-139 chloroplast processing peptidase
blastp_kegg lcl|vvi:100252527 1 298 + 298 Gaps:15 93.11 334 69.45 4e-139 chloroplast processing peptidase-like
blastp_kegg lcl|mdm:103400495 1 301 + 301 Gaps:11 93.83 324 70.39 9e-139 chloroplast processing peptidase
blastp_kegg lcl|fve:101296317 1 301 + 301 Gaps:13 97.37 304 74.32 1e-138 chloroplast processing peptidase-like
blastp_uniprot_sprot sp|Q8H0W1|PLSP1_ARATH 1 294 + 294 Gaps:16 98.97 291 68.75 2e-121 Chloroplast processing peptidase OS Arabidopsis thaliana GN PLSP1 PE 2 SV 2
blastp_uniprot_sprot sp|O04348|TPP1_ARATH 87 284 + 198 Gaps:3 59.12 340 59.20 2e-79 Thylakoidal processing peptidase 1 chloroplastic OS Arabidopsis thaliana GN TPP1 PE 2 SV 2
blastp_uniprot_sprot sp|Q9M9Z2|TPP2_ARATH 101 284 + 184 none 50.14 367 63.04 1e-76 Probable thylakoidal processing peptidase 2 chloroplastic OS Arabidopsis thaliana GN TPP2 PE 2 SV 1
blastp_uniprot_sprot sp|Q51876|LEP_PHOLA 119 281 + 163 none 80.30 203 46.63 3e-49 Signal peptidase I OS Phormidium laminosum GN lepB PE 3 SV 1
blastp_uniprot_sprot sp|P72660|LEP1_SYNY3 132 279 + 148 none 75.51 196 55.41 5e-49 Probable signal peptidase I-1 OS Synechocystis sp. (strain PCC 6803 / Kazusa) GN lepB1 PE 3 SV 1
blastp_uniprot_sprot sp|P73157|LEP2_SYNY3 100 280 + 181 Gaps:6 80.28 218 44.57 7e-45 Probable signal peptidase I-2 OS Synechocystis sp. (strain PCC 6803 / Kazusa) GN lepB2 PE 3 SV 1
blastp_uniprot_sprot sp|Q10789|LEP_MYCTU 121 279 + 159 Gaps:53 72.11 294 33.49 3e-21 Signal peptidase I OS Mycobacterium tuberculosis GN lepB PE 1 SV 1
blastp_uniprot_sprot sp|O33021|LEP_MYCLE 121 282 + 162 Gaps:62 76.82 289 31.53 7e-20 Probable signal peptidase I OS Mycobacterium leprae (strain TN) GN lepB PE 3 SV 1
blastp_uniprot_sprot sp|P26844|LEP_PSEFL 118 276 + 159 Gaps:62 72.18 284 34.15 6e-17 Signal peptidase I OS Pseudomonas fluorescens GN lepB PE 3 SV 1
blastp_uniprot_sprot sp|P28628|LEPS_BACSU 95 283 + 189 Gaps:33 97.83 184 32.78 7e-17 Signal peptidase I S OS Bacillus subtilis (strain 168) GN sipS PE 1 SV 1
rpsblast_cdd gnl|CDD|211726 118 278 + 161 Gaps:15 99.39 163 37.04 1e-39 TIGR02227 sigpep_I_bact signal peptidase I bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria as well as a microsomal (endoplasmic reticulum) protein in eukaryotes.
rpsblast_cdd gnl|CDD|119398 137 269 + 133 Gaps:49 98.82 85 50.00 2e-19 cd06530 S26_SPase_I The S26 Type I signal peptidase (SPase LepB leader peptidase B leader peptidase I EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are translocated across biological membranes. The bacterial signal peptidase I which is the most intensively studied has two N-terminal transmembrane segments inserted in the plasma membrane and a hydrophilic C-terminal catalytic region that is located in the periplasmic space. Although the bacterial signal peptidase I is monomeric signal peptidases of eukaryotic cells commonly function as oligomeric complexes containing two divergent copies of the catalytic monomer. These are the IMP1 and IMP2 signal peptidases of the mitochondrial inner membrane that remove leader peptides from nuclear- and mitochondrial-encoded proteins. Also two components of the endoplasmic reticulum signal peptidase in mammals (18-kDa and 21-kDa) belong to this family and they process many proteins that enter the ER for retention or for export to the Golgi apparatus secretory vesicles plasma membranes or vacuole. An atypical member of the S26 SPase type I family is the TraF peptidase which has the remarkable activity of producing a cyclic protein of the Pseudomonas pilin system. The type I signal peptidases are unique serine proteases that utilize a serine/lysine catalytic dyad mechanism in place of the classical serine/histidine/aspartic acid catalytic triad mechanism..
rpsblast_cdd gnl|CDD|182787 91 271 + 181 Gaps:30 45.68 324 43.24 1e-12 PRK10861 PRK10861 signal peptidase I Provisional.
rpsblast_cdd gnl|CDD|151062 172 271 + 100 Gaps:9 78.99 138 30.28 4e-11 pfam10502 Peptidase_S26 Signal peptidase peptidase S26. This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesised secreted proteins. Peptidase S26 removes the hydrophobic N-terminal signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser Lys in subfamily S26A the Ser is the nucleophile in catalysis and the Lys is the general base.
rpsblast_cdd gnl|CDD|31025 121 275 + 155 Gaps:11 87.95 166 30.82 7e-11 COG0681 LepB Signal peptidase I [Intracellular trafficking and secretion].
rpsblast_cdd gnl|CDD|119396 140 269 + 130 Gaps:50 95.24 84 40.00 1e-10 cd06462 Peptidase_S24_S26 The S24 S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins LexA (EC 3.4.21.88) the repressor of genes in the cellular SOS response to DNA damage MucA and the related UmuD proteins which are lesion-bypass DNA polymerases induced in response to mitogenic DNA damage RulA a component of the rulAB locus that confers resistance to UV and RuvA which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases..
rpsblast_cdd gnl|CDD|131818 171 269 + 99 Gaps:16 67.25 171 28.70 4e-07 TIGR02771 TraF_Ti conjugative transfer signal peptidase TraF. This protein is found in apparent operons encoding elements of conjugative transfer systems. This family is homologous to a broader family of signal (leader) peptidases such as lepB. This family is present in both Ti-type and I-type conjugative systems.
rpsblast_kog gnl|CDD|35392 99 294 + 196 Gaps:24 98.86 176 47.13 1e-43 KOG0171 KOG0171 KOG0171 Mitochondrial inner membrane protease subunit IMP1 [Posttranslational modification protein turnover chaperones].
rpsblast_kog gnl|CDD|36781 145 279 + 135 Gaps:35 65.52 174 39.47 4e-13 KOG1568 KOG1568 KOG1568 Mitochondrial inner membrane protease subunit IMP2 [Posttranslational modification protein turnover chaperones Intracellular trafficking secretion and vesicular transport].

