GRS - Genome Report System

Sclerotinia sclerotiorum GRS

Functional annotation

SS1G_00199.1

Gene Identifier

Domain/Motif (Interproscan results)

Localization / Targeting

Blast based analysis

Analysis	Hit	start	end	length	Note	Hit coverage	Hit length	Hit pident	Hit pcons	eValue	Hit description
blastp_kegg	ssl:SS1G_00199	1	581	581	n/a	100.00	581	87.61	0.00	0.0	hypothetical protein
	bfu:BC1G_06090	1	581	581	Gaps:4	100.00	585	79.83	4.10	0.0	hypothetical protein
	fgr:FG07409.1	13	402	390	Gaps:9	81.82	473	65.37	14.47	1e-147	hypothetical protein
	pan:PODANSg8354	20	506	487	Gaps:43	83.24	543	61.28	10.62	1e-145	hypothetical protein
	cim:CIMG_06354	31	397	367	Gaps:2	64.04	570	64.66	12.60	1e-137	hypothetical protein
	afv:AFLA_048030	31	436	406	Gaps:8	75.09	538	61.88	12.87	1e-134	CDK9 putative
	ang:An17g02320	29	373	345	Gaps:2	62.03	553	65.89	12.54	1e-131	hypothetical protein
	pno:SNOG_09406	28	390	363	Gaps:6	62.85	568	63.03	13.73	1e-129	hypothetical protein
	act:ACLA_008810	31	414	384	Gaps:7	69.02	552	62.20	12.60	1e-128	protein kinase domain protein
	zma:100274390	28	399	372	Gaps:8	68.94	528	62.36	14.01	1e-128	hypothetical protein LOC100274390
blastp_uniprot_sprot	sp\|Q4I5U9\|BUR1_GIBZE	13	402	390	Gaps:9	81.82	473	65.37	14.47	1e-148	Serine/threonine-protein kinase BUR1 OS Gibberella zeae GN BUR1 PE 3 SV 1
	sp\|Q871M9\|BUR1_NEUCR	20	509	490	Gaps:21	87.16	545	57.05	12.21	1e-143	Serine/threonine-protein kinase bur-1 OS Neurospora crassa GN bur-1 PE 3 SV 1
	sp\|Q96VK3\|BUR1_EMENI	14	386	373	Gaps:6	67.83	544	62.60	13.82	1e-132	Serine/threonine-protein kinase bur1 OS Emericella nidulans GN ptkA PE 2 SV 1
	sp\|Q4WTN5\|BUR1_ASPFU	31	375	345	Gaps:2	59.14	580	66.47	13.70	1e-128	Serine/threonine-protein kinase bur1 OS Aspergillus fumigatus GN bur1 PE 3 SV 1
	sp\|Q96WV9\|CDK9_SCHPO	27	375	349	Gaps:6	59.05	591	51.86	14.33	5e-99	Serine/threonine-protein kinase cdk9 OS Schizosaccharomyces pombe GN cdk9 PE 1 SV 1
	sp\|Q6C842\|BUR1_YARLI	29	374	346	Gaps:5	48.87	706	51.30	15.94	2e-89	Serine/threonine-protein kinase BUR1 OS Yarrowia lipolytica GN BUR1 PE 3 SV 1
	sp\|Q6BV06\|BUR1_DEBHA	26	370	345	Gaps:4	57.40	608	48.42	16.05	2e-88	Serine/threonine-protein kinase BUR1 OS Debaryomyces hansenii GN BUR1 PE 3 SV 1
	sp\|Q9Y7W4\|BUR1_CANAL	35	373	339	Gaps:6	45.71	746	48.09	16.42	3e-85	Serine/threonine-protein kinase BUR1 OS Candida albicans GN CRK1 PE 3 SV 2
	sp\|Q8W4P1\|CDKC2_ARATH	33	372	340	Gaps:18	65.50	513	48.51	16.67	7e-84	Cyclin-dependent kinase C-2 OS Arabidopsis thaliana GN CDKC-2 PE 1 SV 2
	sp\|Q9LFT8\|CDKC1_ARATH	33	374	342	Gaps:22	66.93	505	49.11	16.86	1e-83	Cyclin-dependent kinase C-1 OS Arabidopsis thaliana GN CDKC-1 PE 1 SV 1
blastp_pdb	3mia_A	21	349	329	Gaps:13	91.17	351	45.00	17.50	1e-69	mol:protein length:351 Cell division protein kinase 9
	3mi9_A	21	349	329	Gaps:13	91.17	351	45.00	17.50	1e-69	mol:protein length:351 Cell division protein kinase 9
	3blr_A	21	349	329	Gaps:13	96.68	331	45.00	17.50	1e-69	mol:protein length:331 Cell division protein kinase 9
	3blq_A	21	349	329	Gaps:13	96.68	331	45.00	17.50	1e-69	mol:protein length:331 Cell division protein kinase 9
	3blh_A	21	349	329	Gaps:13	96.68	331	45.00	17.50	1e-69	mol:protein length:331 Cell division protein kinase 9
	3my1_A	21	349	329	Gaps:13	96.68	331	45.00	17.50	1e-69	mol:protein length:331 Cell division protein kinase 9
	2iw8_C	33	353	321	Gaps:32	99.01	302	42.47	19.06	3e-55	mol:protein length:302 CELL DIVISION PROTEIN KINASE 2
	2iw8_A	33	353	321	Gaps:32	99.01	302	42.47	19.06	3e-55	mol:protein length:302 CELL DIVISION PROTEIN KINASE 2
