GRS - Genome Report System

Botrytis cinerea B0510 GRS

Functional annotation

BC1G_07144.1

Gene Identifier

Domain/Motif (Interproscan results)

Localization / Targeting

Blast based analysis

Analysis	Hit	start	end	length	Note	Hit coverage	Hit length	Hit pident	Hit pcons	eValue	Hit description
blastp_kegg	bfu:BC1G_07144	1	413	413	n/a	100.00	413	96.61	0.00	0.0	similar to MpkA
	ssl:SS1G_05445	1	413	413	n/a	100.00	413	96.37	0.24	0.0	similar to MAP kinase Mps1
	mgr:MGG_04943	1	412	412	Gaps:5	100.00	415	87.95	3.13	0.0	MG04943.4 similar to MAP kinase Mps1 K04464 mitogen-activated protein kinase 7 [EC:2.7.11.24]
	fgr:FG10313.1	1	412	412	Gaps:3	99.76	416	86.99	2.89	0.0	similar to AF492766_1 MAP kinase
	cim:CIMG_01981	1	412	412	Gaps:9	100.00	421	83.37	4.28	0.0	similar to MAP protein kinase MPKA
	act:ACLA_052670	1	410	410	Gaps:11	99.76	422	82.90	4.04	0.0	MAP kinase MpkA
	ang:An01g09520	1	410	410	Gaps:10	99.76	421	83.10	3.57	0.0	hypothetical protein K04464 mitogen-activated protein kinase 7 [EC:2.7.11.24]
	pcs:Pc22g03870	1	410	410	Gaps:9	99.29	422	83.29	3.34	0.0	Pc22g03870
	pan:PODANSg9198	1	406	406	Gaps:8	99.76	413	84.22	3.16	0.0	hypothetical protein
	nfi:NFIA_102670	1	410	410	Gaps:11	99.76	422	82.66	3.80	0.0	MAP kinase MpkA
blastp_uniprot_sprot	sp\|Q92398\|SPM1_SCHPO	8	359	352	Gaps:2	83.89	422	74.01	8.76	1e-150	Mitogen-activated protein kinase spm1 OS Schizosaccharomyces pombe GN spm1 PE 1 SV 1
	sp\|Q00772\|SLT2_YEAST	1	359	359	Gaps:4	75.00	484	67.77	12.95	1e-146	Mitogen-activated protein kinase SLT2/MPK1 OS Saccharomyces cerevisiae GN SLT2 PE 1 SV 2
	sp\|P43068\|MKC1_CANAL	6	359	354	Gaps:21	74.85	501	65.60	11.73	1e-145	Mitogen-activated protein kinase MKC1 OS Candida albicans GN MKC1 PE 3 SV 1
	sp\|O94737\|MAPK1_PNECA	9	355	347	Gaps:2	94.32	370	66.76	13.47	1e-142	Mitogen-activated protein kinase 1 OS Pneumocystis carinii GN MKP1 PE 1 SV 1
	sp\|P36005\|KKQ1_YEAST	1	359	359	Gaps:4	83.83	433	53.44	17.63	1e-113	Probable serine/threonine-protein kinase YKL161C OS Saccharomyces cerevisiae GN YKL161C PE 1 SV 1
	sp\|P42525\|ERK1_DICDI	12	336	325	Gaps:5	60.87	529	53.42	17.08	2e-98	Extracellular signal-regulated kinase 1 OS Dictyostelium discoideum GN erkA PE 2 SV 2
	sp\|Q84UI5\|MPK1_ORYSJ	6	335	330	Gaps:12	81.91	398	56.13	14.42	8e-97	Mitogen-activated protein kinase 1 OS Oryza sativa subsp. japonica GN MPK1 PE 1 SV 1
	sp\|Q40531\|NTF6_TOBAC	5	354	350	Gaps:16	93.80	371	53.74	15.80	5e-96	Mitogen-activated protein kinase homolog NTF6 OS Nicotiana tabacum GN NTF6 PE 2 SV 1
	sp\|Q40353\|MMK2_MEDSA	10	354	345	Gaps:9	92.18	371	52.34	16.96	6e-96	Mitogen-activated protein kinase homolog MMK2 OS Medicago sativa GN MMK2 PE 2 SV 1
	sp\|Q40532\|NTF4_TOBAC	6	335	330	Gaps:12	82.95	393	55.83	13.80	9e-96	Mitogen-activated protein kinase homolog NTF4 OS Nicotiana tabacum GN NTF4 PE 2 SV 1
blastp_pdb	2e14_A	12	359	348	Gaps:8	94.02	368	52.31	17.92	1e-92	mol:protein length:368 Mitogen-activated protein kinase 1
	1wzy_A	12	359	348	Gaps:8	94.02	368	52.31	17.92	1e-92	mol:protein length:368 Mitogen-activated protein kinase 1
	1tvo_A	12	359	348	Gaps:8	94.02	368	52.31	17.92	1e-92	mol:protein length:368 Mitogen-activated protein kinase 1
	4erk_A	12	359	348	Gaps:8	95.05	364	52.31	17.92	1e-92	mol:protein length:364 EXTRACELLULAR REGULATED KINASE 2
	3erk_A	12	359	348	Gaps:8	95.05	364	52.31	17.92	1e-92	mol:protein length:364 EXTRACELLULAR REGULATED KINASE 2
	3c9w_B	12	359	348	Gaps:8	96.92	357	52.31	17.92	1e-92	mol:protein length:357 Mitogen-activated protein kinase 1
