Protein : Qrob_P0636370.2 Q. robur
Protein Identifier  ? Qrob_P0636370.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) PTHR21297:SF1 - DNA-DIRECTED RNA POLYMERASE II Gene Prediction Quality  validated
Protein length 

Sequence

Length: 340  
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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0010508 positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

11 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa005050mg 1 339 + 339 Gaps:1 70.98 479 82.94 0.0 hypothetical protein
blastp_kegg lcl|pmum:103332959 1 339 + 339 Gaps:1 70.98 479 82.65 0.0 uncharacterized LOC103332959
blastp_kegg lcl|rcu:RCOM_0261650 1 339 + 339 Gaps:1 71.13 478 81.18 0.0 DNA-directed RNA polymerase II putative
blastp_kegg lcl|tcc:TCM_034990 1 339 + 339 Gaps:1 70.98 479 81.18 0.0 DNA-directed RNA polymerase II protein isoform 1
blastp_kegg lcl|cit:102626964 1 339 + 339 Gaps:1 71.13 478 81.76 0.0 uncharacterized LOC102626964
blastp_kegg lcl|pvu:PHAVU_008G169200g 1 339 + 339 Gaps:3 71.01 476 80.47 0.0 hypothetical protein
blastp_kegg lcl|gmx:100776426 1 339 + 339 Gaps:2 70.95 475 80.71 0.0 uncharacterized LOC100776426
blastp_kegg lcl|fve:101292418 1 339 + 339 Gaps:2 70.92 478 83.19 0.0 uncharacterized protein LOC101292418
blastp_kegg lcl|cam:101503483 1 339 + 339 Gaps:2 78.92 427 80.71 0.0 uncharacterized LOC101503483
blastp_kegg lcl|pop:POPTR_0002s09150g 1 339 + 339 Gaps:4 70.95 475 80.12 0.0 POPTRDRAFT_816318 hypothetical protein
rpsblast_cdd gnl|CDD|204411 1 229 + 229 Gaps:59 55.37 307 37.06 6e-35 pfam10186 Atg14 UV radiation resistance protein and autophagy-related subunit 14. The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY) a vacuolar-soluble hydrolase to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway. There are 17 auto-phagosomal component proteins which are categorized into six functional units one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localisation of this complex at the PAS is controlled by Atg14. Autophagy mediates the cellular response to nutrient deprivation protein aggregation and pathogen invasion in humans and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex.

3 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 1 233 233 PTHR21297 none none none
PANTHER 1 233 233 PTHR21297:SF1 none none none
Pfam 3 227 225 PF10186 none UV radiation resistance protein and autophagy-related subunit 14 IPR018791

0 Localization

1 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4

0 Targeting