	2iw9_C	33	353	321	Gaps:32	99.01	302	42.14	19.06	9e-55	mol:protein length:302 CELL DIVISION PROTEIN KINASE 2
	2iw9_A	33	353	321	Gaps:32	99.01	302	42.14	19.06	9e-55	mol:protein length:302 CELL DIVISION PROTEIN KINASE 2
rpsblast_cdd	gnl\|CDD\|143371	31	343	313	Gaps:2	100.00	311	63.99	12.54	1e-151	cd07866 STKc_BUR1 Catalytic domain of the Serine/Threonine Kinase Fungal Cyclin-Dependent protein Kinase Bypass UAS Requirement 1 and similar proteins. Serine/Threonine Kinases (STKs) Bypass UAS Requirement 1 (BUR1) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. BUR1 also called SGV1 is a yeast Cyclin-Dependent protein Kinase (CDK) that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin.
	gnl\|CDD\|143345	40	343	304	Gaps:19	100.00	287	54.01	16.72	1e-124	cd07840 STKc_CDK9_like Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 9 (CDK9)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes yeast BUR1 C-type plant CDKs (CdkC) and similar proteins. CDK9 BUR1 and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2 and participates in regulating transcription and alternative splicing.
	gnl\|CDD\|173733	40	343	304	Gaps:22	100.00	282	48.58	15.25	1e-102	cd07829 STKc_CDK_like Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase (CDK)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDKs are partly regulated by their subcellular localization which defines substrate phosphorylation and the resulting specific function. CDK1 CDK2 CDK4 and CDK6 have well-defined functions in the cell cycle such as the regulation of the early G1 phase by CDK4 or CDK6 the G1/S phase transition by CDK2 or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes showing that some CDKs can compensate for each other. For example CDK4 can compensate for the loss of CDK6 however double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH.
	gnl\|CDD\|173741	34	343	310	Gaps:27	100.00	293	48.46	18.09	1e-101	cd07843 STKc_CDC2L1 Catalytic domain of the Serine/Threonine Kinase Cell Division Cycle 2-like 1. Serine/Threonine Kinases (STKs) Cell Division Cycle 2-like 1 (CDC2L1) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDC2L1 also called PITSLRE exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110) the major isoform associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis centrosome maturation sister chromatid cohesion and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f) p21-activated kinase (PAK1) and Ran-binding protein (RanBPM).
	gnl\|CDD\|173742	34	356	323	Gaps:19	98.38	309	45.39	18.09	3e-89	cd07845 STKc_CDK10 Catalytic domain of the Serine/Threonine Kinase Cyclin-Dependent protein Kinase 10. Serine/Threonine Kinases (STKs) Cyclin-dependent protein Kinase 10 (CDK10) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDK10 also called PISSLRE is essential for cell growth and proliferation and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen.
	gnl\|CDD\|143346	40	356	317	Gaps:26	99.66	298	45.45	15.49	2e-88	cd07841 STKc_CDK7 Catalytic domain of the Serine/Threonine Kinase Cyclin-Dependent protein Kinase 7. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 7 (CDK7) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA as present in the pre-initiation complex. Following phosphorylation the CTD dissociates from the DNA which allows transcription initiation.