	3c9w_A	12	359	348	Gaps:8	96.92	357	52.31	17.92	1e-92	mol:protein length:357 Mitogen-activated protein kinase 1
	2z7l_A	12	359	348	Gaps:8	94.54	366	52.31	17.92	1e-92	mol:protein length:366 Mitogen-activated protein kinase 1
	2fys_A	12	359	348	Gaps:8	95.05	364	52.31	17.92	1e-92	mol:protein length:364 Mitogen-activated protein kinase 1
	2fys_B	12	359	348	Gaps:8	95.05	364	52.31	17.92	1e-92	mol:protein length:364 Mitogen-activated protein kinase 1
rpsblast_cdd	gnl\|CDD\|173750	22	351	330	Gaps:2	100.00	332	78.31	9.64	0.0	cd07857 STKc_MPK1 Catalytic domain of the Serine/Threonine Kinase Fungal Mitogen-Activated Protein Kinase MPK1. Serine/Threonine Kinases (STKs) Fungal Mitogen-Activated Protein Kinase (MAPK) MPK1 subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae Pmk1 from Schizosaccharomyces pombe and similar proteins. MAPKs are important mediators of cellular responses to extracellular signals. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity (CWI) pathway and are therefore important in the maintainance of cell shape cell wall construction morphogenesis and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation osmotic shock UV irradiation and any agents that interfere with cell wall biogenesis such as chitin antagonists caffeine or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2 which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures hyper- or hypotonic stress glucose deprivation exposure to cell-wall damaging compounds and oxidative stress. It is regulated by the MAP2K Pek1 which is regulated by the MAP3K Mkh1.
	gnl\|CDD\|173737	22	350	329	Gaps:5	100.00	330	56.97	15.76	1e-151	cd07834 STKc_MAPK Catalytic domain of the Serine/Threonine Kinase Mitogen-Activated Protein Kinase. Serine/Threonine Kinases (STKs) Mitogen-Activated Protein Kinase (MAPK) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK) which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase a MAP4K. There are three main typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK) c-Jun N-terminal Kinase (JNK) and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4 MAPK6 NLK and ERK7.
	gnl\|CDD\|143354	17	353	337	Gaps:9	100.00	336	55.95	17.86	1e-135	cd07849 STKc_ERK1_2_like Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) Extracellular signal-regulated kinases 1 and 2 (ERK1/2) and Fus3 subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1 ERK2 baker's yeast Fus3 and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors differentiation stimuli and cytokines through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth cell proliferation and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined it is known that ERK2 can maintain most functions in the absence of ERK1 and that the deletion of ERK2 is embryonically lethal. The MAPK Fus3 regulates yeast mating processes including mating-specific gene expression G1 arrest mating projection and cell fusion.
	gnl\|CDD\|143363	17	354	338	Gaps:9	99.41	337	58.21	14.03	1e-132	cd07858 STKc_TEY_MAPK_plant Catalytic domain of the Serine/Threonine Kinases TEY Mitogen-Activated Protein Kinases from Plants. Serine/Threonine Kinases (STKs) Plant TEY Mitogen-Activated Protein Kinase (MAPK) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. MAPKs are important mediators of cellular responses to extracellular signals. In plants MAPKs are associated with physiological developmental hormonal and stress responses. Some plants show numerous gene duplications of MAPKs. Arabidopsis