Analysis | Hit | start | end | length | Note | Hit coverage | Hit length | Hit pident | Hit pcons | eValue | Hit description |
blastp_kegg | bfu:BC1G_06208 | 27 | 921 | 895 | n/a | 93.30 | 895 | 92.10 | 0.00 | 0.0 | hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
ssl:SS1G_00098 | 27 | 921 | 895 | Gaps:43 | 94.06 | 842 | 89.27 | 1.64 | 0.0 | hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
pan:PODANSg5502 | 1 | 921 | 921 | Gaps:54 | 88.22 | 908 | 73.78 | 6.37 | 0.0 | hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
ncr:NCU07872 | 3 | 912 | 910 | Gaps:58 | 80.46 | 998 | 71.48 | 5.73 | 0.0 | similar to protein kinase |
fgr:FG05418.1 | 77 | 921 | 845 | Gaps:22 | 89.78 | 812 | 76.27 | 6.31 | 0.0 | hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
afv:AFLA_041740 | 1 | 921 | 921 | Gaps:43 | 91.53 | 897 | 68.33 | 7.43 | 0.0 | protein kinase Yak1 putative K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
afm:AFUA_4G03850 | 3 | 921 | 919 | Gaps:53 | 91.39 | 894 | 68.18 | 7.59 | 0.0 | protein kinase Yak1 (EC:2.7.1.-) K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
nfi:NFIA_029550 | 3 | 921 | 919 | Gaps:45 | 91.39 | 894 | 67.81 | 7.59 | 0.0 | protein kinase Yak1 putative K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
act:ACLA_054590 | 3 | 921 | 919 | Gaps:46 | 91.40 | 895 | 66.99 | 8.44 | 0.0 | protein kinase Yak1 putative K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
ang:An14g01050 | 1 | 921 | 921 | Gaps:51 | 92.07 | 895 | 67.60 | 7.04 | 0.0 | hypothetical protein K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase [EC:2.7.12.1] |
blastp_uniprot_sprot | sp|P14680|YAK1_YEAST | 224 | 672 | 449 | Gaps:5 | 55.51 | 807 | 56.70 | 18.97 | 1e-156 | Dual specificity protein kinase YAK1 OS Saccharomyces cerevisiae GN YAK1 PE 1 SV 1 |
sp|Q9P6P3|PPK15_SCHPO | 246 | 666 | 421 | Gaps:8 | 77.34 | 534 | 62.23 | 15.01 | 1e-153 | Serine/threonine-protein kinase ppk15 OS Schizosaccharomyces pombe GN ppk15 PE 1 SV 1 |
sp|Q54QV3|YAKA_DICDI | 258 | 671 | 414 | Gaps:14 | 28.94 | 1458 | 56.40 | 16.11 | 1e-136 | Probable serine/threonine-protein kinase yakA OS Dictyostelium discoideum GN yakA PE 1 SV 1 |
sp|Q9Z188|DYR1B_MOUSE | 218 | 689 | 472 | Gaps:50 | 72.18 | 629 | 41.63 | 14.54 | 1e-76 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B OS Mus musculus GN Dyrk1b PE 1 SV 3 |
sp|Q9Y463|DYR1B_HUMAN | 218 | 689 | 472 | Gaps:50 | 72.18 | 629 | 40.97 | 14.98 | 7e-76 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B OS Homo sapiens GN DYRK1B PE 1 SV 1 |
sp|Q8WQL7|MBK1_CAEEL | 295 | 674 | 380 | Gaps:25 | 41.16 | 882 | 42.70 | 19.56 | 1e-75 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 OS Caenorhabditis elegans GN mbk-1 PE 1 SV 1 |
sp|A8X4H1|MBK1_CAEBR | 295 | 648 | 354 | Gaps:25 | 37.28 | 904 | 43.92 | 19.58 | 7e-73 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 OS Caenorhabditis briggsae GN mbk-1 PE 3 SV 2 |
sp|O88850|HIPK3_RAT | 284 | 665 | 382 | Gaps:17 | 31.15 | 1191 | 40.43 | 21.02 | 7e-72 | Homeodomain-interacting protein kinase 3 OS Rattus norvegicus GN Hipk3 PE 1 SV 1 |
sp|Q9ERH7|HIPK3_MOUSE | 284 | 665 | 382 | Gaps:17 | 31.12 | 1192 | 40.43 | 20.75 | 1e-71 | Homeodomain-interacting protein kinase 3 OS Mus musculus GN Hipk3 PE 1 SV 2 |
sp|Q9V3D5|DYRK2_DROME | 292 | 660 | 369 | Gaps:44 | 45.01 | 722 | 44.31 | 22.15 | 1e-71 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS Drosophila melanogaster GN smi35A PE 1 SV 1 |
blastp_pdb | 2wo6_B | 325 | 662 | 338 | Gaps:23 | 85.08 | 382 | 43.69 | 19.08 | 8e-67 | mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG |
2wo6_A | 325 | 662 | 338 | Gaps:23 | 85.08 | 382 | 43.69 | 19.08 | 8e-67 | mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG |
2vx3_D | 325 | 662 | 338 | Gaps:23 | 85.08 | 382 | 43.69 | 19.08 | 8e-67 | mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG |
