| Analysis | rpsblast_cdd | Start | 27 |
| End | 84 | Strand | + |
| Length | 58 | Note | Gaps:5 |
| Hit Coverage | 19.50 | Hit Length | 323 |
| Hit Pident | 28.57 | E Val | 4e-08 |
| Hit Description | cd00145 POLBc DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic (polymerase) and degradative modes (exonucleases) and play roles in the processes of DNA replication repair and recombination. DNA-dependent DNA polymerases can be classified in six main groups based upon their phylogenetic relationships with E. coli polymerase I (class A) E. coli polymerase II (class B) E. coli polymerase III (class C) euryarchaeota polymerase II (class D) human polymerase beta (class x) E. coli UmuC/DinB and eukaryotic RAP 30/Xeroderma pigmentosum variant (class Y). Family B DNA polymerases include E. coli DNA polymerase II some eubacterial phage DNA polymerases nuclear replicative DNA polymerases (alpha delta epsilon and zeta) and eukaryotic viral and plasmid-borne enzymes. DNA polymerase is made up of distinct domains and sub-domains. The polymerase domain of DNA polymerase type B (Pol domain) is responsible for the template-directed polymerization of dNTPs onto the growing primer strand of duplex DNA that is usually magnesium dependent. In general the architecture of the Pol domain has been likened to a right hand with fingers thumb and palm sub-domains with a deep groove to accommodate the nucleic acid substrate. There are a few conserved motifs in the Pol domain of family B DNA polymerases. The conserved aspartic acid residues in the DTDS motifs of the palm sub-domain is crucial for binding to divalent metal ion and is suggested to be important for polymerase catalysis.. | Hit Pcons | 15.87 |
| Name | Qrob_P0678490.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0678490.2 | Quercus robur | 95.0 | egn | (M=2) PTHR10670 - DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A | EC:2.7.7.7 | validated |
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