GRS - Genome Report System

Sclerotinia sclerotiorum GRS

Functional annotation

SS1G_06528.1

Gene Identifier

Domain/Motif (Interproscan results)

Localization / Targeting

Blast based analysis

Analysis	Hit	start	end	length	Note	Hit coverage	Hit length	Hit pident	Hit pcons	eValue	Hit description
blastp_kegg	ssl:SS1G_06528	1	765	765	n/a	100.00	765	86.67	0.00	0.0	hypothetical protein K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	bfu:BC1G_04815	1	765	765	Gaps:36	100.00	801	76.03	3.00	0.0	hypothetical protein K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	act:ACLA_038420	155	762	608	Gaps:27	76.12	800	55.99	12.64	0.0	serine/threonine protein kinase (Prp4) putative K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	afm:AFUA_3G10520	158	762	605	Gaps:22	75.12	808	56.34	12.69	0.0	serine/threonine protein kinase (Prp4) K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	nfi:NFIA_066760	158	762	605	Gaps:22	75.31	806	56.01	13.01	0.0	serine/threonine protein kinase (Prp4) putative K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	ure:UREG_07381	158	762	605	Gaps:25	76.57	794	55.10	15.46	0.0	serine/threonine-protein kinase prp4 K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	ani:AN4936.2	124	762	639	Gaps:24	79.62	780	55.39	14.49	0.0	hypothetical protein K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	cim:CIMG_03605	158	762	605	Gaps:27	76.48	795	54.61	15.13	0.0	hypothetical protein K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	afv:AFLA_032190	219	762	544	Gaps:21	95.23	566	60.67	14.29	0.0	serine/threonine protein kinase (Prp4) putative K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
	ang:An16g04460	159	762	604	Gaps:29	74.84	795	55.63	14.45	0.0	hypothetical protein K08827 serine/threonine-protein kinase PRP4 [EC:2.7.11.1]
blastp_uniprot_sprot	sp\|Q07538\|PRP4_SCHPO	401	762	362	Gaps:17	78.20	477	57.10	16.35	1e-126	Serine/threonine-protein kinase prp4 OS Schizosaccharomyces pombe GN prp4 PE 1 SV 2
	sp\|Q08DZ2\|PRP4B_BOVIN	420	760	341	Gaps:2	33.83	1008	56.89	19.35	1e-118	Serine/threonine-protein kinase PRP4 homolog OS Bos taurus GN PRPF4B PE 2 SV 1
	sp\|Q13523\|PRP4B_HUMAN	420	760	341	Gaps:2	33.86	1007	56.89	19.35	1e-117	Serine/threonine-protein kinase PRP4 homolog OS Homo sapiens GN PRPF4B PE 1 SV 2
	sp\|Q5RKH1\|PRP4B_RAT	420	760	341	Gaps:2	33.86	1007	56.89	19.35	1e-117	Serine/threonine-protein kinase PRP4 homolog OS Rattus norvegicus GN Prpf4b PE 2 SV 1
	sp\|Q61136\|PRP4B_MOUSE	420	760	341	Gaps:2	33.86	1007	56.89	19.35	1e-117	Serine/threonine-protein kinase PRP4 homolog OS Mus musculus GN Prpf4b PE 1 SV 2
	sp\|Q5R814\|PRP4B_PONAB	420	760	341	Gaps:2	33.86	1007	56.89	19.35	1e-117	Serine/threonine-protein kinase PRP4 homolog OS Pongo abelii GN PRPF4B PE 2 SV 1
	sp\|Q54WE5\|PRP4B_DICDI	419	760	342	Gaps:5	42.29	811	49.27	21.87	2e-98	Serine/threonine-protein kinase prpf4B OS Dictyostelium discoideum GN prpf4B PE 3 SV 1
	sp\|Q9P6P3\|PPK15_SCHPO	425	761	337	Gaps:34	66.10	534	37.68	17.56	2e-55	Serine/threonine-protein kinase ppk15 OS Schizosaccharomyces pombe GN ppk15 PE 1 SV 1
	sp\|Q09690\|POM1_SCHPO	425	761	337	Gaps:22	29.16	1087	37.54	20.50	3e-53	Dual specificity protein kinase pom1 OS Schizosaccharomyces pombe GN pom1 PE 1 SV 1
	sp\|Q9XTF3\|MBK2_CAEEL	419	764	346	Gaps:9	42.23	817	37.10	18.26	5e-53	Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 OS Caenorhabditis elegans GN mbk-2 PE 1 SV 1
