Protein : Qrob_P0584940.2 Q. robur
Protein Identifier  ? Qrob_P0584940.2 Organism . Name  Quercus robur
Score  97.1 Score Type  egn
Protein Description  (M=1) K03351 - anaphase-promoting complex subunit 4 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 771  
Kegg Orthology  K03351
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0005680 anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
GO:0030071 regulation of mitotic metaphase/anaphase transition Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle.
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.

22 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_029983 1 746 + 746 Gaps:4 96.12 774 82.12 0.0 Transducin/WD40 repeat-like superfamily protein isoform 1
blastp_kegg lcl|vvi:100255109 1 746 + 746 Gaps:11 96.09 767 82.50 0.0 anaphase-promoting complex subunit 4-like
blastp_kegg lcl|pop:POPTR_0004s03490g 1 748 + 748 Gaps:11 98.67 753 81.43 0.0 POPTRDRAFT_817758 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10014364mg 1 746 + 746 Gaps:14 96.07 764 80.25 0.0 hypothetical protein
blastp_kegg lcl|pmum:103324640 1 746 + 746 Gaps:4 96.13 776 82.57 0.0 anaphase-promoting complex subunit 4
blastp_kegg lcl|cit:102627214 1 746 + 746 Gaps:13 96.07 763 79.81 0.0 anaphase-promoting complex subunit 4-like
blastp_kegg lcl|cam:101507734 1 746 + 746 Gaps:6 96.12 774 76.88 0.0 anaphase-promoting complex subunit 4-like
blastp_kegg lcl|pper:PRUPE_ppa001703mg 1 746 + 746 Gaps:4 96.13 776 81.37 0.0 hypothetical protein
blastp_kegg lcl|gmx:100527617 1 746 + 746 Gaps:3 96.14 777 75.10 0.0 uncharacterized LOC100527617
blastp_kegg lcl|pvu:PHAVU_002G222500g 1 746 + 746 Gaps:3 96.14 777 74.70 0.0 hypothetical protein
blastp_uniprot_sprot sp|O65418|APC4_ARATH 1 746 + 746 Gaps:5 95.62 777 71.60 0.0 Anaphase-promoting complex subunit 4 OS Arabidopsis thaliana GN APC4 PE 2 SV 2
blastp_uniprot_sprot sp|Q5RAQ5|APC4_PONAB 12 684 + 673 Gaps:122 79.68 817 26.73 9e-42 Anaphase-promoting complex subunit 4 OS Pongo abelii GN ANAPC4 PE 2 SV 1
blastp_uniprot_sprot sp|Q9UJX5|APC4_HUMAN 12 684 + 673 Gaps:122 80.57 808 26.27 6e-41 Anaphase-promoting complex subunit 4 OS Homo sapiens GN ANAPC4 PE 1 SV 2
blastp_uniprot_sprot sp|Q91W96|APC4_MOUSE 12 684 + 673 Gaps:116 80.67 807 25.81 4e-38 Anaphase-promoting complex subunit 4 OS Mus musculus GN Anapc4 PE 1 SV 1
blastp_uniprot_sprot sp|Q54NI1|APC4_DICDI 12 485 + 474 Gaps:120 62.84 837 22.81 9e-25 Anaphase-promoting complex subunit 4 OS Dictyostelium discoideum GN anapc4 PE 3 SV 1
blastp_uniprot_sprot sp|O42839|APC4_SCHPO 20 470 + 451 Gaps:52 58.55 719 20.90 3e-09 Anaphase-promoting complex subunit 4 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN cut20 PE 1 SV 2
rpsblast_cdd gnl|CDD|205132 264 472 + 209 Gaps:1 100.00 208 33.17 1e-46 pfam12896 Apc4 Anaphase-promoting complex cyclosome subunit 4. Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organism.
rpsblast_cdd gnl|CDD|205130 11 57 + 47 none 100.00 47 48.94 7e-13 pfam12894 Apc4_WD40 Anaphase-promoting complex subunit 4 WD40 domain. Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5 both of which lie towards the bottom-front of the APC .
rpsblast_cdd gnl|CDD|29257 22 189 + 168 Gaps:108 95.50 289 35.87 4e-08 cd00200 WD40 WD40 domain found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction pre-mRNA processing and cytoskeleton assembly typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long hence the name WD40 between GH and WD lies a conserved core serves as a stable propeller-like platform to which proteins can bind either stably or reversibly forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet instances with few detectable copies are hypothesized to form larger structures by dimerization each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands 7 copies of the repeat are present in this alignment..
rpsblast_kog gnl|CDD|39840 9 684 + 676 Gaps:143 98.20 665 26.95 1e-101 KOG4640 KOG4640 KOG4640 Anaphase-promoting complex (APC) subunit 4 [Cell cycle control cell division chromosome partitioning Posttranslational modification protein turnover chaperones].
rpsblast_kog gnl|CDD|35487 64 189 + 126 Gaps:17 23.90 456 25.69 5e-10 KOG0266 KOG0266 KOG0266 WD40 repeat-containing protein [General function prediction only].
rpsblast_kog gnl|CDD|35492 64 135 + 72 Gaps:1 14.79 480 32.39 5e-07 KOG0271 KOG0271 KOG0271 Notchless-like WD40 repeat-containing protein [Function unknown].

13 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 1 748 748 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 265 472 208 PF12896 "UniPathway:UPA00143" Anaphase-promoting complex, cyclosome, subunit 4 IPR024790
SUPERFAMILY 173 241 69 SSF50978 none none IPR017986
SUPERFAMILY 19 117 99 SSF50978 none none IPR017986
Phobius 749 769 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 12 57 46 PF12894 none Anaphase-promoting complex subunit 4 WD40 domain IPR024977
SMART 93 130 38 SM00320 none WD40 repeats IPR001680
SMART 51 89 39 SM00320 none WD40 repeats IPR001680
Gene3D 176 189 14 G3DSA:2.130.10.10 none none IPR015943
Gene3D 23 116 94 G3DSA:2.130.10.10 none none IPR015943
Phobius 770 770 1 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 63 89 27 PF00400 none WD domain, G-beta repeat IPR001680
PANTHER 1 745 745 PTHR13260 "UniPathway:UPA00143";signature_desc=ANAPHASE PROMOTING COMPLEX SUBUNIT 4 (APC4) (CYCLOSOME SUBUNIT 4) none IPR024789

0 Localization

7 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL5_peak_Bud_burst_A4 Qrob_Chr10 10 s_1C8OKQ_688 v_12844_707 25,6 13,9 39,9 lod 2,7 6,1
Bourran2_2002_QTL13_peak_Bud_burst_3P Qrob_Chr10 10 s_1B1AG7_637 s_1A3A1N_709 19,44 0 49,44 lod 3 5,6
Bourran2_2002_QTL15_peak_Bud_burst_A4 Qrob_Chr10 10 v_7579_71 s_1ATZMJ_189 23,94 0 43,64 lod 3,7 5,4
Bourran2_2014_vSeqBC_3P Qrob_Chr10 10 s_1A6CK6_610 v_7092_29 4,28 0 23,27 lod 2,8619 7
Bourran2_2014_vSeqBC_A4 Qrob_Chr10 10 s_1BAM4E_1326 s_1C0HD0_1012 36,88 7,71 46,03 lod 2,6164 7,3
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5
PM_1999_QTL16_peak_Bud_burst_3P Qrob_Chr10 10 s_1B6YNI_505 s_1A1ZO_1322 7,48 0 31,48 lod 4 7,1

0 Targeting