Protein : Qrob_P0583750.2 Q. robur
Protein Identifier  ? Qrob_P0583750.2 Organism . Name  Quercus robur
Score  99.0 Score Type  egn
Protein Description  (M=3) 3.2.1.167 - Baicalin-beta-D-glucuronidase. Code Enzyme  EC:3.2.1.31, EC:3.2.1.167
Gene Prediction Quality  validated Protein length 

Sequence

Length: 579  
Kegg Orthology  K07964
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0016798 hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond.
GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

21 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100259360 34 577 + 544 Gaps:17 98.36 548 69.20 0.0 heparanase-like protein 3-like
blastp_kegg lcl|tcc:TCM_036966 33 577 + 545 Gaps:14 98.91 549 67.77 0.0 Glucuronidase 3 isoform 1
blastp_kegg lcl|cit:102608348 33 577 + 545 Gaps:20 96.08 561 67.90 0.0 heparanase-like protein 3-like
blastp_kegg lcl|pmum:103319726 32 577 + 546 Gaps:20 98.69 535 70.08 0.0 heparanase-like protein 3
blastp_kegg lcl|cic:CICLE_v10010401mg 33 577 + 545 Gaps:16 98.91 551 66.61 0.0 hypothetical protein
blastp_kegg lcl|pper:PRUPE_ppa019445mg 56 577 + 522 Gaps:17 99.22 511 71.40 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0018s02050g 19 577 + 559 Gaps:16 97.87 563 67.33 0.0 POPTRDRAFT_261180 hypothetical protein
blastp_kegg lcl|rcu:RCOM_0923130 63 577 + 515 Gaps:14 96.96 527 70.45 0.0 heparanase putative
blastp_kegg lcl|vvi:100264535 51 578 + 528 Gaps:23 84.15 612 69.51 0.0 heparanase-like protein 3
blastp_kegg lcl|vvi:100255842 32 577 + 546 Gaps:24 98.75 559 63.95 0.0 heparanase-like protein 3-like
blastp_uniprot_sprot sp|Q9FZP1|HPSE3_ARATH 25 577 + 553 Gaps:32 99.81 536 55.70 0.0 Heparanase-like protein 3 OS Arabidopsis thaliana GN At5g34940 PE 2 SV 2
blastp_uniprot_sprot sp|Q8L608|HPSE2_ARATH 68 578 + 511 Gaps:16 94.81 539 47.95 6e-171 Heparanase-like protein 2 OS Arabidopsis thaliana GN At5g61250 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FF10|HPSE1_ARATH 65 578 + 514 Gaps:17 94.84 543 47.57 1e-165 Heparanase-like protein 1 OS Arabidopsis thaliana GN At5g07830 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LRC8|BAGLU_SCUBA 76 577 + 502 Gaps:50 91.84 527 50.00 7e-162 Baicalin-beta-D-glucuronidase OS Scutellaria baicalensis GN SGUS PE 1 SV 1
blastp_uniprot_sprot sp|Q90YK5|HPSE_CHICK 182 577 + 396 Gaps:53 71.32 523 29.76 7e-26 Heparanase OS Gallus gallus GN HPSE PE 1 SV 1
blastp_uniprot_sprot sp|Q9Y251|HPSE_HUMAN 137 467 + 331 Gaps:36 58.75 543 28.84 1e-25 Heparanase OS Homo sapiens GN HPSE PE 1 SV 2
blastp_uniprot_sprot sp|Q71RP1|HPSE_RAT 133 577 + 445 Gaps:99 85.07 536 29.17 2e-25 Heparanase OS Rattus norvegicus GN Hpse PE 2 SV 1
blastp_uniprot_sprot sp|Q9MYY0|HPSE_BOVIN 137 577 + 441 Gaps:65 74.13 545 28.22 2e-25 Heparanase OS Bos taurus GN HPSE PE 2 SV 2
blastp_uniprot_sprot sp|Q6YGZ1|HPSE_MOUSE 182 467 + 286 Gaps:35 53.64 535 33.45 3e-25 Heparanase OS Mus musculus GN Hpse PE 1 SV 3
blastp_uniprot_sprot sp|Q8WWQ2|HPSE2_HUMAN 182 577 + 396 Gaps:76 64.53 592 28.80 7e-18 Inactive heparanase-2 OS Homo sapiens GN HPSE2 PE 1 SV 3
rpsblast_cdd gnl|CDD|190706 65 388 + 324 Gaps:10 99.38 320 61.01 1e-143 pfam03662 Glyco_hydro_79n Glycosyl hydrolase family 79 N-terminal domain. Family of endo-beta-N-glucuronidase or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly insolubility and barrier properties of basement membranes and extracellular matrices. Hence cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.

10 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 216 422 207 G3DSA:3.20.20.80 none none IPR013781
Phobius 24 45 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 79 432 354 SSF51445 none none IPR017853
Phobius 46 578 533 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 496 578 83 PTHR14363 none none IPR005199
PANTHER 68 472 405 PTHR14363 none none IPR005199
Pfam 65 388 324 PF03662 none Glycosyl hydrolase family 79, N-terminal domain IPR005199
PANTHER 496 578 83 PTHR14363:SF11 none none none
PANTHER 68 472 405 PTHR14363:SF11 none none none
Phobius 1 23 23 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none

1 Localization

Analysis Start End Length
TMHMM 24 46 22

19 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran2_2004_QTL9_peak_Bud_burst_3P Qrob_Chr02 2 s_1C34E9_788 v_12238_322 50 25 75 lod 4,4 10,1
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL2_d13Cf Qrob_Chr02 2 s_1AQA4Z_1644 s_1AK5QX_947 53.67 14,01 79,68 lod 5.6594 0.03
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran2_2002_QTL7_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 29 52 lod 8,1 16
Bourran2_2002_QTL9_peak_Bud_burst_A4 Qrob_Chr02 2 s_1BFNDA_375 s_1A3VA1_2139 32,5 17 62 lod 3,1 4,2
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nP_A4 Qrob_Chr02 2 s_1A0FUE_1868 s_1A1UAI_500 20,64 20,47 21,36 lod 5.8 10.9
Bourran2_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 24,87 24,63 26,18 lod 3.8 7
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL6_d13Cf Qrob_Chr02 2 s_1AEP21_172 v_6048_204 46.33 22,5 65,23 lod 4.972 0.03
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nSecLBD_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 35,81 34,88 37,45 lod 4.4 10.4
Bourran1_2003_QTL1_peak_Bud_burst_3P Qrob_Chr02 2 s_1AR8KI_1183 s_1B0QB1_473 22 6 41 lod 4,2 11,5
Bourran1_2004_QTL3_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 46 lod 2,9 6,4
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5
Champenoux_2015_nEpis_A4 Qrob_Chr02 2 s_1BAGIZ_823 s_1BN4CB_644 23,06 23,06 23,06 lod 4.9 11
Champenoux_2015_nP_A4 Qrob_Chr02 2 s_1BN4CB_644 v_508_128 23,76 23,06 24,51 lod 2.8 6.2
Champenoux_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 25,35 24,63 26,18 lod 4.0 8.7

0 Targeting