Analysis | Hit | start | end | length | Note | Hit coverage | Hit length | Hit pident | Hit pcons | eValue | Hit description |
blastp_kegg | fgr:FG08545.1 | 1 | 536 | 536 | Gaps:28 | 73.92 | 717 | 73.02 | 7.55 | 0.0 | hypothetical protein K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
mgr:MGG_04958 | 1 | 520 | 520 | Gaps:21 | 73.63 | 713 | 69.33 | 8.19 | 0.0 | MG04958.4 hypothetical protein K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
bfu:BC1G_04387 | 1 | 707 | 707 | Gaps:48 | 100.00 | 632 | 78.64 | 0.00 | 0.0 | hypothetical protein K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
nfi:NFIA_081460 | 2 | 515 | 514 | Gaps:14 | 69.14 | 729 | 66.67 | 10.91 | 0.0 | vacuolar sorting-associated protein (Vps27) putative K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
ani:AN2071.2 | 2 | 540 | 539 | Gaps:20 | 72.87 | 715 | 65.83 | 10.56 | 0.0 | hypothetical protein K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
act:ACLA_089930 | 2 | 517 | 516 | Gaps:15 | 70.73 | 714 | 66.14 | 11.49 | 0.0 | vacuolar sorting-associated protein (Vps27) putative K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
afm:AFUA_2G04740 | 2 | 515 | 514 | Gaps:14 | 69.14 | 729 | 66.07 | 11.31 | 0.0 | vacuolar sorting-associated protein (Vps27) K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
ure:UREG_01157 | 2 | 516 | 515 | Gaps:33 | 74.11 | 672 | 67.67 | 11.04 | 0.0 | hypothetical protein K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
ang:An11g04400 | 2 | 503 | 502 | Gaps:13 | 69.84 | 703 | 66.40 | 11.61 | 0.0 | hypothetical protein K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
pcs:Pc12g10850 | 2 | 513 | 512 | Gaps:15 | 71.78 | 698 | 64.87 | 13.17 | 0.0 | Pc12g10850 K12182 hepatocyte growth factor-regulated tyrosine kinase substrate |
blastp_uniprot_sprot | sp|Q2GS33|VPS27_CHAGB | 2 | 560 | 559 | Gaps:32 | 74.22 | 737 | 70.75 | 8.96 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Chaetomium globosum GN VPS27 PE 3 SV 2 |
sp|Q7RZJ2|VPS27_NEUCR | 1 | 501 | 501 | Gaps:15 | 68.78 | 724 | 72.69 | 8.03 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Neurospora crassa GN vps-27 PE 3 SV 2 |
sp|A4QTV1|VPS27_MAGGR | 1 | 520 | 520 | Gaps:21 | 73.63 | 713 | 69.33 | 8.19 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Magnaporthe grisea GN VPS27 PE 3 SV 1 |
sp|A1DFP5|VPS27_NEOFI | 2 | 515 | 514 | Gaps:14 | 69.14 | 729 | 66.67 | 10.91 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) GN vps27 PE 3 SV 1 |
sp|Q0CJV3|VPS27_ASPTN | 2 | 503 | 502 | Gaps:13 | 87.95 | 556 | 67.28 | 12.07 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Aspergillus terreus (strain NIH 2624 / FGSC A1156) GN vps27 PE 3 SV 1 |
sp|Q5BBK9|VPS27_EMENI | 2 | 540 | 539 | Gaps:20 | 72.87 | 715 | 65.83 | 10.56 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Emericella nidulans GN vps27 PE 3 SV 1 |
sp|Q0U4Z8|VPS27_PHANO | 2 | 546 | 545 | Gaps:22 | 74.31 | 720 | 66.92 | 10.65 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Phaeosphaeria nodorum GN VPS27 PE 3 SV 1 |
sp|A1CEK1|VPS27_ASPCL | 2 | 517 | 516 | Gaps:15 | 70.73 | 714 | 66.14 | 11.49 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Aspergillus clavatus GN vps27 PE 3 SV 1 |
sp|Q4WHN8|VPS27_ASPFU | 2 | 515 | 514 | Gaps:14 | 69.14 | 729 | 66.07 | 11.31 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Aspergillus fumigatus GN vps27 PE 3 SV 1 |
sp|A2QWA2|VPS27_ASPNC | 2 | 503 | 502 | Gaps:13 | 69.84 | 703 | 66.40 | 11.61 | 0.0 | Vacuolar protein sorting-associated protein 27 OS Aspergillus niger (strain CBS 513.88 / FGSC A1513) GN vps27 PE 3 SV 1 |
blastp_pdb | 1dvp_A | 31 | 226 | 196 | Gaps:5 | 86.82 | 220 | 38.74 | 19.37 | 4e-33 | mol:protein length:220 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE K |
1vfy_A | 160 | 223 | 64 | n/a | 87.67 | 73 | 60.94 | 10.94 | 2e-19 | mol:protein length:73 PHOSPHATIDYLINOSITOL-3-PHOSPHATE BINDING FYVE |
1elk_B | 9 | 149 | 141 | Gaps:8 | 91.08 | 157 | 39.86 | 23.78 | 8e-19 | mol:protein length:157 TARGET OF MYB1 |
1elk_A | 9 | 149 | 141 | Gaps:8 | 91.08 | 157 | 39.86 | 23.78 | 8e-19 | mol:protein length:157 TARGET OF MYB1 |
1x5b_A | 12 | 150 | 139 | Gaps:6 | 84.05 | 163 | 29.93 | 27.01 | 4e-14 | mol:protein length:163 signal transducing adaptor molecule 2 |
