Blast Analysis : gnl|CDD|175982

Analysis  rpsblast_cdd Start  20
End  183 Strand  +
Length  164 Note  Gaps:10
Hit Coverage  97.47 Hit Length  158
Hit Pident  49.35 E Val  3e-56
Hit Description  cd04015 C2_plant_PLD C2 domain present in plant phospholipase D (PLD). PLD hydrolyzes terminal phosphodiester bonds in diester glycerophospholipids resulting in the degradation of phospholipids. In vitro PLD transfers phosphatidic acid to primary alcohols. In plants PLD plays a role in germination seedling growth phosphatidylinositol metabolism and changes in phospholipid composition. There is a single Ca(2+)/phospholipid-binding C2 domain in PLD. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids inositol polyphosphates and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain such as protein kinase C or membrane trafficking proteins which contain at least two C2 domains such as synaptotagmin 1. However there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues primarily aspartates that serve as ligands for calcium ions. Hit Pcons  15.58
Name  Qrob_P0238260.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0238260.2 Quercus robur 100.0 egn (M=1) KOG1028//KOG1030//KOG1329//KOG2059 - Ca2+-dependent phospholipid-binding protein Synaptotagmin required for synaptic vesicle and secretory granule exocytosis [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport]. // Predicted Ca2+-dependent phospholipid-binding protein [General function prediction only]. // Phospholipase D1 [Lipid transport and metabolism]. // Ras GTPase-activating protein [Signal transduction mechanisms].   EC:3.1.4.4 validated