blastp_pdb	2wo6_B	437	762	326	Gaps:22	86.39	382	36.36	18.18	2e-46	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2wo6_A	437	762	326	Gaps:22	86.39	382	36.36	18.18	2e-46	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_D	437	762	326	Gaps:22	86.39	382	36.36	18.18	2e-46	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_C	437	762	326	Gaps:22	86.39	382	36.36	18.18	2e-46	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_B	437	762	326	Gaps:22	86.39	382	36.36	18.18	2e-46	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_A	437	762	326	Gaps:22	86.39	382	36.36	18.18	2e-46	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	3kvw_A	425	764	340	Gaps:27	78.55	429	35.01	18.69	3e-45	mol:protein length:429 Dual specificity tyrosine-phosphorylation-reg
	3k2l_A	425	764	340	Gaps:27	78.55	429	35.01	18.69	3e-45	mol:protein length:429 Dual specificity tyrosine-phosphorylation-reg
	3nr9_C	426	763	338	Gaps:40	91.85	368	33.43	20.12	2e-39	mol:protein length:368 Dual specificity protein kinase CLK2
	3nr9_B	426	763	338	Gaps:40	91.85	368	33.43	20.12	2e-39	mol:protein length:368 Dual specificity protein kinase CLK2
rpsblast_cdd	gnl\|CDD\|128516	455	760	306	Gaps:73	99.59	244	36.63	20.16	8e-56	smart00220 S_TKc Serine/Threonine protein kinases catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily.
	gnl\|CDD\|173733	444	760	317	Gaps:65	100.00	282	34.40	18.79	4e-51	cd07829 STKc_CDK_like Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase (CDK)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDKs are partly regulated by their subcellular localization which defines substrate phosphorylation and the resulting specific function. CDK1 CDK2 CDK4 and CDK6 have well-defined functions in the cell cycle such as the regulation of the early G1 phase by CDK4 or CDK6 the G1/S phase transition by CDK2 or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes showing that some CDKs can compensate for each other. For example CDK4 can compensate for the loss of CDK6 however double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH.
	gnl\|CDD\|173737	443	762	320	Gaps:54	89.09	330	34.01	19.39	4e-48	cd07834 STKc_MAPK Catalytic domain of the Serine/Threonine Kinase Mitogen-Activated Protein Kinase. Serine/Threonine Kinases (STKs) Mitogen-Activated Protein Kinase (MAPK) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK) which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase a MAP4K. There are three main typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK) c-Jun N-terminal Kinase (JNK) and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4 MAPK6 NLK and ERK7.
	gnl\|CDD\|143851	444	760	317	Gaps:81	100.00	260	32.69	19.62	8e-46	pfam00069 Pkinase Protein kinase domain.
	gnl\|CDD\|143333	450	760	311	Gaps:58	97.88	283	34.30	21.30	9e-45	cd05118 STKc_CMGC Catalytic domain of CMGC family Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) CMGC family catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs) Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs) c-Jun N-terminal kinases (JNKs) and p38 and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation.
	gnl\|CDD\|143338	442	759	318	Gaps:53	99.65	288	33.45	24.04	5e-44	cd07833 STKc_CDKL Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-dependent protein kinase like (CDKL) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs like CDKL1 and CDKL3 may be implicated in transformation and others like CDKL3 and CDKL5 are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory.
	gnl\|CDD\|128517	444	651	208	Gaps:16	91.56	225	32.52	20.39	1e-43	smart00221 STYKc Protein kinase unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.
