GRS - Genome Report System

Sclerotinia sclerotiorum GRS

Functional annotation

SS1G_00098.1

Gene Identifier

Domain/Motif (Interproscan results)

Localization / Targeting

Blast based analysis

Analysis	Hit	start	end	length	Note	Hit coverage	Hit length	Hit pident	Hit pcons	eValue	Hit description
blastp_kegg	ssl:SS1G_00098	1	842	842	n/a	100.00	842	91.09	0.00	0.0	hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	bfu:BC1G_06208	1	842	842	Gaps:53	100.00	895	82.01	1.34	0.0	hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	pan:PODANSg5502	3	840	838	Gaps:99	96.59	908	64.08	6.73	0.0	hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	fgr:FG05418.1	51	842	792	Gaps:88	100.00	812	66.01	5.79	0.0	hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	ncr:NCU07872	3	833	831	Gaps:134	89.28	998	63.41	6.06	0.0	similar to protein kinase
	afv:AFLA_041740	5	842	838	Gaps:106	96.32	897	62.85	7.29	0.0	protein kinase Yak1 putative K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	afm:AFUA_4G03850	5	842	838	Gaps:119	96.31	894	62.37	7.55	0.0	protein kinase Yak1 (EC:2.7.1.-) K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	nfi:NFIA_029550	5	842	838	Gaps:119	96.31	894	62.14	7.55	0.0	protein kinase Yak1 putative K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	ang:An14g01050	1	842	842	Gaps:114	96.76	895	61.20	7.62	0.0	hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
	act:ACLA_054590	1	842	842	Gaps:112	96.76	895	60.85	8.43	0.0	protein kinase Yak1 putative K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1]
blastp_uniprot_sprot	sp\|P14680\|YAK1_YEAST	198	603	406	Gaps:48	55.51	807	51.34	18.75	1e-136	Dual specificity protein kinase YAK1 OS Saccharomyces cerevisiae GN YAK1 PE 1 SV 1
	sp\|Q9P6P3\|PPK15_SCHPO	220	597	378	Gaps:51	77.34	534	56.66	14.29	1e-134	Serine/threonine-protein kinase ppk15 OS Schizosaccharomyces pombe GN ppk15 PE 1 SV 1
	sp\|Q54QV3\|YAKA_DICDI	232	602	371	Gaps:57	28.94	1458	50.71	14.69	1e-115	Probable serine/threonine-protein kinase yakA OS Dictyostelium discoideum GN yakA PE 1 SV 1
	sp\|Q9Z188\|DYR1B_MOUSE	192	704	513	Gaps:86	86.33	629	33.70	12.52	7e-60	Dual specificity tyrosine-phosphorylation-regulated kinase 1B OS Mus musculus GN Dyrk1b PE 1 SV 3
	sp\|Q8WQL7\|MBK1_CAEEL	269	604	336	Gaps:66	41.04	882	37.85	17.40	8e-60	Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 OS Caenorhabditis elegans GN mbk-1 PE 1 SV 1
	sp\|Q9Y463\|DYR1B_HUMAN	192	704	513	Gaps:86	86.33	629	33.70	12.89	1e-59	Dual specificity tyrosine-phosphorylation-regulated kinase 1B OS Homo sapiens GN DYRK1B PE 1 SV 1
	sp\|O88850\|HIPK3_RAT	258	596	339	Gaps:56	31.15	1191	36.66	19.41	3e-58	Homeodomain-interacting protein kinase 3 OS Rattus norvegicus GN Hipk3 PE 1 SV 1
	sp\|Q9ERH7\|HIPK3_MOUSE	258	596	339	Gaps:56	31.12	1192	36.66	19.14	6e-58	Homeodomain-interacting protein kinase 3 OS Mus musculus GN Hipk3 PE 1 SV 2
	sp\|Q76NV1\|DYRK1_DICDI	272	590	319	Gaps:65	40.91	836	37.13	21.05	6e-58	Probable serine/threonine-protein kinase dyrk1 OS Dictyostelium discoideum GN dyrk1 PE 3 SV 1
	sp\|Q9V3D5\|DYRK2_DROME	266	591	326	Gaps:85	45.01	722	39.69	19.38	1e-57	Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS Drosophila melanogaster GN smi35A PE 1 SV 1
blastp_pdb	2wo6_B	299	593	295	Gaps:64	85.08	382	39.38	16.62	1e-53	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2wo6_A	299	593	295	Gaps:64	85.08	382	39.38	16.62	1e-53	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_D	299	593	295	Gaps:64	85.08	382	39.38	16.62	1e-53	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_C	299	593	295	Gaps:64	85.08	382	39.38	16.62	1e-53	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_B	299	593	295	Gaps:64	85.08	382	39.38	16.62	1e-53	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	2vx3_A	299	593	295	Gaps:64	85.08	382	39.38	16.62	1e-53	mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG
	3kvw_A	269	610	342	Gaps:90	82.52	429	37.57	16.38	2e-51	mol:protein length:429 Dual specificity tyrosine-phosphorylation-reg
	3k2l_A	269	610	342	Gaps:90	82.52	429	37.57	16.38	2e-51	mol:protein length:429 Dual specificity tyrosine-phosphorylation-reg
	2vag_A	300	595	296	Gaps:94	94.99	339	30.75	17.08	3e-28	mol:protein length:339 DUAL SPECIFICITY PROTEIN KINASE CLK1
	1z57_A	300	595	296	Gaps:94	94.99	339	30.75	17.08	3e-28	mol:protein length:339 Dual specificity protein kinase CLK1
rpsblast_cdd	gnl\|CDD\|128516	311	484	174	Gaps:44	85.25	244	32.21	15.87	1e-43	smart00220 S_TKc Serine/Threonine protein kinases catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily.
	gnl\|CDD\|173733	301	591	291	Gaps:113	100.00	282	32.27	19.86	7e-42	cd07829 STKc_CDK_like Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase (CDK)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDKs are partly regulated by their subcellular localization which defines substrate phosphorylation and the resulting specific function. CDK1 CDK2 CDK4 and CDK6 have well-defined functions in the cell cycle such as the regulation of the early G1 phase by CDK4 or CDK6 the G1/S phase transition by CDK2 or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes showing that some CDKs can compensate for each other. For example CDK4 can compensate for the loss of CDK6 however double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH.
