Protein : Qrob_P0707870.2 Q. robur
Protein Identifier  ? Qrob_P0707870.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K16609 - tubulin--tyrosine ligase-like protein 12 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 879  
Kegg Orthology  K16609
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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0006464 cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cic:CICLE_v10007418mg 7 878 + 872 Gaps:6 99.66 871 77.53 0.0 hypothetical protein
blastp_kegg lcl|vvi:100242318 7 878 + 872 Gaps:11 99.88 866 77.57 0.0 tubulin--tyrosine ligase-like protein 12-like
blastp_kegg lcl|tcc:TCM_037527 10 878 + 869 Gaps:14 98.85 869 77.30 0.0 Tubulin-tyrosine ligases tubulin-tyrosine ligases isoform 1
blastp_kegg lcl|cit:102615710 7 878 + 872 Gaps:6 99.66 871 76.38 0.0 tubulin--tyrosine ligase-like protein 12-like
blastp_kegg lcl|pper:PRUPE_ppa001302mg 10 878 + 869 Gaps:16 99.77 859 77.25 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0006s14420g 10 878 + 869 Gaps:7 99.77 868 77.14 0.0 tubulin-tyrosine ligase family protein
blastp_kegg lcl|cmo:103492368 8 878 + 871 Gaps:7 99.66 871 76.15 0.0 tubulin--tyrosine ligase-like protein 12
blastp_kegg lcl|csv:101208562 8 878 + 871 Gaps:11 99.66 875 75.80 0.0 tubulin--tyrosine ligase-like protein 12-like
blastp_kegg lcl|csv:101230272 8 878 + 871 Gaps:11 99.66 875 75.69 0.0 tubulin--tyrosine ligase-like protein 12-like
blastp_kegg lcl|pmum:103340588 10 878 + 869 Gaps:16 99.77 859 76.66 0.0 tubulin--tyrosine ligase-like protein 12
blastp_uniprot_sprot sp|Q3UDE2|TTL12_MOUSE 16 872 + 857 Gaps:86 93.58 639 39.13 5e-94 Tubulin--tyrosine ligase-like protein 12 OS Mus musculus GN Ttll12 PE 2 SV 1
blastp_uniprot_sprot sp|Q14166|TTL12_HUMAN 15 871 + 857 Gaps:89 94.10 644 38.28 3e-91 Tubulin--tyrosine ligase-like protein 12 OS Homo sapiens GN TTLL12 PE 1 SV 2
blastp_uniprot_sprot sp|Q09512|TTL12_CAEEL 14 878 + 865 Gaps:77 94.11 662 34.51 2e-74 Tubulin--tyrosine ligase-like protein 12 OS Caenorhabditis elegans GN ttll-12 PE 4 SV 1
blastp_uniprot_sprot sp|A8XXC0|TTL12_CAEBR 14 878 + 865 Gaps:76 91.67 672 33.44 5e-73 Tubulin--tyrosine ligase-like protein 12 OS Caenorhabditis briggsae GN ttll-12 PE 4 SV 2
blastp_uniprot_sprot sp|Q23K29|TTL3D_TETTS 651 847 + 197 Gaps:24 20.20 1015 32.20 2e-15 Tubulin glycylase 3D OS Tetrahymena thermophila (strain SB210) GN TTLL3D PE 3 SV 1
blastp_uniprot_sprot sp|Q23AS2|TTL3E_TETTS 629 849 + 221 Gaps:30 17.14 1394 27.62 6e-14 Tubulin glycylase 3E OS Tetrahymena thermophila (strain SB210) GN TTLL3E PE 3 SV 1
blastp_uniprot_sprot sp|A4Q9F0|TTLL7_MOUSE 572 861 + 290 Gaps:42 34.21 912 27.24 4e-13 Tubulin polyglutamylase TTLL7 OS Mus musculus GN Ttll7 PE 1 SV 1
blastp_uniprot_sprot sp|Q6ZT98|TTLL7_HUMAN 572 851 + 280 Gaps:42 34.05 887 27.48 4e-12 Tubulin polyglutamylase TTLL7 OS Homo sapiens GN TTLL7 PE 2 SV 2
blastp_uniprot_sprot sp|P0CAZ1|TTL3F_TETTS 657 840 + 184 Gaps:27 21.89 909 27.64 4e-12 Tubulin glycylase 3F OS Tetrahymena thermophila (strain SB210) GN TTLL3F PE 3 SV 1
blastp_uniprot_sprot sp|Q23FE2|TTL3C_TETTS 654 836 + 183 Gaps:20 18.66 1088 25.12 4e-11 Tubulin glycylase 3C OS Tetrahymena thermophila (strain SB210) GN TTLL3C PE 3 SV 1
rpsblast_cdd gnl|CDD|202548 599 847 + 249 Gaps:20 89.69 291 27.97 3e-47 pfam03133 TTL Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyzes the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells the tyrosinated form of tubulin predominates. However in breast cancer cells the detyrosinated form frequently predominates with a correlation to tumour aggressiveness. On the other hand 3-nitrotyrosine has been shown to be incorporated by TTL into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function including altered cell morphology epithelial barrier dysfunction and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.
rpsblast_kog gnl|CDD|37366 14 878 + 865 Gaps:51 99.05 631 41.76 0.0 KOG2155 KOG2155 KOG2155 Tubulin-tyrosine ligase-related protein [Posttranslational modification protein turnover chaperones].
rpsblast_kog gnl|CDD|37368 552 846 + 295 Gaps:47 66.40 497 20.91 3e-17 KOG2157 KOG2157 KOG2157 Predicted tubulin-tyrosine ligase [Posttranslational modification protein turnover chaperones].
rpsblast_kog gnl|CDD|37367 558 845 + 288 Gaps:49 45.47 662 27.24 1e-15 KOG2156 KOG2156 KOG2156 Tubulin-tyrosine ligase-related protein [Posttranslational modification protein turnover chaperones].
rpsblast_kog gnl|CDD|37369 690 836 + 147 Gaps:29 30.09 565 24.12 3e-08 KOG2158 KOG2158 KOG2158 Tubulin-tyrosine ligase-related protein [Posttranslational modification protein turnover chaperones].