2vx3_C | 325 | 662 | 338 | Gaps:23 | 85.08 | 382 | 43.69 | 19.08 | 8e-67 | mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG |
2vx3_B | 325 | 662 | 338 | Gaps:23 | 85.08 | 382 | 43.69 | 19.08 | 8e-67 | mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG |
2vx3_A | 325 | 662 | 338 | Gaps:23 | 85.08 | 382 | 43.69 | 19.08 | 8e-67 | mol:protein length:382 DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REG |
3kvw_A | 295 | 663 | 369 | Gaps:45 | 79.72 | 429 | 41.81 | 19.01 | 9e-66 | mol:protein length:429 Dual specificity tyrosine-phosphorylation-reg |
3k2l_A | 295 | 663 | 369 | Gaps:45 | 79.72 | 429 | 41.81 | 19.01 | 9e-66 | mol:protein length:429 Dual specificity tyrosine-phosphorylation-reg |
2vag_A | 326 | 664 | 339 | Gaps:53 | 94.99 | 339 | 32.92 | 19.57 | 1e-38 | mol:protein length:339 DUAL SPECIFICITY PROTEIN KINASE CLK1 |
1z57_A | 326 | 664 | 339 | Gaps:53 | 94.99 | 339 | 32.92 | 19.57 | 1e-38 | mol:protein length:339 Dual specificity protein kinase CLK1 |
rpsblast_cdd | gnl|CDD|128516 | 337 | 553 | 217 | Gaps:21 | 85.25 | 244 | 37.50 | 19.71 | 2e-55 | smart00220 S_TKc Serine/Threonine protein kinases catalytic domain. Phosphotransferases. Serine or threonine-specific kinase subfamily. |
gnl|CDD|173734 | 327 | 550 | 224 | Gaps:9 | 78.09 | 283 | 40.27 | 22.62 | 7e-55 | cd07830 STKc_MAK_like Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Male germ cell-Associated Kinase (MAK)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. This subfamily is composed of human MAK and MAK-related kinase (MRK) Saccharomyces cerevisiae Ime2p Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1 Caenorhabditis elegans dyf-5 Arabidopsis thaliana MHK and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK also called Intestinal Cell Kinase (ICK) is expressed ubiquitously with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia (ECO) suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. |
gnl|CDD|128517 | 327 | 553 | 227 | Gaps:22 | 99.11 | 225 | 33.18 | 18.83 | 1e-51 | smart00221 STYKc Protein kinase unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. |
gnl|CDD|143851 | 327 | 550 | 224 | Gaps:21 | 85.00 | 260 | 36.65 | 19.46 | 2e-51 | pfam00069 Pkinase Protein kinase domain. |
gnl|CDD|173733 | 327 | 660 | 334 | Gaps:88 | 100.00 | 282 | 35.11 | 22.70 | 5e-51 | cd07829 STKc_CDK_like Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase (CDK)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. CDKs are partly regulated by their subcellular localization which defines substrate phosphorylation and the resulting specific function. CDK1 CDK2 CDK4 and CDK6 have well-defined functions in the cell cycle such as the regulation of the early G1 phase by CDK4 or CDK6 the G1/S phase transition by CDK2 or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes showing that some CDKs can compensate for each other. For example CDK4 can compensate for the loss of CDK6 however double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. |
gnl|CDD|143338 | 325 | 659 | 335 | Gaps:68 | 99.65 | 288 | 35.54 | 20.91 | 1e-48 | cd07833 STKc_CDKL Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-dependent protein kinase like (CDKL) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs like CDKL1 and CDKL3 may be implicated in transformation and others like CDKL3 and CDKL5 are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. |
gnl|CDD|143333 | 327 | 660 | 334 | Gaps:65 | 100.00 | 283 | 36.40 | 20.85 | 5e-48 | cd05118 STKc_CMGC Catalytic domain of CMGC family Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) CMGC family catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs) Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs) c-Jun N-terminal kinases (JNKs) and p38 and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation. |
