| Analysis | rpsblast_cdd | Start | 1 |
| End | 90 | Strand | + |
| Length | 90 | Note | Gaps:1 |
| Hit Coverage | 36.55 | Hit Length | 249 |
| Hit Pident | 35.16 | E Val | 8e-14 |
| Hit Description | cd09868 PIN_XPG PIN domain of Xeroderma pigmentosum complementation group G (XPG) nuclease a structure-specific divalent-metal-ion dependent 5' nuclease and homologs. The Xeroderma pigmentosum complementation group G (XPG) nuclease plays a central role in nucleotide excision repair (NER) in cleaving DNA bubble structures or loops. XPG is a member of the structure-specific 5' nuclease family that catalyzes hydrolysis of DNA duplex-containing nucleic acid structures during DNA replication repair and recombination. These nucleases contain a PIN (PilT N terminus) domain with a helical arch/clamp region (I domain). In XPG PIN domains this arch region can be quite variable and extensive (400 - 800 residues) in length and is required for NER activity and for efficient processing of bubble substrates. Inserted within the PIN domain of these 5' nucleases is a H3TH (helix-3-turn-helix) domain an atypical helix-hairpin-helix-2-like region. Both the H3TH domain (not included here) and the helical arch/clamp region are involved in DNA binding. Nucleases within this group also have a carboxylate-rich active site that is involved in binding essential divalent metal ion cofactors (Mg2+/Mn2+). | Hit Pcons | 15.38 |
| Name | Qrob_P0612720.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0612720.2 | Quercus robur | 100.0 | egn | (M=3) K15338 - flap endonuclease GEN [EC:3.1.-.-] | validated |
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