Blast Analysis : gnl|CDD|48510

Analysis	rpsblast_cdd	Start	93
End	178	Strand	+
Length	86	Note	Gaps:6
Hit Coverage	89.11	Hit Length	101
Hit Pident	31.11	E Val	2e-13
Hit Description	cd02961 PDI_a_family Protein Disulfide Isomerase (PDIa) family redox active TRX domains composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI and PDI-related proteins like ERp72 ERp57 (or ERp60) ERp44 P5 PDIR ERp46 and the transmembrane PDIs. PDI ERp57 ERp72 P5 PDIR and ERp46 are all oxidases catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER. They also exhibit reductase activity in acting as isomerases to correct any non-native disulfide bonds as well as chaperone activity to prevent protein aggregation and facilitate the folding of newly synthesized proteins. These proteins usually contain multiple copies of a redox active TRX (a) domain containing a CXXC motif and may also contain one or more redox inactive TRX-like (b) domains. Only one a domain is required for the oxidase function but multiple copies are necessary for the isomerase function. The different types of PDIs may show different substrate specificities and tissue-specific expression or may be induced by stress. PDIs are in their reduced form at steady state and are oxidized to the active form by Ero1 which is localized in the ER through ERp44. Some members of this family also contain a DnaJ domain in addition to the redox active a domains examples are ERdj5 and Pfj2. Also included in the family is the redox inactive N-terminal TRX-like domain of ERp29..	Hit Pcons	15.56
Name	Qrob_P0020390.2

1 Protein

Protein Identifier	Organism . Name	Score	Score Type	Protein Description	Alias (in v1)	Code Enzyme	Gene Prediction Quality
Qrob_P0020390.2	Quercus robur	28.1	egn	(M=1) PTHR18929:SF84 - 5'-ADENYLYLSULFATE REDUCTASE-LIKE 5-RELATED (PTHR18929:SF84)			validated

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