GRS - Genome Report System

Botrytis cinerea B0510 GRS

Functional annotation

BC1G_08982.1

>BC1G_08982.1 | 2369 aa 
MSQLLKKPVKIALIQLASGSDKSQNLAHAREKVLEAASAGAKIIVLPECFNSPYGTQYFPKYADTLLPSPPTSEQSPSFHALSAMAAETKTYLVGGSIPEYSPTTKNHYNTSLTFSPSGELLATHRKVHLFDIDIPGKITFRESEVLSPGNHVTMIDLPEYGKIAVAICYDVRFPELAMIAARKGCFALIYPGAFNTTTGPLHWRLQGQARAMDNQIYVALCSPARDETASYHAWGHSLVVDPMAQVLVEAEEKEEIVYAELNGEKIEETRKGIPIQTQRRLPHIQRPMDSPSVGPAEVSVIGRRRRSSAQSTSFEYPTNCRVEEDILSRIRALVLSRNTSRPPRTPHPSDERNPPRYENRAFGSLDDYIGPQKPARGTRSDSGFLGVEPYACNFRGSDGSMDIDVPPLQKTRQNSNPSVSPKRTSRLRGSSSANDLRIDGGATDVDPSIDSKLLKSTSTPKKKYFTLPRLVVRDIKEPDKPSGTKIAVGSCMPPLKNIYHKVPTEDTSDQDVNSTCSHCEQPANPKCPEPAVADAKLSRFSTLPQSPPEEVKGQPEIVCSPTCPPNCQEHYVYHPLPNTMSTGDQLKIDIRLAEEEIANLDFALNDIKAHEALGQPLGYKSKSRESRVQDDMKSESSFRTATITNPRDTEGSPPPTRGSSVSSVDAFPHVLTSEMAVDELVPGPLSSAVVTNFSLPGPKAKGSVSISKDETRQAVPPKRGRSPSIGSIRAKPKTPSLLSGASRNSVRHSLLKTSLATGTPVDTGLPVSPVLTSVTLASNSVPERVASPQQIATPSLGTKIPLEPILADLAAAASLSSMNPKNEKDGDANSSEMPSHDRFVIEEISPSCIKLGYIDKSSPSVPLLTAVVTVPKKPEPAENIKDTSSNKPNIPERNEARTKVLTDQKSVEEIQRQDASEAFPSIDPLNASYWGFVPAVRDAVQDAVKVAVRNAIQDIVVPPGIEKAEASDAYRMLVADSLAEAAKTADEYLRRDSLWTQVPESAPDSAPESYFDDKSAQISRIDFSPTREEVPKSQVLAANSGEMEDIPLGSTSGNRRHESSKATTTIYDAIPPRDSSKNRAQVSKNGTADASATSSKKDDSRRRGSNGALMSVADSTNNTTSDDRTMNSKNTVHWLKELLSSNDAYAPRLTALPPRSRRAEALSGSSGRQRSFTAPAVPVAEIFLGATPSPLETKPKITFADPKDKGAAVAATFTRTINDLEKLLNEALSIAKQAAERNDDNSVPNILNNAAAILKGGRQFMDCGKTSFSQKARRKPRAEVLSSVESLPSAHESARSYSGTSTEGNTDDDEFTDDEIITQAPASDIVIEAPVERQEYLKIIDPSLDIPDQAFRGRERSATWDSSRALHALDIPGDPKKQRALTQRHSIPRQSTAGVSPSSESNRVHSNPVYGNLEKPSRTTTSGGFGWQDISEHPTIYQSPSLLRSQSGEEVRPGKQLYEEDTTTLAKLPVTTLRGKSSVSNSLDGSHPSETVDFQTGFHHEYIMQHVEGRGGLAQSQPRSRLRSRAQTQYRQVAQGGEIGEAREGSGGEEDRDKVVELREQRPALNRDGSNRSANINTNMSHHFFNLKGKRHVSLKEHKGFSLARTHKRRPIARDWSPSRKRFTAVITCFSTFLIGLVIGIYAGEVPSIQYSIVDLHHFTVLGNVFFFIGLAIPTTFFWPLPLLHGRKPYILGSMSLAMPLLFPQALAVGATRNPELAGWRIGLLLSRSFMGFILGFANMNFLSTLMDLFGASLQSANPHQEYVDESDVRRHGGGMGLWLGIWTWCYVGSIGVGFLLGAIIINFLTPAWGFYISVAILALVLVLNVVAPEVRRSAFRRSVTEVRKDDQVSRRLAKGEVKMHRVHTGPKWWGEEFHHGVLLTKSMMRQPGFLVLAFYQAWIYGQIILIMILLGSLTSKYYKFKSPYVGASVASIPLGALLSVPFQKAGVFSRERKEGIESDDDTLKKKKISLSSHFVRRSIFVILLPFVGLAYTLSSTGPPVPFMLPIIWAAAIGFLSNLAVAECNGIIMETFDTSDLQPGMTGRPRSGSKSGKVTNYSCFPRVCAAFGITQGIGFCIAAMASGIGGVAQRHLGQQAATGVMCGVLLILSVLLICVLARFQDVQIIPESKTGEMERYQALKREQYIQGNTGNGVDDEWRPIIIGNPTHIMRRMSVLEMGSMTRWTEIRNKNRLVDEKSLEARHANLNTLVQVEKKLKEKRKHVVETVRRSLSGSRDGGDDAREYSYEEKVTTRNLVPGGGVGGYGDERMDFRDDRMGKFMGNSGRESRGGDVRERVVQEKEVTTTQRGQPILLGELSGLTEIDLGVPEAGNAEVEEQGEIDKGRRSRGETRDGARDRDRDRDREGYIRG