	gnl\|CDD\|173754	27	343	317	Gaps:19	100.00	310	46.77	15.81	3e-88	cd07865 STKc_CDK9 Catalytic domain of the Serine/Threonine Kinase Cyclin-Dependent protein Kinase 9. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 9 (CDK9) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDK9 together with a cyclin partner (cyclin T1 T2a T2b or K) is the main component of distinct positive transcription elongation factors (P-TEFb) which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation mRNA synthesis processing export and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors.
	gnl\|CDD\|173753	37	342	306	Gaps:20	98.01	302	48.65	16.55	6e-82	cd07864 STKc_CDK12 Catalytic domain of the Serine/Threonine Kinase Cyclin-Dependent protein Kinase 12. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 12 (CDK12) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an arginine/serine-rich (RS) domain which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2 and plays roles in regulating transcription and alternative splicing.
	gnl\|CDD\|173736	39	343	305	Gaps:20	99.65	286	44.56	17.89	9e-79	cd07832 STKc_CCRK Catalytic domain of the Serine/Threonine Kinase Cell Cycle-Related Kinase. Serine/Threonine Kinases (STKs) Cell Cycle-Related Kinase (CCRK) p42 subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart a splice variant of CCRK with a different C-terminal half is expressed this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure.
	gnl\|CDD\|143333	40	343	304	Gaps:21	100.00	283	45.58	16.61	8e-78	cd05118 STKc_CMGC Catalytic domain of CMGC family Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) CMGC family catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs) Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs) c-Jun N-terminal kinases (JNKs) and p38 and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation.
rpsblast_kog	gnl\|CDD\|35820	31	475	445	Gaps:50	80.54	560	40.58	12.42	1e-107	KOG0600 KOG0600 KOG0600 Cdc2-related protein kinase [Cell cycle control cell division chromosome partitioning].
	gnl\|CDD\|35882	27	384	358	Gaps:21	81.38	419	42.82	17.89	3e-89	KOG0663 KOG0663 KOG0663 Protein kinase PITSLRE and related kinases [General function prediction only].
	gnl\|CDD\|35878	40	377	338	Gaps:29	97.17	318	43.04	16.83	2e-77	KOG0659 KOG0659 KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK kinase subunit CDK7 [Cell cycle control cell division chromosome partitioning Transcription Replication recombination and repair].
	gnl\|CDD\|35888	28	350	323	Gaps:16	84.84	376	46.71	15.05	5e-76	KOG0669 KOG0669 KOG0669 Cyclin T-dependent kinase CDK9 [Cell cycle control cell division chromosome partitioning].
	gnl\|CDD\|35814	35	350	316	Gaps:19	94.43	323	42.95	16.72	2e-72	KOG0594 KOG0594 KOG0594 Protein kinase PCTAIRE and related kinases [General function prediction only].
	gnl\|CDD\|35880	40	379	340	Gaps:32	59.85	538	36.96	19.88	3e-60	KOG0661 KOG0661 KOG0661 MAPK related serine/threonine protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35881	39	349	311	Gaps:23	99.32	292	41.03	20.00	4e-56	KOG0662 KOG0662 KOG0662 Cyclin-dependent kinase CDK5 [Intracellular trafficking secretion and vesicular transport Signal transduction mechanisms].
	gnl\|CDD\|35879	40	343	304	Gaps:18	80.78	359	38.62	17.24	4e-56	KOG0660 KOG0660 KOG0660 Mitogen-activated protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35813	40	345	306	Gaps:24	72.22	396	37.41	18.88	2e-55	KOG0593 KOG0593 KOG0593 Predicted protein kinase KKIAMRE [General function prediction only].
	gnl\|CDD\|35885	40	436	397	Gaps:64	94.29	438	31.72	17.19	9e-55	KOG0666 KOG0666 KOG0666 Cyclin C-dependent kinase CDK8 [Transcription].

Other analysis

Functional Gbrowse

Ortholog