9 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 279 346 68 G3DSA:3.80.10.10 none none none
SUPERFAMILY 166 383 218 SSF52047 none none none
PANTHER 13 132 120 PTHR12241:SF13 none none IPR027749
PANTHER 408 871 464 PTHR12241:SF13 none none IPR027749
Gene3D 165 247 83 G3DSA:3.80.10.10 none none none
PANTHER 13 132 120 PTHR12241 none none none
PANTHER 408 871 464 PTHR12241 none none none
ProSiteProfiles 544 872 329 PS51221 none TTL domain profile. IPR004344
Pfam 598 847 250 PF03133 none Tubulin-tyrosine ligase family IPR004344

0 Localization

10 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nPriLBD*_3P Qrob_Chr11 11 v_12066_307 s_1B15GJ_447 3,37 0,57 16,17 lod 3,4299 6,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Bourran2_2014_nP_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 7,9 0,09 30,09 lod 2,3636 5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9
Bourran1_2003_QTL6_peak_Bud_burst_A4 Qrob_Chr11 11 v_12066_307 s_1A9FKZ_348 3,59 0 20,89 lod 3,4 9,4
PM_1999_QTL17_peak_Bud_burst_3P Qrob_Chr11 11 s_1A9FKZ_348 v_11486_883 4,8 0 24,8 lod 3,5 6,2
Bourran_2000_2002_QTL5_Delta.F Qrob_Chr11 11 s_1BD29X_620 s_2F1WOG_696 2.94 1,08 16,39 lod 5.936 0.05
Bourran2_2014_vEpiBC*_3P Qrob_Chr11 11 s_1A5GRX_415 v_4456_500 9,37 0 19,27 lod 3,513 9,3
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL5_d13Cf Qrob_Chr11 11 s_1BD29X_620 s_1A5BYY_1671 2.26 1,08 11,24 lod 5.8451 0.037

0 Targeting