thaliana harbors at least 20 MAPKs named AtMPK1-20. There are two subtypes of plant MAPKs based on the conserved phosphorylation motif present in the activation loop TEY and TDY. This subfamily represents the TEY subtype and is further subdivided into three groups (A B and C). Group A is represented by AtMPK3 AtMPK6 Nicotiana tabacum BTF4 (NtNTF4) among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4 AtMPK13 and NtNTF6 among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1 AtMPK2 NtNTF3 Oryza sativa MAPK4 (OsMAPK4) among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3.
	gnl\|CDD\|173749	17	345	329	Gaps:1	98.20	334	55.18	16.46	1e-128	cd07855 STKc_ERK5 Catalytic domain of the Serine/Threonine Kinase Extracellular signal-Regulated Kinase 5. Serine/Threonine Kinases (STKs) Extracellular signal-Regulated Kinase 5 (ERK5) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. MAPKs are important mediators of cellular responses to extracellular signals. ERK5 also called Big MAPK1 (BMK1) or MAPK7 has a unique C-terminal extension making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5 which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2) Sap1a c-Myc and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer cardiac hypertrophy and atherosclerosis.
	gnl\|CDD\|143356	19	356	338	Gaps:13	96.50	343	49.85	16.92	1e-115	cd07851 STKc_p38 Catalytic domain of the Serine/Threonine Kinase p38 Mitogen-Activated Protein Kinase. Serine/Threonine Kinases (STKs) p38 subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. p38 kinases are mitogen-activated protein kinases (MAPKs) serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle cell development cell differentiation senescence tumorigenesis apoptosis pain development and pain progression and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6 which in turn are activated by upstream MAPK kinase kinases including TAK1 ASK1 and MLK3 in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription nuclear export mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis rheumatoid arthritis and chronic pulmonary disease. Vertebrates contain four isoforms of p38 named alpha beta gamma and delta which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed p38gamma is predominantly found in skeletal muscle and p38delta is found in the heart lung testis pancreas and small intestine.
	gnl\|CDD\|173747	19	327	309	Gaps:4	91.10	337	46.25	18.89	2e-99	cd07852 STKc_MAPK15 Catalytic domain of the Serine/Threonine Kinase Mitogen-Activated Protein Kinase 15. Serine/Threonine Kinases (STKs) Mitogen-Activated Protein Kinase 15 (MAPK15) subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. MAPKs are important mediators of cellular responses to extracellular signals. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors.
	gnl\|CDD\|143361	12	334	323	Gaps:14	94.82	328	49.52	16.72	8e-96	cd07856 STKc_Sty1_Hog1 Catalytic domain of the Serine/Threonine Kinases Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1. Serine/Threonine Kinases (STKs) Fungal Mitogen-Activated Protein Kinase (MAPK) Sty1/Hog1 subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe Hog1 from Saccharomyces cerevisiae and similar proteins. MAPKs are important mediators of cellular responses to extracellular signals. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress osmotic stress and UV radiation. Sty1 is regulated by the MAP2K Wis1 which is activated by the MAP3Ks Wis4 and Win1 which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response (CESR). Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors Sln1 and Sho1.