12 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSitePatterns 242 255 14 PS00761 none Signal peptidases I signature 3. IPR019758
ProSitePatterns 143 150 8 PS00501 "Reactome:REACT_15380" Signal peptidases I serine active site. IPR019756
PRINTS 237 256 20 PR00727 none Bacterial leader peptidase 1 (S26A) family signature IPR000223
PRINTS 134 150 17 PR00727 none Bacterial leader peptidase 1 (S26A) family signature IPR000223
PRINTS 193 205 13 PR00727 none Bacterial leader peptidase 1 (S26A) family signature IPR000223
SUPERFAMILY 132 281 150 SSF51306 none none IPR015927
Gene3D 131 203 73 G3DSA:2.10.109.10 none none IPR028360
Gene3D 237 282 46 G3DSA:2.10.109.10 none none IPR028360
PANTHER 93 281 189 PTHR12383:SF15 none none none
TIGRFAM 119 277 159 TIGR02227 none sigpep_I_bact: signal peptidase I IPR000223
Pfam 170 270 101 PF10502 none Signal peptidase, peptidase S26 IPR019533
PANTHER 93 281 189 PTHR12383 none none IPR000223

0 Localization

12 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran2_2004_QTL9_peak_Bud_burst_3P Qrob_Chr02 2 s_1C34E9_788 v_12238_322 50 25 75 lod 4,4 10,1
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL2_d13Cf Qrob_Chr02 2 s_1AQA4Z_1644 s_1AK5QX_947 53.67 14,01 79,68 lod 5.6594 0.03
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran_2000_2002_QTL2_Delta.F Qrob_Chr02 2 s_1CSO13_1244 s_1AVEUF_1540 55.44 46,71 63,68 lod 7.3232 0.058
Bourran2_2002_QTL7_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 29 52 lod 8,1 16
Bourran2_2002_QTL9_peak_Bud_burst_A4 Qrob_Chr02 2 s_1BFNDA_375 s_1A3VA1_2139 32,5 17 62 lod 3,1 4,2
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nP_A4 Qrob_Chr02 2 s_1A0FUE_1868 s_1A1UAI_500 20,64 20,47 21,36 lod 5.8 10.9
Bourran2_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 24,87 24,63 26,18 lod 3.8 7
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL6_d13Cf Qrob_Chr02 2 s_1AEP21_172 v_6048_204 46.33 22,5 65,23 lod 4.972 0.03

0 Targeting