| Analysis | rpsblast_cdd | Start | 264 |
| End | 500 | Strand | + |
| Length | 237 | Note | Gaps:7 |
| Hit Coverage | 100.00 | Hit Length | 232 |
| Hit Pident | 48.71 | E Val | 5e-86 |
| Hit Description | cd09254 AP_delta-COPI_MHD Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit. COPI complex-coated vesicles function in the early secretory pathway. They mediate the retrograde transport from the Golgi to the ER and intra-Golgi transport. COPI complex-coated vesicles consist of a small GTPase ADP-ribosylation factor 1 (ARF1) and a heteroheptameric coatomer composed of two subcomplexes F-COPI and B-COPI. ARF1 regulates COPI vesicle formation by recruiting the coatomer onto Golgi membranes to initiate its coat function. Coatomer complexes then bind cargo molecules and self-assemble to form spherical cages that yield COPI-coated vesicles. The heterotetrameric F-COPI subcomplex contains beta- gamma- delta- and zeta-COP subunits where beta- and gamma-COP subunits are related to the large AP subunits and delta- and zeta-COP subunits are related to the medium and small AP subunits respectively. Due to the sequence similarity to the AP complexes the F-COPI subcomplex might play a role in the cargo-binding. The heterotrimeric B-COPI contains alpha- beta- and epsilon-COP subunits which are not related to the adaptins. This subcomplex is thought to participate in the cage-forming and might serve a function similar to that of clathrin. This family corresponds to the mu homology domain of delta-subunit of COPI complex (delta-COP) which is distantly related to the C-terminal domain of mu chains among AP complexes. The delta-COP subunit appears tightly associated with the beta-COP subunit to confer its interaction with ARF1. In addition both delta- and beta-COP subunits contribute to a common binding site for arginine (R)-based signals which are sorting motifs conferring transient endoplasmic reticulum (ER) localization to unassembled subunits of multimeric membrane proteins. | Hit Pcons | 21.98 |
| Name | Qrob_P0286350.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0286350.2 | Quercus robur | 100.0 | egn | (M=2) PTHR10121 - COATOMER SUBUNIT DELTA | validated |
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