	gnl\|CDD\|143333	23	314	292	Gaps:11	100.00	283	46.29	14.84	3e-93	cd05118 STKc_CMGC Catalytic domain of CMGC family Serine/Threonine Kinases. Serine/Threonine Kinases (STKs) CMGC family catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs) Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs) c-Jun N-terminal kinases (JNKs) and p38 and similar proteins. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together they are involved in the control of cell-cycle progression transcription and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation proliferation migration and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer stroke diabetes and chronic inflammation.
	gnl\|CDD\|143384	19	354	336	Gaps:14	95.91	342	48.48	17.07	6e-93	cd07879 STKc_p38delta_MAPK13 Catalytic domain of the Serine/Threonine Kinase p38delta Mitogen-Activated Protein Kinase. Serine/Threonine Kinases (STKs) p38delta subfamily catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs protein tyrosine kinases RIO kinases aminoglycoside phosphotransferase choline kinase and phosphoinositide 3-kinase. p38 kinases are mitogen-activated protein kinases (MAPKs) serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6 which in turn are activated by upstream MAPK kinase kinases including TAK1 ASK1 and MLK3 in response to cellular stresses or inflammatory cytokines. Vertebrates contain four isoforms of p38 named alpha beta gamma and delta. p38delta also called MAPK13 is found in skeletal muscle heart lung testis pancreas and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes.
rpsblast_kog	gnl\|CDD\|35879	9	359	351	Gaps:5	96.94	359	56.32	14.94	1e-134	KOG0660 KOG0660 KOG0660 Mitogen-activated protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35883	27	314	288	Gaps:14	64.14	449	45.83	18.40	5e-69	KOG0664 KOG0664 KOG0664 Nemo-like MAPK-related serine/threonine protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35878	21	314	294	Gaps:15	88.99	318	43.82	15.90	9e-69	KOG0659 KOG0659 KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK kinase subunit CDK7 [Cell cycle control cell division chromosome partitioning Transcription Replication recombination and repair].
	gnl\|CDD\|35880	18	313	296	Gaps:11	53.35	538	39.02	19.16	4e-68	KOG0661 KOG0661 KOG0661 MAPK related serine/threonine protein kinase [Signal transduction mechanisms].
	gnl\|CDD\|35820	21	328	308	Gaps:9	53.75	560	36.54	17.61	3e-65	KOG0600 KOG0600 KOG0600 Cdc2-related protein kinase [Cell cycle control cell division chromosome partitioning].
	gnl\|CDD\|35884	17	357	341	Gaps:29	93.77	369	41.33	17.63	4e-65	KOG0665 KOG0665 KOG0665 Jun-N-terminal kinase (JNK) [Signal transduction mechanisms].
	gnl\|CDD\|35882	21	315	295	Gaps:13	69.21	419	35.52	20.00	7e-58	KOG0663 KOG0663 KOG0663 Protein kinase PITSLRE and related kinases [General function prediction only].
	gnl\|CDD\|35814	21	315	295	Gaps:15	91.64	323	37.84	19.59	8e-58	KOG0594 KOG0594 KOG0594 Protein kinase PCTAIRE and related kinases [General function prediction only].
	gnl\|CDD\|35877	22	350	329	Gaps:28	89.29	364	35.38	16.31	1e-53	KOG0658 KOG0658 KOG0658 Glycogen synthase kinase-3 [Carbohydrate transport and metabolism].
	gnl\|CDD\|35885	21	404	384	Gaps:47	92.01	438	32.26	14.39	2e-52	KOG0666 KOG0666 KOG0666 Cyclin C-dependent kinase CDK8 [Transcription].

Other analysis

Functional Gbrowse

Ortholog