gnl|CDD|173623 | 333 | 521 | 189 | Gaps:16 | 86.98 | 215 | 35.83 | 21.39 | 2e-44 | cd00180 PKc Catalytic domain of Protein Kinases. Protein Kinases (PKs) catalytic (c) domain. PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases aminoglycoside phosphotransferase choline kinase phosphoinositide 3-kinase (PI3K) and actin-fragmin kinase. PKs make up a large family of serine/threonine kinases protein tyrosine kinases (PTKs) and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation about 95% occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins such as enzymes and membrane channels are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase which in turn may act on other kinases this sequential action transmits a signal from the cell surface to target proteins which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and 550 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate tissue distribution and cellular localization. PKs regulate many cellular processes including proliferation division differentiation motility survival metabolism cell-cycle progression cytoskeletal rearrangement immunity and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. |
gnl|CDD|143345 | 327 | 660 | 334 | Gaps:71 | 100.00 | 287 | 32.75 | 22.30 | 2e-43 | cd07840 STKc_CDK9_like Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Cyclin-Dependent protein Kinase 9 (CDK9)-like subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes yeast BUR1 C-type plant CDKs (CdkC) and similar proteins. CDK9 BUR1 and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2 and participates in regulating transcription and alternative splicing. |
gnl|CDD|173736 | 326 | 661 | 336 | Gaps:68 | 100.00 | 286 | 32.52 | 22.38 | 3e-43 | cd07832 STKc_CCRK Catalytic domain of the Serine/Threonine Kinase Cell Cycle-Related Kinase. Serine/Threonine Kinases (STKs) Cell Cycle-Related Kinase (CCRK) p42 subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart a splice variant of CCRK with a different C-terminal half is expressed this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. |
rpsblast_kog | gnl|CDD|35886 | 120 | 746 | 627 | Gaps:70 | 95.05 | 586 | 40.04 | 16.34 | 1e-127 | KOG0667 KOG0667 KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase [General function prediction only]. |
gnl|CDD|35889 | 325 | 663 | 339 | Gaps:22 | 42.69 | 752 | 37.07 | 17.76 | 3e-57 | KOG0670 KOG0670 KOG0670 U4/U6-associated splicing factor PRP4 [RNA processing and modification]. |
gnl|CDD|35890 | 267 | 662 | 396 | Gaps:65 | 91.81 | 415 | 32.02 | 21.52 | 5e-57 | KOG0671 KOG0671 KOG0671 LAMMER dual specificity kinases [Signal transduction mechanisms]. |
gnl|CDD|35813 | 325 | 753 | 429 | Gaps:62 | 96.21 | 396 | 27.30 | 21.52 | 1e-42 | KOG0593 KOG0593 KOG0593 Predicted protein kinase KKIAMRE [General function prediction only]. |
gnl|CDD|35878 | 326 | 686 | 361 | Gaps:76 | 95.91 | 318 | 32.79 | 20.00 | 1e-42 | KOG0659 KOG0659 KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK kinase subunit CDK7 [Cell cycle control cell division chromosome partitioning Transcription Replication recombination and repair]. |
gnl|CDD|35880 | 321 | 784 | 464 | Gaps:69 | 77.14 | 538 | 28.92 | 20.96 | 8e-42 | KOG0661 KOG0661 KOG0661 MAPK related serine/threonine protein kinase [Signal transduction mechanisms]. |
gnl|CDD|35814 | 325 | 561 | 237 | Gaps:25 | 75.54 | 323 | 35.66 | 20.90 | 1e-39 | KOG0594 KOG0594 KOG0594 Protein kinase PCTAIRE and related kinases [General function prediction only]. |
gnl|CDD|35877 | 326 | 548 | 223 | Gaps:27 | 60.99 | 364 | 35.14 | 22.97 | 3e-38 | KOG0658 KOG0658 KOG0658 Glycogen synthase kinase-3 [Carbohydrate transport and metabolism]. |
gnl|CDD|35879 | 311 | 662 | 352 | Gaps:67 | 85.52 | 359 | 32.57 | 22.15 | 4e-34 | KOG0660 KOG0660 KOG0660 Mitogen-activated protein kinase [Signal transduction mechanisms]. |
gnl|CDD|35820 | 321 | 834 | 514 | Gaps:88 | 79.64 | 560 | 22.65 | 22.42 | 2e-33 | KOG0600 KOG0600 KOG0600 Cdc2-related protein kinase [Cell cycle control cell division chromosome partitioning]. |