Blast Analysis : gnl|CDD|143596

Analysis  rpsblast_cdd Start  1
End  85 Strand  +
Length  85 Note  none
Hit Coverage  32.08 Hit Length  265
Hit Pident  51.76 E Val  4e-36
Hit Description  cd07572 nit Nit1 Nit 2 and related proteins and the Nit1-like domain of NitFhit (class 10 nitrilases). This subgroup includes mammalian Nit1 and Nit2 the Nit1-like domain of the invertebrate NitFhit and various uncharacterized bacterial and archaeal Nit-like proteins. Nit1 and Nit2 are candidate tumor suppressor proteins. In NitFhit the Nit1-like domain is encoded as a fusion protein with the non-homologous tumor suppressor fragile histidine triad (Fhit). Mammalian Nit1 and Fhit may affect distinct signal pathways and both may participate in DNA damage-induced apoptosis. Nit1 is a negative regulator in T cells. Overexpression of Nit2 in HeLa cells leads to a suppression of cell growth through cell cycle arrest in G2. These Nit proteins and the Nit1-like domain of NitFhit belong to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13) this subgroup corresponds to class 10. Hit Pcons  14.12
Name  Qrob_P0472170.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0472170.2 Quercus robur 100.0 egn (M=1) KOG0806//KOG0807 - Carbon-nitrogen hydrolase [Amino acid transport and metabolism]. // Carbon-nitrogen hydrolase [Amino acid transport and metabolism].   EC:3.5.1.3 validated