	gnl\|CDD\|143851	301	481	181	Gaps:44	85.00	260	32.13	15.38	7e-42	pfam00069 Pkinase Protein kinase domain.
	gnl\|CDD\|173734	301	481	181	Gaps:44	78.09	283	34.39	18.55	9e-41	cd07830 STKc_MAK_like Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Male germ cell-Associated Kinase (MAK)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. This subfamily is composed of human MAK and MAK-related kinase (MRK) Saccharomyces cerevisiae Ime2p Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1 Caenorhabditis elegans dyf-5 Arabidopsis thaliana MHK and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK also called Intestinal Cell Kinase (ICK) is expressed ubiquitously with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia (ECO) suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I.
	gnl\|CDD\|128517	301	484	184	Gaps:47	99.11	225	30.04	14.35	2e-40	smart00221 STYKc Protein kinase unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.
	gnl\|CDD\|143338	299	590	292	Gaps:95	99.65	288	32.06	17.42	2e-39	cd07833 STKc_CDKL Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-dependent protein kinase like (CDKL) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs like CDKL1 and CDKL3 may be implicated in transformation and others like CDKL3 and CDKL5 are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory.
	gnl\|CDD\|143345	301	591	291	Gaps:102	100.00	287	31.36	17.42	6e-39	cd07840 STKc_CDK9_like Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 9 (CDK9)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes yeast BUR1 C-type plant CDKs (CdkC) and similar proteins. CDK9 BUR1 and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2 and participates in regulating transcription and alternative splicing.
	gnl\|CDD\|143333	301	591	291	Gaps:92	100.00	283	31.45	18.37	3e-36	cd05118 STKc_CMGC Catalytic domain of CMGC family Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) CMGC family catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs) Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs) c-Jun N-terminal kinases (JNKs) and p38 and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation.
	gnl\|CDD\|173737	300	593	294	Gaps:108	89.09	330	31.29	15.65	1e-35	cd07834 STKc_MAPK Catalytic domain of the Serine/Threonine Kinase Mitogen-Activated Protein Kinase. Serine/Threonine Kinases (STKs) Mitogen-Activated Protein Kinase (MAPK) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK) which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase a MAP4K. There are three main typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK) c-Jun N-terminal Kinase (JNK) and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4 MAPK6 NLK and ERK7.
	gnl\|CDD\|173747	300	599	300	Gaps:99	88.13	337	34.01	18.18	1e-33	cd07852 STKc_MAPK15 Catalytic domain of the Serine/Threonine Kinase Mitogen-Activated Protein Kinase 15. Serine/Threonine Kinases (STKs) Mitogen-Activated Protein Kinase 15 (MAPK15) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. MAPKs are important mediators of cellular responses to extracellular signals. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors.
rpsblast_kog	gnl\|CDD\|35886	96	672	577	Gaps:87	97.95	586	34.84	14.98	1e-105	KOG0667 KOG0667 KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase [General function prediction only].
	gnl\|CDD\|35890	241	593	353	Gaps:106	91.81	415	29.92	17.32	3e-43	KOG0671 KOG0671 KOG0671 LAMMER dual specificity kinases [Signal transduction mechanisms].
	gnl\|CDD\|35889	299	594	296	Gaps:63	42.69	752	30.84	15.89	2e-38	KOG0670 KOG0670 KOG0670 U4/U6-associated splicing factor PRP4 [RNA processing and modification].
	gnl\|CDD\|35813	299	694	396	Gaps:98	97.47	396	27.20	17.88	1e-35	KOG0593 KOG0593 KOG0593 Predicted protein kinase KKIAMRE [General function prediction only].
	gnl\|CDD\|35814	299	492	194	Gaps:54	75.54	323	30.74	18.44	9e-34	KOG0594 KOG0594 KOG0594 Protein kinase PCTAIRE and related kinases [General function prediction only].
	gnl\|CDD\|35878	300	617	318	Gaps:103	95.91	318	29.18	18.36	2e-32	KOG0659 KOG0659 KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK kinase subunit CDK7 [Cell cycle control cell division chromosome partitioning Transcription Replication recombination and repair].
	gnl\|CDD\|35880	295	705	411	Gaps:108	77.14	538	25.30	18.55	2e-30	KOG0661 KOG0661 KOG0661 MAPK related serine/threonine protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35877	300	590	291	Gaps:103	78.02	364	30.99	19.37	2e-30	KOG0658 KOG0658 KOG0658 Glycogen synthase kinase-3 [Carbohydrate transport and metabolism].
	gnl\|CDD\|35882	299	643	345	Gaps:97	81.15	419	26.18	17.35	6e-28	KOG0663 KOG0663 KOG0663 Protein kinase PITSLRE and related kinases [General function prediction only].
	gnl\|CDD\|35879	285	593	309	Gaps:104	85.52	359	29.64	17.92	8e-28	KOG0660 KOG0660 KOG0660 Mitogen-activated protein kinase [Signal transduction mechanisms].

Other analysis

Functional Gbrowse

Ortholog