| Analysis | rpsblast_cdd | Start | 311 |
| End | 415 | Strand | + |
| Length | 105 | Note | Gaps:5 |
| Hit Coverage | 98.08 | Hit Length | 104 |
| Hit Pident | 37.25 | E Val | 6e-29 |
| Hit Description | cd08001 WGR_PARP1_like WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins. The WGR domain is found in a variety of eukaryotic poly(ADP-ribose) polymerases (PARPs). It has been called WGR after the most conserved central motif of the domain. The domain typically occurs together with a catalytic PARP domain and is between 70 and 80 residues in length. It has been proposed to function as a nucleic acid binding domain. PARPs catalyze the NAD(+)-dependent synthesis of ADP-ribose polymers and their addition to various nuclear proteins. Higher eukaryotes contain several PARPs and and there may be up to 17 human PARP-like proteins with three of them (PARP-1 PARP-2 and PARP-3) containing a WGR domain. The synthesis of poly-ADP-ribose requires multiple enzymatic activities for initiation trans-ADP-ribosylation elongation branching and release of the polymer from the enzyme. This subfamily is composed of vertebrate PARP-1 and similar proteins including Arabidopsis thaliana PARP-1 and PARP-3. PARP-1 is the best-studied among the PARPs. It is a widely expressed nuclear chromatin-associated enzyme that possesses auto-mono-ADP-ribosylation (initiation) elongation and branching activities. PARP-1 is implicated in DNA damage and cell death pathways and is important in maintaining genomic stability and regulating cell proliferation differentiation neuronal function inflammation and aging. | Hit Pcons | 18.63 |
| Name | Qrob_P0747200.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0747200.2 | Quercus robur | 0.0 | egn | (M=2) PTHR15447//PTHR15447:SF12 - POLY [ADP-RIBOSE] POLYMERASE // SUBFAMILY NOT NAMED | EC:2.4.2.30 | validated |
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