GRS - Genome Report System

Botrytis cinerea B0510 GRS

Functional annotation

BC1G_06772.1

Gene Identifier

Domain/Motif (Interproscan results)

Localization / Targeting

Blast based analysis

Analysis	Hit	start	end	length	Note	Hit coverage	Hit length	Hit pident	Hit pcons	eValue	Hit description
blastp_kegg	bfu:BC1G_06772	1	1615	1615	n/a	100.00	1615	96.72	0.00	0.0	hypothetical protein K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
	ssl:SS1G_03224	1	1615	1615	Gaps:21	59.14	2697	85.20	5.45	0.0	hypothetical protein K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
	pan:PODANSg5154	1	1615	1615	Gaps:80	55.22	2847	53.12	15.78	0.0	hypothetical protein K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
	mgr:MGG_11316	1	1610	1610	Gaps:25	45.98	3510	50.06	17.16	0.0	MG08909.4 MG08910.4 hypothetical protein
	ncr:NCU00274	1	1608	1608	Gaps:43	54.45	2924	50.94	16.77	0.0	hypothetical protein
	fgr:FG05519.1	1	1615	1615	Gaps:64	56.13	2813	50.92	15.96	0.0	hypothetical protein K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
	cim:CIMG_09300	1	1615	1615	Gaps:25	77.36	2080	47.17	17.22	0.0	hypothetical protein K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
	ure:UREG_04998	1	1615	1615	Gaps:22	61.08	2639	46.65	17.43	0.0	hypothetical protein K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
	nfi:NFIA_074550	1	1615	1615	Gaps:24	56.89	2823	45.95	17.75	0.0	phosphatidylinositol 3- and 4-kinase putative K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
	afm:AFUA_5G12660	1	1615	1615	Gaps:43	57.73	2815	45.85	17.54	0.0	phosphotidylinositol kinase Tel1 K04728 ataxia telangectasia mutated family protein [EC:2.7.11.1]
blastp_uniprot_sprot	sp\|Q7RZT9\|ATM_NEUCR	1	1615	1615	Gaps:26	54.98	2939	51.61	16.46	0.0	Serine/threonine-protein kinase tel-1 OS Neurospora crassa GN tel-1 PE 3 SV 2
	sp\|Q4IB89\|ATM_GIBZE	1	1615	1615	Gaps:64	56.13	2813	50.92	15.96	0.0	Serine/threonine-protein kinase TEL1 OS Gibberella zeae GN TEL1 PE 3 SV 1
	sp\|Q4WVM7\|ATM_ASPFU	1	1615	1615	Gaps:24	57.44	2796	46.33	17.75	0.0	Serine/threonine-protein kinase tel1 OS Aspergillus fumigatus GN tel1 PE 3 SV 2
	sp\|Q2U639\|ATM_ASPOR	1	1615	1615	Gaps:49	55.86	2925	44.19	18.54	0.0	Serine/threonine-protein kinase tel1 OS Aspergillus oryzae GN tel1 PE 3 SV 1
	sp\|Q5BHE2\|ATM_EMENI	1	1615	1615	Gaps:32	57.68	2793	45.56	16.95	0.0	Serine/threonine-protein kinase tel1 OS Emericella nidulans GN tel1 PE 3 SV 1
	sp\|O74630\|ATM_SCHPO	438	1614	1177	Gaps:70	40.93	2812	33.54	19.90	1e-172	Serine/threonine-protein kinase tel1 OS Schizosaccharomyces pombe GN tel1 PE 1 SV 1
	sp\|Q13315\|ATM_HUMAN	439	1615	1177	Gaps:159	40.97	3056	30.51	18.05	1e-132	Serine-protein kinase ATM OS Homo sapiens GN ATM PE 1 SV 2
	sp\|Q5KFE0\|ATM_CRYNE	516	1614	1099	Gaps:101	35.93	2967	31.71	20.36	1e-130	Serine/threonine-protein kinase TEL1 OS Cryptococcus neoformans GN TEL1 PE 3 SV 1
	sp\|Q62388\|ATM_MOUSE	439	1615	1177	Gaps:185	40.97	3066	30.65	16.72	1e-129	Serine-protein kinase ATM OS Mus musculus GN Atm PE 1 SV 1
	sp\|Q6PQD5\|ATM_PIG	439	1615	1177	Gaps:157	40.96	3057	30.27	17.81	1e-127	Serine-protein kinase ATM OS Sus scrofa GN ATM PE 3 SV 2
blastp_pdb	3ls8_B	1280	1523	244	Gaps:55	32.41	614	32.16	27.14	2e-10	mol:protein length:614 Phosphatidylinositol 3-kinase catalytic subun
	3ls8_A	1280	1523	244	Gaps:55	32.41	614	32.16	27.14	2e-10	mol:protein length:614 Phosphatidylinositol 3-kinase catalytic subun
	3ihy_E	1280	1523	244	Gaps:55	33.17	600	32.16	27.14	2e-10	mol:protein length:600 Phosphatidylinositol 3-kinase catalytic subun
	3ihy_D	1280	1523	244	Gaps:55	33.17	600	32.16	27.14	2e-10	mol:protein length:600 Phosphatidylinositol 3-kinase catalytic subun
	3ihy_C	1280	1523	244	Gaps:55	33.17	600	32.16	27.14	2e-10	mol:protein length:600 Phosphatidylinositol 3-kinase catalytic subun
	3ihy_B	1280	1523	244	Gaps:55	33.17	600	32.16	27.14	2e-10	mol:protein length:600 Phosphatidylinositol 3-kinase catalytic subun
	3ihy_A	1280	1523	244	Gaps:55	33.17	600	32.16	27.14	2e-10	mol:protein length:600 Phosphatidylinositol 3-kinase catalytic subun
