| Analysis | rpsblast_cdd | Start | 119 |
| End | 251 | Strand | + |
| Length | 133 | Note | Gaps:6 |
| Hit Coverage | 83.73 | Hit Length | 166 |
| Hit Pident | 29.50 | E Val | 2e-20 |
| Hit Description | cd09194 PLDc_yTdp1_1 Catalytic domain repeat 1 of yeast tyrosyl-DNA phosphodiesterase. Catalytic domain repeat 1 of yeast tyrosyl-DNA phosphodiesterase (yTdp1 EC 3.1.4.-). yTdp1 is involved in the repair of topoisomerase I DNA lesions by hydrolyzing the topoisomerase from the 3'-end of the DNA during double-strand break repair. Unlike human Tdp1 whose substrate-binding pocket can accommodate a fairly large topoisomerase I peptide fragment yTdp1 has a preference for substrates containing one to four amino acid residues. The monomeric yTdp1 contains two copies of a variant HKD motif (H-x-K-x(4)-D where x represents any amino acid residue) which consists of the highly conserved histidine and lysine residues but lacks the aspartate residue that is well conserved in other phospholipase D (PLD EC 3.1.4.4) enzymes. Like other PLD enzymes yTdp1 may utilize a common two-step general acid/base catalytic mechanism involving a DNA-enzyme intermediate to cleave phosphodiester bonds. A single active site involved in phosphatidyl group transfer would be formed by the two variant HKD motifs from the N- and C-terminal domains in a pseudodimeric way. | Hit Pcons | 16.55 |
| Name | Qrob_P0240460.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0240460.2 | Quercus robur | 0.0 | egn | (M=2) K10862 - tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] | EC:3.1.4.1 | validated |
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