Domain/Motif (Interproscan results)

Localization / Targeting

Blast based analysis

Analysis	Hit	start	end	length	Note	Hit coverage	Hit length	Hit pident	Hit pcons	eValue	Hit description
blastp_kegg	bfu:BC1G_08982	1	2346	2346	n/a	99.03	2369	94.67	0.00	0.0	hypothetical protein
	ssl:SS1G_10280	289	2346	2058	Gaps:21	97.96	2106	78.19	7.03	0.0	hypothetical protein
	pan:PODANSg7976	1586	2208	623	Gaps:10	37.65	1676	58.64	15.06	0.0	hypothetical protein
	fgr:FG10094.1	1584	2233	650	Gaps:13	49.70	1314	51.61	15.93	0.0	hypothetical protein
	pno:SNOG_14179	1612	2202	591	Gaps:16	65.68	912	49.92	17.86	1e-168	hypothetical protein
	mgr:MGG_13812	1586	2211	626	Gaps:95	59.02	937	52.26	17.72	1e-160	MG04497.4 MG04498.4 hypothetical protein
	ssl:SS1G_10281	1	282	282	n/a	94.63	298	90.43	1.77	1e-150	hypothetical protein
	afm:AFUA_6G13230	1	282	282	n/a	96.58	292	72.34	11.35	1e-123	nitrilase family protein (Nit3)
	act:ACLA_086490	1	282	282	n/a	96.58	292	71.63	10.99	1e-121	nitrilase family protein (Nit3) putative
	nfi:NFIA_059160	1	282	282	n/a	96.58	292	71.63	10.99	1e-121	nitrilase family protein (Nit3) putative
blastp_uniprot_sprot	sp\|Q10166\|YAUB_SCHPO	7	282	276	Gaps:9	82.92	322	57.30	14.23	3e-86	UPF0012 hydrolase C26A3.11 OS Schizosaccharomyces pombe GN SPAC26A3.11 PE 2 SV 1
	sp\|P49954\|NIT3_YEAST	2	282	281	Gaps:8	95.88	291	51.25	14.70	1e-75	Probable hydrolase NIT3 OS Saccharomyces cerevisiae GN NIT3 PE 1 SV 1
	sp\|Q497B0\|NIT2_RAT	10	281	272	Gaps:11	94.57	276	54.41	11.88	1e-73	Omega-amidase NIT2 OS Rattus norvegicus GN Nit2 PE 1 SV 1
	sp\|Q9JHW2\|NIT2_MOUSE	10	281	272	Gaps:11	94.57	276	54.79	11.49	3e-73	Omega-amidase NIT2 OS Mus musculus GN Nit2 PE 1 SV 1
	sp\|Q2T9R6\|NIT2_BOVIN	10	281	272	Gaps:11	94.57	276	53.26	14.18	9e-73	Omega-amidase NIT2 OS Bos taurus GN NIT2 PE 2 SV 1
	sp\|Q4VBV9\|NIT2_DANRE	10	281	272	Gaps:11	94.22	277	53.26	13.03	3e-72	Omega-amidase NIT2 OS Danio rerio GN nit2 PE 2 SV 1
	sp\|Q6INI7\|NIT2B_XENLA	10	281	272	Gaps:11	94.57	276	53.26	12.64	4e-72	Omega-amidase NIT2-B OS Xenopus laevis GN nit2b PE 2 SV 1
	sp\|Q28IE5\|NIT2_XENTR	10	281	272	Gaps:11	94.57	276	52.11	14.56	7e-72	Omega-amidase NIT2 OS Xenopus tropicalis GN nit2 PE 2 SV 1
	sp\|Q9NQR4\|NIT2_HUMAN	10	281	272	Gaps:11	94.57	276	52.49	14.94	3e-71	Omega-amidase NIT2 OS Homo sapiens GN NIT2 PE 1 SV 1
	sp\|Q6IR61\|NIT2A_XENLA	10	276	267	Gaps:11	92.75	276	53.12	11.72	4e-70	Omega-amidase NIT2-A OS Xenopus laevis GN nit2a PE 2 SV 1
blastp_pdb	1f89_B	2	282	281	Gaps:8	95.88	291	51.25	14.70	2e-76	mol:protein length:291 32.5 KDA PROTEIN YLR351C
	1f89_A	2	282	281	Gaps:8	95.88	291	51.25	14.70	2e-76	mol:protein length:291 32.5 KDA PROTEIN YLR351C
	2w1v_B	10	281	272	Gaps:11	94.57	276	54.79	11.49	5e-74	mol:protein length:276 NITRILASE HOMOLOG 2
	2w1v_A	10	281	272	Gaps:11	94.57	276	54.79	11.49	5e-74	mol:protein length:276 NITRILASE HOMOLOG 2
	1ems_B	11	281	271	Gaps:10	60.23	440	30.57	17.36	1e-28	mol:protein length:440 NIT-FRAGILE HISTIDINE TRIAD FUSION PROTEIN
	1ems_A	11	281	271	Gaps:10	60.23	440	30.57	17.36	1e-28	mol:protein length:440 NIT-FRAGILE HISTIDINE TRIAD FUSION PROTEIN