rpsblast_cdd	gnl\|CDD\|119431	1257	1533	277	Gaps:4	100.00	279	59.50	15.41	1e-132	cd05171 PIKKc_ATM Ataxia telangiectasia mutated (ATM) catalytic domain The ATM catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATM is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATM contains a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. ATM is critical in the response to DNA double strand breaks (DSBs) caused by radiation. It is activated at the site of a DSB and phosphorylates key substrates that trigger pathways that regulate DNA repair and cell cycle checkpoints at the G1/S S phase and G2/M transition. Patients with the human genetic disorder Ataxia telangiectasia (A-T) caused by truncating mutations in ATM show genome instability increased cancer risk immunodeficiency compromised mobility and neurodegeneration. A-T displays clinical heterogeneity which is correlated to the degree of retained ATM activity..
	gnl\|CDD\|34637	559	1614	1056	Gaps:88	48.36	2105	23.18	16.80	3e-72	COG5032 TEL1 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication recombination and repair / Intracellular trafficking and secretion].
	gnl\|CDD\|119418	1260	1532	273	Gaps:42	98.31	237	45.92	18.03	4e-69	cd00892 PIKKc_ATR ATR (Ataxia telangiectasia and Rad3-related) catalytic domain The ATR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATR is also referred to as Mei-41 (Drosophila) Esr1/Mec1p (Saccharomyces cerevisiae) Rad3 (Schizosaccharomyces pombe) and FRAP-related protein (human). ATR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATR contains a UME domain of unknown function a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. Together with its downstream effector kinase Chk1 ATR plays a central role in regulating the replication checkpoint. ATR stabilizes replication forks by promoting the association of DNA polymerases with the fork. Preventing fork collapse is essential in preserving genomic integrity. ATR plays a role in normal cell growth and in response to DNA damage..
	gnl\|CDD\|119424	1257	1526	270	Gaps:48	100.00	222	50.90	16.22	7e-69	cd05164 PIKKc Phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily catalytic domain The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. Members include ATM (Ataxia telangiectasia mutated) ATR (Ataxia telangiectasia and Rad3-related) TOR (Target of rapamycin) SMG-1 (Suppressor of morphogenetic effect on genitalia-1) and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP ATM and TRRAP C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints genome surveillance mRNA surveillance and translation control..
	gnl\|CDD\|128451	1289	1532	244	Gaps:50	97.03	202	44.39	21.94	4e-55	smart00146 PI3Kc Phosphoinositide 3-kinase catalytic domain. Phosphoinositide 3-kinase isoforms participate in a variety of processes including cell motility the Ras pathway vesicle trafficking and secretion and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
	gnl\|CDD\|119429	1257	1531	275	Gaps:25	99.29	280	35.25	19.78	3e-52	cd05169 PIKKc_TOR TOR (Target of rapamycin) catalytic domain The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. TOR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). TOR contains a rapamycin binding domain a catalytic domain and a FATC (FRAP ATM and TRRAP C-terminal) domain at the C-terminus. It is also called FRAP (FK506 binding protein 12-rapamycin associated protein). TOR is a central component of the eukaryotic growth regulatory network. It controls the expression of many genes transcribed by all three RNA polymerases. It associates with other proteins to form two distinct complexes TORC1 and TORC2. TORC1 is involved in diverse growth-related functions including protein synthesis nutrient use and transport autophagy and stress responses. TORC2 is involved in organizing cytoskeletal structures..
	gnl\|CDD\|144156	1289	1532	244	Gaps:32	97.85	233	37.28	17.98	5e-52	pfam00454 PI3_PI4_kinase Phosphatidylinositol 3- and 4-kinase. Some members of this family probably do not have lipid kinase activity and are protein kinases.