	gnl\|CDD\|143346	443	759	317	Gaps:59	95.30	298	34.15	20.77	2e-43	cd07841 STKc_CDK7 Catalytic domain of the Serine/Threonine Kinase Cyclin-Dependent protein Kinase 7. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 7 (CDK7) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA as present in the pre-initiation complex. Following phosphorylation the CTD dissociates from the DNA which allows transcription initiation.
	gnl\|CDD\|143345	444	760	317	Gaps:52	100.00	287	32.40	22.65	8e-42	cd07840 STKc_CDK9_like Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 9 (CDK9)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes yeast BUR1 C-type plant CDKs (CdkC) and similar proteins. CDK9 BUR1 and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2 and participates in regulating transcription and alternative splicing.
	gnl\|CDD\|173623	450	638	189	Gaps:14	86.98	215	33.69	23.53	5e-41	cd00180 PKc Catalytic domain of Protein Kinases. Protein Kinases (PKs) catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases aminoglycoside phosphotransferase choline kinase phosphoinositide 3-kinase (PI3K) and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases protein tyrosine kinases (PTKs) and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation about 95% occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins such as enzymes and membrane channels are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase which in turn may act on other kinases this sequential action transmits a signal from the cell surface to target proteins which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate tissue distribution and cellular localization. PKs regulate many cellular processes including proliferation division differentiation motility survival metabolism cell-cycle progression cytoskeletal rearrangement immunity and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer.
rpsblast_kog	gnl\|CDD\|35889	2	762	761	Gaps:112	87.63	752	43.85	15.02	1e-134	KOG0670 KOG0670 KOG0670 U4/U6-associated splicing factor PRP4 [RNA processing and modification].
	gnl\|CDD\|35886	249	760	512	Gaps:25	84.13	586	30.02	16.43	2e-79	KOG0667 KOG0667 KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase [General function prediction only].
	gnl\|CDD\|35890	426	765	340	Gaps:38	82.41	415	34.80	18.71	2e-50	KOG0671 KOG0671 KOG0671 LAMMER dual specificity kinases [Signal transduction mechanisms].
	gnl\|CDD\|35877	443	759	317	Gaps:53	78.02	364	33.45	20.42	7e-47	KOG0658 KOG0658 KOG0658 Glycogen synthase kinase-3 [Carbohydrate transport and metabolism].
	gnl\|CDD\|35879	424	762	339	Gaps:46	87.74	359	31.11	21.27	2e-37	KOG0660 KOG0660 KOG0660 Mitogen-activated protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35878	443	761	319	Gaps:48	88.99	318	34.98	18.37	3e-37	KOG0659 KOG0659 KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK kinase subunit CDK7 [Cell cycle control cell division chromosome partitioning Transcription Replication recombination and repair].
	gnl\|CDD\|35880	443	759	317	Gaps:56	52.60	538	33.22	19.79	1e-35	KOG0661 KOG0661 KOG0661 MAPK related serine/threonine protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35820	321	759	439	Gaps:71	71.43	560	24.50	19.25	3e-35	KOG0600 KOG0600 KOG0600 Cdc2-related protein kinase [Cell cycle control cell division chromosome partitioning].
	gnl\|CDD\|35814	450	763	314	Gaps:50	89.78	323	30.69	20.34	1e-34	KOG0594 KOG0594 KOG0594 Protein kinase PCTAIRE and related kinases [General function prediction only].
	gnl\|CDD\|35813	443	759	317	Gaps:59	71.72	396	30.63	23.59	3e-33	KOG0593 KOG0593 KOG0593 Predicted protein kinase KKIAMRE [General function prediction only].

Other analysis

Functional Gbrowse

Ortholog