| Analysis | rpsblast_cdd | Start | 14 |
| End | 71 | Strand | + |
| Length | 58 | Note | Gaps:14 |
| Hit Coverage | 26.57 | Hit Length | 271 |
| Hit Pident | 30.56 | E Val | 1e-07 |
| Hit Description | cd09253 AP-4_Mu4_Cterm C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4. AP complexes participate in the formation of intracellular coated transport vesicles and select cargo molecules for incorporation into the coated vesicles in the late secretory and endocytic pathways. There are four AP complexes AP-1 AP-2 AP-3 and AP-4 described in various eukaryotic organisms. Each AP complex consists of four subunits: two large chains (one each of gamma/alpha/delta/epsilon and beta1-4 respectively) a medium mu chain (mu1-4) and a small sigma chain (sigma1-4). Each of the four subunits from the different AP complexes exhibits similarity with each other. This family corresponds to the C-terminal domain of heterotetrameric adaptor protein complex 4 (AP-4) medium mu4 subunit. AP-4 plays a role in signal-mediated trafficking of integral membrane proteins in mammalian cells. Unlike other AP complexes AP-4 is found only in mammals and plants. It is believed to be part of a nonclathrin coat since it might function independently of clathrin a scaffolding protein participating in the formation of coated vesicles. Recruitment of AP-4 to the trans-Golgi network (TGN) membrane is regulated by a small GTPase ADP-ribosylation factor 1 (ARF1) or a related protein. Membrane-anchored cargo molecules interact with adaptors through short sorting signals in their cytosolic segments. One of the most important sorting signals binding to mu subunits of AP complexes are tyrosine-based endocytotic signals which are of the form Y-X-X-Phi where Y is tyrosine X is any amino acid and Phi is a bulky hydrophobic residue that can be Leu Ile Met Phe or Val. However AP-4 does not bind most canonical tyrosine-based signals except for two naturally occurring ones from the lysosomal membrane proteins CD63 and LAMP-2a. It binds YX [FYL][FL]E motif where X can be any residue from the cytosolic tails of amyloid precursor protein (APP) family members in a distinct way. | Hit Pcons | 15.28 |
| Name | Qrob_P0068320.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0068320.2 | Quercus robur | 0.0 | egn | (M=1) PTHR11998:SF4 - CLATHRIN COAT ADAPTOR AP3 MEDIUM CHAIN | validated |
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