3ldz_C | 6 | 149 | 144 | Gaps:8 | 100.00 | 140 | 32.14 | 22.14 | 9e-12 | mol:protein length:140 Signal transducing adapter molecule 1 |
3ldz_B | 6 | 149 | 144 | Gaps:8 | 100.00 | 140 | 32.14 | 22.14 | 9e-12 | mol:protein length:140 Signal transducing adapter molecule 1 |
3ldz_D | 6 | 149 | 144 | Gaps:8 | 100.00 | 140 | 32.14 | 22.14 | 9e-12 | mol:protein length:140 Signal transducing adapter molecule 1 |
3ldz_A | 6 | 149 | 144 | Gaps:8 | 100.00 | 140 | 32.14 | 22.14 | 9e-12 | mol:protein length:140 Signal transducing adapter molecule 1 |
2yw8_A | 167 | 231 | 65 | Gaps:5 | 80.49 | 82 | 45.45 | 12.12 | 1e-09 | mol:protein length:82 RUN and FYVE domain-containing protein 1 |
rpsblast_cdd | gnl|CDD|48664 | 8 | 151 | 144 | Gaps:6 | 100.00 | 142 | 52.82 | 16.90 | 7e-48 | cd03569 VHS_Hrs_Vps27p VHS domain family Hrs and Vps27p subfamily composed of Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and its yeast homolog Vps27p (vacuolar protein sorting). The VHS domain an essential part of Hrs/Vps27p has a superhelical structure similar to the structure of ARM (Armadillo) repeats and is present at the N-termini of proteins. Hrs also contains a FYVE (Fab1p YOTB Vac1p and EEA1) zinc finger domain C-terminal to VHS as well as two coiled-coil domains. Hrs has been proposed to play a role in at least three vesicle trafficking events: exocytosis endocytosis and endosome to lysosome trafficking. Hrs is involved in promoting rapid recycling of endocytosed signaling receptors to the plasma membrane.. |
gnl|CDD|128584 | 16 | 145 | 130 | Gaps:5 | 96.99 | 133 | 48.06 | 16.28 | 2e-36 | smart00288 VHS Domain present in VPS-27 Hrs and STAM. Unpublished observations. Domain of unknown function. |
gnl|CDD|144401 | 11 | 145 | 135 | Gaps:7 | 100.00 | 136 | 48.53 | 16.18 | 2e-35 | pfam00790 VHS VHS domain. Domain present in VPS-27 Hrs and STAM. |
gnl|CDD|48658 | 12 | 143 | 132 | Gaps:5 | 100.00 | 133 | 39.10 | 18.80 | 1e-25 | cd03561 VHS VHS domain family The VHS domain is present in Vps27 (Vacuolar Protein Sorting) Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal Transducing Adaptor Molecule). It has a superhelical structure similar to that of the ARM (Armadillo) repeats and is present at the N-termini of proteins involved in intracellular membrane trafficking. There are four general groups of VHS domain containing proteins based on their association with other domains. The first group consists of proteins of the STAM/EAST/Hbp family which has the domain composition VHS-SH3-ITAM. The second consists of proteins with a FYVE domain C-terminal to VHS. The third consists of GGA proteins with a domain composition VHS-GAT (GGA and TOM)-GAE (gamma-adaptin ear) domain. The fourth consists of proteins with a VHS domain alone or with domains other than those mentioned above. In GGA proteins VHS domains are involved in cargo recognition in trans-Golgi thereby having a general membrane targeting/cargo recognition role in vesicular trafficking.. |
gnl|CDD|144816 | 165 | 227 | 63 | Gaps:4 | 98.53 | 68 | 52.24 | 5.97 | 5e-24 | pfam01363 FYVE FYVE zinc finger. The FYVE zinc finger is named after four proteins that it has been found in: Fab1 YOTB/ZK632.12 Vac1 and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related. |
gnl|CDD|48663 | 12 | 152 | 141 | Gaps:11 | 100.00 | 144 | 32.64 | 20.83 | 9e-23 | cd03568 VHS_STAM VHS domain family STAM subfamily members include STAM (Signal Transducing Adaptor Molecule) EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively they are referred to as STAM. All STAMs have at their N-termini a VHS domain which is involved in cytokine-mediated intracellular signal transduction and has a superhelical structure similar to the structure of ARM (Armadillo) repeats followed by a SH3 (Src homology 3) domain a well-established protein-protein interaction domain. At the C-termini of most vertebrate STAMS an ITAM (Immunoreceptor Tyrosine-based Activation) motif is present which mediates the binding of HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) in endocytic and exocytic machineries.. |