	1j31_D	9	243	235	Gaps:25	81.68	262	29.44	20.56	7e-12	mol:protein length:262 Hypothetical protein PH0642
	1j31_C	9	243	235	Gaps:25	81.68	262	29.44	20.56	7e-12	mol:protein length:262 Hypothetical protein PH0642
	1j31_B	9	243	235	Gaps:25	81.68	262	29.44	20.56	7e-12	mol:protein length:262 Hypothetical protein PH0642
	1j31_A	9	243	235	Gaps:25	81.68	262	29.44	20.56	7e-12	mol:protein length:262 Hypothetical protein PH0642
rpsblast_cdd	gnl\|CDD\|143596	10	281	272	Gaps:7	100.00	265	49.81	16.60	1e-115	cd07572 nit Nit1 Nit 2 and related proteins and the Nit1-like domain of NitFhit (class 10 nitrilases). This subgroup includes mammalian Nit1 and Nit2 the Nit1-like domain of the invertebrate NitFhit and various uncharacterized bacterial and archaeal Nit-like proteins. Nit1 and Nit2 are candidate tumor suppressor proteins. In NitFhit the Nit1-like domain is encoded as a fusion protein with the non-homologous tumor suppressor fragile histidine triad (Fhit). Mammalian Nit1 and Fhit may affect distinct signal pathways and both may participate in DNA damage-induced apoptosis. Nit1 is a negative regulator in T cells. Overexpression of Nit2 in HeLa cells leads to a suppression of cell growth through cell cycle arrest in G2. These Nit proteins and the Nit1-like domain of NitFhit belong to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13) this subgroup corresponds to class 10.
	gnl\|CDD\|143607	10	281	272	Gaps:37	100.00	253	39.53	15.81	1e-57	cd07583 nitrilase_5 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes the basic building block of which is a homodimer.
	gnl\|CDD\|143587	11	281	271	Gaps:20	100.00	253	39.13	14.62	3e-57	cd07197 nitrilase Nitrilase superfamily including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds it includes nitrilases cyanide dihydratases aliphatic amidases N-terminal amidases beta-ureidopropionases biotinidases pantotheinase N-carbamyl-D-amino acid amidohydrolases the glutaminase domain of glutamine-dependent NAD+ synthetase apolipoprotein N-acyltransferases and N-carbamoylputrescine amidohydrolases among others. These enzymes depend on a Glu-Lys-Cys catalytic triad and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes the basic building block of which is a homodimer. These oligomers include dimers tetramers hexamers octamers tetradecamers octadecamers as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism in detoxifying small molecules in the synthesis of signaling molecules and in the post-translational modification of proteins. They are used industrially as biocatalysts in the fine chemical and pharmaceutical industry in cyanide remediation and in the treatment of toxic effluent. This superfamily has been classified previously in the literature based on global and structure-based sequence analysis into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative the plasmid-borne TraB family has not been included in the hierarchy.
	gnl\|CDD\|30737	7	281	275	Gaps:18	95.99	274	34.22	20.91	2e-53	COG0388 COG0388 Predicted amidohydrolase [General function prediction only].
	gnl\|CDD\|143605	11	281	271	Gaps:30	100.00	255	36.47	19.22	2e-49	cd07581 nitrilase_3 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes the basic building block of which is a homodimer.