	gnl\|CDD\|119416	1260	1526	267	Gaps:51	98.63	219	33.80	19.44	1e-46	cd00142 PI3Kc_like Phosphoinositide 3-kinase (PI3K)-like family catalytic domain The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. Members of the family include PI3K phosphoinositide 4-kinase (PI4K) PI3K-related protein kinases (PIKKs) and TRansformation/tRanscription domain-Associated Protein (TRRAP). PI3Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives while PI4K catalyze the phosphorylation of the 4-hydroxyl of PtdIns. PIKKs are protein kinases that catalyze the phosphorylation of serine/threonine residues especially those that are followed by a glutamine. PI3Ks play an important role in a variety of fundamental cellular processes including cell motility the Ras pathway vesicle trafficking and secretion immune cell activation and apoptosis. PI4Ks produce PtdIns(4)P the major precursor to important signaling phosphoinositides. PIKKs have diverse functions including cell-cycle checkpoints genome surveillance mRNA surveillance and translation control..
	gnl\|CDD\|119432	1258	1532	275	Gaps:44	99.15	235	39.06	19.74	9e-45	cd05172 PIKKc_DNA-PK DNA-dependent protein kinase (DNA-PK) catalytic domain The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. DNA-PK is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). DNA-PK is comprised of a regulatory subunit containing the Ku70/80 subunit and a catalytic subunit which contains a NUC194 domain of unknown function a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. It is part of a multi-component system involved in non-homologous end joining (NHEJ) a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology. DNA-PK functions as a molecular sensor for DNA damage that enhances the signal via phosphorylation of downstream targets. It may also act as a protein scaffold that aids the localization of DNA repair proteins to the site of DNA damage. DNA-PK also plays a role in the maintenance of telomeric stability and the prevention of chromosomal end fusion..
	gnl\|CDD\|119430	1260	1532	273	Gaps:42	98.70	307	29.37	19.47	5e-43	cd05170 PIKKc_SMG1 Suppressor of morphogenetic effect on genitalia-1 (SMG-1) catalytic domain The SMG-1 catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. SMG-1 is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). In addition to its catalytic domain SMG-1 contains a FATC (FRAP ATM and TRRAP C-terminal) domain at the C-terminus. SMG-1 plays a critical role in the mRNA surveillance mechanism known as non-sense mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) generated by genome mutations and by errors during transcription and splicing. SMG-1 phosphorylates Upf1 another central component of NMD at the C-terminus upon recognition of PTCs. The phosphorylation/dephosphorylation cycle of Upf1 is essential for promoting NMD..
rpsblast_kog	gnl\|CDD\|36110	468	1614	1147	Gaps:65	41.13	2806	32.50	17.42	0.0	KOG0892 KOG0892 KOG0892 Protein kinase ATM/Tel1 involved in telomere length regulation and DNA repair [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning].
	gnl\|CDD\|36108	551	1614	1064	Gaps:171	41.69	2382	24.97	18.23	6e-80	KOG0890 KOG0890 KOG0890 Protein kinase of the PI-3 kinase family involved in mitotic growth DNA repair and meiotic recombination [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning].
	gnl\|CDD\|36109	1256	1611	356	Gaps:30	16.23	2341	27.63	20.00	3e-42	KOG0891 KOG0891 KOG0891 DNA-dependent protein kinase [Replication recombination and repair].
	gnl\|CDD\|36124	1268	1523	256	Gaps:59	25.03	843	29.38	21.80	3e-16	KOG0906 KOG0906 KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal transduction [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport].
	gnl\|CDD\|36121	1289	1523	235	Gaps:57	22.90	847	30.41	23.71	2e-15	KOG0903 KOG0903 KOG0903 Phosphatidylinositol 4-kinase involved in intracellular trafficking and secretion [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport].
	gnl\|CDD\|36107	1298	1614	317	Gaps:42	8.82	3550	23.00	21.41	2e-12	KOG0889 KOG0889 KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1 component PI-3 kinase superfamily [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning].
	gnl\|CDD\|36120	1189	1523	335	Gaps:78	15.81	1803	27.72	20.35	4e-12	KOG0902 KOG0902 KOG0902 Phosphatidylinositol 4-kinase [Signal transduction mechanisms].
	gnl\|CDD\|36122	1201	1524	324	Gaps:86	26.39	1076	29.58	15.49	2e-11	KOG0904 KOG0904 KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110) [Signal transduction mechanisms].

Other analysis

Functional Gbrowse

Ortholog