gnl|CDD|48661 | 16 | 149 | 134 | Gaps:6 | 96.45 | 141 | 41.18 | 18.38 | 3e-22 | cd03565 VHS_Tom1 VHS domain family Tom1 subfamily The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of proteins. It is a right-handed superhelix of eight alpha helices. The VHS domain has been found in a number of proteins some of which have been implicated in intracellular trafficking and sorting. The VHS domain of the Tom1 protein is essential for the negative regulation of Interleukin-1 and Tumor Necrosis Factor-induced signaling pathways.. |
gnl|CDD|128378 | 165 | 223 | 59 | Gaps:3 | 91.18 | 68 | 54.84 | 8.06 | 2e-21 | smart00064 FYVE Protein present in Fab1 YOTB Vac1 and EEA1. The FYVE zinc finger is named after four proteins where it was first found: Fab1 YOTB/ZK632.12 Vac1 and EEA1. The FYVE finger has been shown to bind two Zn2+ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. The FYVE finger is structurally related to the PH D finger and the RI NG finger. Many members of this family also include two histidines in a motif R+HHC+XCG where + represents a charged residue and X any residue. The FYVE finger functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P) which is prominent on endosomes. The R+HHC+XCG motif is critical for PI3P binding. |
gnl|CDD|28947 | 169 | 223 | 55 | n/a | 96.49 | 57 | 52.73 | 14.55 | 5e-19 | cd00065 FYVE FYVE domain Zinc-binding domain targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate PI3P present in Fab1 YOTB Vac1 and EEA1 . |
gnl|CDD|48657 | 16 | 122 | 107 | Gaps:3 | 95.65 | 115 | 40.91 | 17.27 | 2e-16 | cd00197 VHS_ENTH_ANTH VHS ENTH and ANTH domain superfamily composed of proteins containing a VHS ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting) Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal Transducing Adaptor Molecule). It is located at the N-termini of proteins involved in intracellular membrane trafficking. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar yet unique module referred to as an AP180 N-terminal homology (ANTH) domain. VHS ENTH and ANTH domains are structurally similar and are composed of a superhelix of eight alpha helices. ENTH adnd ANTH (E/ANTH) domains bind both inositol phospholipids and proteins and contribute to the nucleation and formation of clathrin coats on membranes. ENTH domains also function in the development of membrane curvature through lipid remodeling during the formation of clathrin-coated vesicles. E/ANTH domain-bearing proteins have recently been shown to function with adaptor protein-1 and GGA adaptors at the trans-Golgi network which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding.. |
rpsblast_kog | gnl|CDD|37029 | 5 | 672 | 668 | Gaps:56 | 99.05 | 634 | 28.50 | 15.45 | 5e-65 | KOG1818 KOG1818 KOG1818 Membrane trafficking and cell signaling protein HRS contains VHS and FYVE domains [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport]. |
gnl|CDD|36303 | 11 | 165 | 155 | Gaps:6 | 32.98 | 470 | 39.35 | 19.35 | 6e-22 | KOG1087 KOG1087 KOG1087 Cytosolic sorting protein GGA2/TOM1 [Intracellular trafficking secretion and vesicular transport]. |
gnl|CDD|37410 | 4 | 592 | 589 | Gaps:70 | 96.75 | 462 | 24.38 | 19.91 | 8e-16 | KOG2199 KOG2199 KOG2199 Signal transducing adaptor protein STAM/STAM2 [Signal transduction mechanisms]. |
gnl|CDD|36940 | 152 | 270 | 119 | Gaps:11 | 44.44 | 288 | 24.22 | 16.41 | 2e-12 | KOG1729 KOG1729 KOG1729 FYVE finger containing protein [General function prediction only]. |
gnl|CDD|37030 | 123 | 218 | 96 | Gaps:10 | 10.71 | 990 | 30.19 | 17.92 | 4e-10 | KOG1819 KOG1819 KOG1819 FYVE finger-containing proteins [General function prediction only]. |
gnl|CDD|36623 | 165 | 283 | 119 | Gaps:29 | 27.72 | 404 | 32.14 | 9.82 | 6e-10 | KOG1409 KOG1409 KOG1409 Uncharacterized conserved protein contains WD40 repeats and FYVE domains [Function unknown]. |
gnl|CDD|36302 | 12 | 172 | 161 | Gaps:9 | 26.94 | 594 | 28.75 | 18.75 | 7e-08 | KOG1086 KOG1086 KOG1086 Cytosolic sorting protein/ADP-ribosylation factor effector GGA [Intracellular trafficking secretion and vesicular transport]. |
gnl|CDD|37196 | 540 | 674 | 135 | Gaps:24 | 12.97 | 887 | 31.30 | 5.22 | 2e-07 | KOG1985 KOG1985 KOG1985 Vesicle coat complex COPII subunit SEC24/subunit SFB2 [Intracellular trafficking secretion and vesicular transport]. |
gnl|CDD|38804 | 461 | 684 | 224 | Gaps:26 | 9.19 | 2220 | 17.65 | 11.76 | 5e-07 | KOG3598 KOG3598 KOG3598 Thyroid hormone receptor-associated protein complex subunit TRAP230 [Transcription]. |