	gnl\|CDD\|166439	7	281	275	Gaps:11	95.07	284	33.70	20.74	2e-42	PLN02798 PLN02798 nitrilase.
	gnl\|CDD\|143597	9	281	273	Gaps:42	96.83	284	33.45	16.00	3e-41	cd07573 CPA N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases). CPA (EC 3.5.1.53 also known as N-carbamoylputrescine amidase and carbamoylputrescine hydrolase) converts N-carbamoylputrescine to putrescine a step in polyamine biosynthesis in plants and bacteria. This subgroup includes Arabidopsis thaliana CPA also known as nitrilase-like 1 (NLP1) and Pseudomonas aeruginosa AguB. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13) this subgroup corresponds to class 11. Members of this superfamily generally form homomeric complexes the basic building block of which is a homodimer P. aeruginosa AugB is a homohexamer Arabidopsis thaliana NLP1 is a homooctomer.
	gnl\|CDD\|144405	10	194	185	Gaps:17	100.00	172	37.79	12.21	2e-34	pfam00795 CN_hydrolase Carbon-nitrogen hydrolase. This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1 Aliphatic amidase EC:3.5.1.4 Biotidinase EC:3.5.1.12 Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad and are multimeric alpha-beta-beta-alpha sandwich proteins.
	gnl\|CDD\|143608	10	281	272	Gaps:19	99.61	258	35.41	15.56	3e-33	cd07584 nitrilase_6 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes the basic building block of which is a homodimer.
	gnl\|CDD\|143600	10	281	272	Gaps:24	99.21	254	32.14	15.08	8e-32	cd07576 R-amidase_like Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases). Pseudomonas sp. MCI3434 R-amidase hydrolyzes (R S)-piperazine-2-tert-butylcarboxamide to form (R)-piperazine-2-carboxylic acid. It does so with strict R-stereoselectively. Its preferred substrates are carboxamide compounds which have the amino or imino group connected to their beta- or gamma-carbon. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13) class 13 represents proteins that at the time were difficult to place in a distinct similarity group. It has been suggested that this subgroup represents a new class. Members of the nitrilase superfamily generally form homomeric complexes the basic building block of which is a homodimer. Native R-amidase however appears to be a monomer.
rpsblast_kog	gnl\|CDD\|36024	1	282	282	Gaps:16	96.64	298	39.24	16.32	2e-75	KOG0806 KOG0806 KOG0806 Carbon-nitrogen hydrolase [Amino acid transport and metabolism].
	gnl\|CDD\|36025	7	281	275	Gaps:12	91.86	295	32.47	19.56	4e-45	KOG0807 KOG0807 KOG0807 Carbon-nitrogen hydrolase [Amino acid transport and metabolism].
	gnl\|CDD\|35476	1617	2136	520	Gaps:93	83.88	521	17.39	18.76	3e-15	KOG0255 KOG0255 KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) [General function prediction only].
	gnl\|CDD\|36023	9	271	263	Gaps:61	83.09	337	26.79	16.43	6e-14	KOG0805 KOG0805 KOG0805 Carbon-nitrogen hydrolase [Amino acid transport and metabolism].
	gnl\|CDD\|36026	10	219	210	Gaps:14	52.71	387	25.00	17.16	1e-06	KOG0808 KOG0808 KOG0808 Carbon-nitrogen hydrolase [Amino acid transport and metabolism].

Other analysis

Functional Gbrowse

Ortholog